Dual oxidase 2 is essential for house dust mite-induced pro-inflammatory cytokine production in human keratinocytes

2015 ◽  
Vol 24 (12) ◽  
pp. 936-941 ◽  
Author(s):  
Eunbi Ko ◽  
Hyun Choi ◽  
Kkot-Nara Park ◽  
Ju-Yearl Park ◽  
Tae Ryong Lee ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Human Keratinocytes ◽  
Inflammatory Cytokine Production ◽  
Dual Oxidase ◽  
Dust Mite

scholarly journals IL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite–induced asthma models

2017 ◽  
Vol 214 (10) ◽  
pp. 3037-3050 ◽  
Author(s):  
Takashi Ito ◽  
Koichi Hirose ◽  
Aiko Saku ◽  
Kenta Kono ◽  
Hiroaki Takatori ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Cytokine Production ◽  
Allergic Airway Inflammation ◽  
Lung Epithelial Cells ◽  
Intratracheal Administration ◽  
Lung Epithelial ◽  
Dust Mite

Previous studies have shown that IL-22, one of the Th17 cell–related cytokines, plays multiple roles in regulating allergic airway inflammation caused by antigen-specific Th2 cells; however, the underlying mechanism remains unclear. Here, we show that allergic airway inflammation and Th2 and Th17 cytokine production upon intratracheal administration of house dust mite (HDM) extract, a representative allergen, were exacerbated in IL-22-deficient mice. We also found that IL-22 induces Reg3γ production from lung epithelial cells through STAT3 activation and that neutralization of Reg3γ significantly exacerbates HDM-induced eosinophilic airway inflammation and Th2 cytokine induction. Moreover, exostatin-like 3 (EXTL3), a functional Reg3γ binding protein, is expressed in lung epithelial cells, and intratracheal administration of recombinant Reg3γ suppresses HDM-induced thymic stromal lymphopoietin and IL-33 expression and accumulation of type 2 innate lymphoid cells in the lung. Collectively, these results suggest that IL-22 induces Reg3γ production from lung epithelial cells and inhibits the development of HDM-induced allergic airway inflammation, possibly by inhibiting cytokine production from lung epithelial cells.

scholarly journals Inhaled house dust mite induces pulmonary T helper 2 cytokine production

2009 ◽  
Vol 39 (10) ◽  
pp. 1597-1610 ◽  
Author(s):  
L. G. Gregory ◽  
B. Causton ◽  
J. R. Murdoch ◽  
S. A. Mathie ◽  
V. O'Donnell ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Cytokine Production ◽  
T Helper ◽  
T Helper 2 ◽  
Dust Mite
Sign in / Sign up

Export Citation Format

Share Document