scholarly journals House dust mite allergens Der f and Der p induce IL-31 production by blood-derived T cells from atopic dermatitis patients

2017 ◽  
Vol 27 (4) ◽  
pp. 393-395 ◽  
Author(s):  
Krisztina Szegedi ◽  
Amanda van Lier ◽  
Pieter C. Res ◽  
Saskia Chielie ◽  
Jan D. Bos ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite

scholarly journals Immunohistopathological Analysis of Immunoglobulin E-Positive Epidermal Dendritic Cells with House Dust Mite Antigens in Naturally Occurring Skin Lesions of Adult and Elderly Patients with Atopic Dermatitis

2021 ◽  
Vol 8 (3) ◽  
pp. 426-441
Author(s):  
Ryoji Tanei ◽  
Yasuko Hasegawa
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Atopic Dermatitis ◽  
House Dust ◽  
House Dust Mite ◽  
Immunoglobulin E ◽  
Skin Lesions ◽  
Delayed Type Hypersensitivity ◽  
Dust Mite ◽  
Epidermal Dendritic Cells

The immunopathogenic role of house dust mite (HDM) allergens in the development of skin lesions in atopic dermatitis (AD) has not yet been precisely clarified. We immunohistopathologically evaluated the localization of immunoglobulin E (IgE)-positive epidermal dendritic cells with HDM antigens in the skin lesions of patients with IgE-allergic AD. Using double-immunofluorescence and single-immunochemical staining methods, we analyzed biopsy specimens from the skin lesions of six patients with IgE-allergic AD and HDM allergy and 11 control subjects with inflammatory skin disorders. Inflammatory dendritic epidermal cells (IDECs; CD11c+ and CD206+ cells) were markedly observed in the central area of the spongiotic epidermis of skin lesions in all AD patients. Furthermore, IgE-positive IDECs with HDM antigens in the central areas of the spongiosis were found in four of the six (66.7%) AD patients. Langerhans cells (LCs; CD207+ cells) with HDM antigens were also observed in the peripheral areas of the spongiosis. Infiltration of CD4+ and CD8+ T cells in association with IgE-positive IDECs and LCs with HDM antigens was seen in the spongiotic epidermis. An IgE-mediated delayed-type hypersensitivity reaction, in combination with IgE-bearing dendritic cells, specific T cells, keratinocytes, and HDM antigens, may lead to spongiotic tissue formation in eczematous dermatitis in AD.

Atopic dermatitis, house-dust mite, and the placebo effect

Allergy ◽  
2001 ◽  
Vol 56 (12) ◽  
pp. 1226-1226 ◽  
Author(s):  
C. Gutgesell ◽  
S. Heise ◽  
S. Seubert ◽  
A. Seubert ◽  
S. Domhof ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Placebo Effect ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite

Epicutaneous application of house dust mite induces thymic stromal lymphopoietin in nonlesional skin of patients with atopic dermatitis

2013 ◽  
Vol 132 (5) ◽  
pp. 1252-1254 ◽  
Author(s):  
Janneke Landheer ◽  
Barbara Giovannone ◽  
Jeanine D. Mattson ◽  
Sandra Tjabringa ◽  
Carla A.F.M. Bruijnzeel-Koomen ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
House Dust ◽  
House Dust Mite ◽  
Thymic Stromal Lymphopoietin ◽  
Dust Mite

Effect of House Dust Mite (HDM) Avoidance Measure on The Clinical Symptoms in Dogs with Atopic Dermatitis (AD)

2007 ◽  
Vol 119 (1) ◽  
pp. S281
Author(s):  
S. Kawarai ◽  
H. Shirai ◽  
M. Sakaguchi ◽  
K. Ohmori ◽  
N. Yasuda ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
House Dust ◽  
House Dust Mite ◽  
Clinical Symptoms ◽  
Dust Mite

scholarly journals The Role of Radioallergosorbent Testing (RAST) Early in the Management of Atopic Dermatitis in Children and Adults Referred to Secondary Care in the United Kingdom

2019 ◽  
Vol 4 (2) ◽  
Keyword(s):  
Atopic Dermatitis ◽  
House Dust ◽  
House Dust Mite ◽  
Secondary Care ◽  
High Serum ◽  
Cow’S Milk ◽  
Clinical Test ◽  
Cow's Milk ◽  
The United Kingdom ◽  
Dust Mite

Aim: To evaluate the importance and relevance of doing radioallegrosorbent testing (RAST) for patients referred with atopic dermatitis (AD) to secondary care for specialist dermatological advice and investigation. Background: Atopic dermatitis is usually diagnosed by Primary Care General Practitioners and treated using a stepped approach. Referral to secondary care is considered when it is not controlled with optimal treatment or if an allergy is suspected. Radioallegrosorbent testing is useful for identifying trigger factors however current literature lacks evidence for the extent to which RAST testing can improve patient symptoms. Method: Standard RAST testing was requested for all patients referred to secondary care with atopic dermatitis. Allergens tested included: dairy products, house dust mite, grass, nuts, seafood, cereals, dog dander and cat epithelium. Results: RAST results showed that 92.3% of children and 60.7% of adults had high total lgE levels. The proportion of children with high serum specific lgE for the allergens tested were as follows: house dust mite (60.4%), grass (50%), dairy/cow’s milk (39.5%), nuts (29.1%), dog dander (16.6%), cat epithelium (12.5%), egg (10.4%), fish/seafood (6.2%), wheat (6.2%), and soya (2.0%). The results for the adults tested were as follows: house dust mite (64.7%), grass (58.8%), cat epithelium (29%), dog dander (23%), nuts (11.7%), egg (11.7%), cow’s milk/dairy (5.8%), wheat/ soya (0%). On follow-up, all patients reported an improvement in their AD after implementing allergen avoidance strategies. Conclusions: RAST testing is a valuable clinical test that should be considered early to investigate patients with AD for relevant allergens that may be exacerbating their symptoms and causing resistance to first line treatment.

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