Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice

2015 ◽  
Vol 24 (6) ◽  
pp. 418-423 ◽  
Author(s):  
Vengadeshprabhu Karuppagounder ◽  
Somasundaram Arumugam ◽  
Rajarajan A. Thandavarayan ◽  
Vigneshwaran Pitchaimani ◽  
Remya Sreedhar ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Transgenic Mice ◽  
Quercetin Treatment

scholarly journals Anti-inflammatory effects of Capparis ecuadorica extract in phthalic-anhydride-induced atopic dermatitis of IL-4/Luc/CNS-1 transgenic mice

2020 ◽  
Vol 58 (1) ◽  
pp. 1263-1276
Author(s):  
Bo Ram Song ◽  
Su Jin Lee ◽  
Ji Eun Kim ◽  
Hyeon Jun Choi ◽  
Su Ji Bae ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Transgenic Mice ◽  
Phthalic Anhydride ◽  
Anti Inflammatory

Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice

2016 ◽  
Vol 7 (2) ◽  
pp. 215-225 ◽  
Author(s):  
R. Mariman ◽  
E. Reefman ◽  
F. Tielen ◽  
C. Persoon-Deen ◽  
K. van de Mark ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mast Cells ◽  
Transgenic Mice ◽  
Lactobacillus Plantarum ◽  
Oral Treatment ◽  
Skin Barrier ◽  
Interferon Γ ◽  
Skin Barrier Function ◽  
Cytokine Analysis ◽  
Major Factors

Genetic predisposition and environmental factors, including the gut microbiota, have been suggested as major factors in the development and progression of atopic dermatitis. Hyperlipidemic human APOC1+/+ transgenic mice display many features of human atopic dermatitis, such as scaling, lichenification, excoriations, and pruritus, along with a disturbed skin barrier function. Cytokine analysis of serum shows an increase of various pro-inflammatory cytokines, including interleukin (IL)-12p40, IL-6, and IL-1α, but lower levels of interferon-γ. These mice also display aspects of colitis evident from macroscopic and histological abnormalities. Genome-wide transcriptome analysis of the intestine shows up-regulation of several genes associated with mast cells and eosinophils and this observation was confirmed by demonstrating increased numbers of IgE+ and FcRε+ mast cells in the colon and in the skin. Oral treatment with Lactobacillus plantarum NCIMB8826 resulted in decreased numbers of mast cells in the colon. Moreover, this L. plantarum strain ameliorated skin pathology, evident from improved skin barrier integrity, absence of skin thickening, and less excoriations. These results suggest that modulation of intestinal immune homeostasis contributes to the suppression of atopic dermatitis.

scholarly journals Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin

2005 ◽  
Vol 202 (4) ◽  
pp. 541-549 ◽  
Author(s):  
Jane Yoo ◽  
Miyuki Omori ◽  
Dora Gyarmati ◽  
Baohua Zhou ◽  
Theingi Aye ◽  
...  
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Transgenic Mice ◽  
Elevated Serum ◽  
Allergic Inflammation ◽  
Disease Process ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Thymic Stromal Lymphopoietin ◽  
Common Disease

The cytokine thymic stromal lymphopoietin (TSLP) has recently been implicated in the pathogenesis of atopic dermatitis (AD) and other allergic diseases in humans. To further characterize its role in this disease process, transgenic mice were generated that express a keratinocyte-specific, tetracycline-inducible TSLP transgene. Skin-specific overexpression of TSLP resulted in an AD-like phenotype, with the development of eczematous lesions containing inflammatory dermal cellular infiltrates, a dramatic increase in Th2 CD4+ T cells expressing cutaneous homing receptors, and elevated serum levels of IgE. These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease.

Dysregulated microRNA expression in IL-4 transgenic mice, an animal model of atopic dermatitis

2021 ◽  
Author(s):  
Lei Bao ◽  
Cecilia S. Chau ◽  
Zhengdeng Lei ◽  
Hong Hu ◽  
Angelina G. Chan ◽  
...  
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Transgenic Mice ◽  
Microrna Expression
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