scholarly journals Resveratrol induces autophagy through death-associated protein kinase 1 (DAPK1) in human dermal fibroblasts under normal culture conditions

2013 ◽  
Vol 22 (7) ◽  
pp. 491-494 ◽  
Author(s):  
Min Sik Choi ◽  
Yoonkyung Kim ◽  
Ji-Yong Jung ◽  
Seung Ha Yang ◽  
Tae Ryong Lee ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Culture Conditions ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Normal Culture ◽  
Death Associated Protein Kinase

scholarly journals Piper retrofractumVahl. Extract, as a PPARδand AMPK Activator, Suppresses UVB-Induced Photoaging through Mitochondrial Biogenesis and MMPs Inhibition in Human Dermal Fibroblasts and Hairless Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Jungon Yun ◽  
Changhee Kim ◽  
Mi-Bo Kim ◽  
Jae-Kwan Hwang
Keyword(s):  
Protein Kinase ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Mouse Skin ◽  
Adenosine Monophosphate ◽  
Dermal Fibroblasts ◽  
Mitogen Activated Protein Kinase ◽  
Peroxisome Proliferator ◽  
Human Dermal Fibroblasts ◽  
Piper Retrofractum

Photoaging occurs by UVB-irradiation and involves production of reactive oxygen species (ROS) and overexpression of matrix metalloproteinases (MMPs), leading to extracellular matrix damage.Piper retrofractumVahl. is used as a traditional medicine for antiflatulence, expectorant, sedative, and anti-irritant; however, its antiphotoaging effect has not yet been studied. The current study investigated the antiphotoaging effect of standardizedPiper retrofractumextract (PRE) on UVB-damaged human dermal fibroblasts and hairless mouse skin. PRE treatment activated the peroxisome proliferator-activated receptor delta (PPARδ) and the adenosine monophosphate-activated protein kinase (AMPK), consequently upregulating mitochondrial synthesis and reducing ROS production. Additionally, PRE inhibited MMPs expression via suppressing mitogen-activated protein kinase (MAPK) and activator protein-1 (AP-1). PRE downregulated UVB-induced inflammatory reactions by inhibiting the nuclear factor-kappa B (NF-κB) activity. PRE also enhanced transforming growth factor-beta (TGF-β) and the Smad signaling pathway, thereby promoting procollagen gene transcription. Furthermore, oral administration of PRE (300 mg/kg/day) similarly regulated the signaling pathways and increased antioxidant enzyme expression, thus attenuating physiological deformations, such as wrinkle formation and erythema response. Collectively, these results suggest that PRE acts as a potent antiphotoaging agent via PPARδand AMPK activation.

scholarly journals The c-Abl tyrosine kinase controls protein kinase Cδ-induced Fli-1 phosphorylation in human dermal fibroblasts

2011 ◽  
Vol 63 (6) ◽  
pp. 1729-1737 ◽  
Author(s):  
Andreea M. Bujor ◽  
Yoshihide Asano ◽  
Paul Haines ◽  
Robert Lafyatis ◽  
Maria Trojanowska
Keyword(s):  
Protein Kinase ◽  
Tyrosine Kinase ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Abl Tyrosine Kinase ◽  
Protein Kinase Cδ

Protein kinase C-α levels are inversely associated with growth rate in cultured human dermal fibroblasts

1998 ◽  
Vol 18 (1) ◽  
pp. 54-63 ◽  
Author(s):  
Sung Woo Choi ◽  
Hee-Young Park ◽  
Nelly G. Rubeiz ◽  
Dana Sachs ◽  
Barbara A. Gilchrest
Keyword(s):  
Growth Rate ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Kinase C
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