scholarly journals NADPH oxidase is a novel target of delphinidin for the inhibition of UVB-induced MMP-1 expression in human dermal fibroblasts

2013 ◽  
Vol 22 (6) ◽  
pp. 428-430 ◽  
Author(s):  
Tae-Gyu Lim ◽  
Sung Keun Jung ◽  
Jong-eun Kim ◽  
Yoona Kim ◽  
Hyong Joo Lee ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Novel Target

NADPH oxidase-2 is a key regulator of human dermal fibroblasts: a potential therapeutic strategy for the treatment of skin fibrosis

2014 ◽  
Vol 23 (9) ◽  
pp. 639-644 ◽  
Author(s):  
Guo-You Zhang ◽  
Liang-Cai Wu ◽  
Tao Dai ◽  
Shi-Yi Chen ◽  
An-Yuan Wang ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Therapeutic Strategy ◽  
Dermal Fibroblasts ◽  
Skin Fibrosis ◽  
Human Dermal Fibroblasts ◽  
Nadph Oxidase 2

scholarly journals Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Eun-Mi Noh ◽  
Jinny Park ◽  
Hwa-Ryung Song ◽  
Jeong-Mi Kim ◽  
Minok Lee ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Signaling Pathway ◽  
Skin Aging ◽  
Dermal Fibroblasts ◽  
Ros Generation ◽  
Human Dermal Fibroblasts ◽  
Chronological Aging ◽  
Aged Skin ◽  
Pi3k Signaling Pathway ◽  
High Level

Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin aging through their damaging effect on cellular constituents. However, the origins of ROS have not been fully elucidated. We investigated that ROS generation of replicative senescent fibroblasts is generated by the modulation of phosphatidylinositol 3,4,5-triphosphate (PIP3) metabolism. Reduction of the PTEN protein, which dephosphorylates PIP3, was responsible for maintaining a high level of PIP3 in replicative cells and consequently mediated the activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway. Increased ROS production was blocked by inhibition of PI3K or protein kinase C (PKC) or by NADPH oxidase activating in replicative senescent cells. These data indicate that the signal pathway to ROS generation in replicative aged skin cells can be stimulated by reduced PTEN level. Our results provide new insights into skin aging-associated modification of the PI3K/NADPH oxidase signaling pathway and its relationship with a skin aging-dependent increase of ROS in human dermal fibroblasts.

Very long chain fatty acids activate NADPH oxidase in human dermal fibroblasts

2004 ◽  
Vol 23 (1) ◽  
pp. 65-68 ◽  
Author(s):  
Gursev S. Dhaunsi ◽  
Jaspal Kaur ◽  
Khaled Alsaeid ◽  
Ronald B. Turner ◽  
Milad S. Bitar
Keyword(s):  
Fatty Acids ◽  
Nadph Oxidase ◽  
Dermal Fibroblasts ◽  
Long Chain Fatty Acids ◽  
Human Dermal Fibroblasts ◽  
Long Chain ◽  
Chain Fatty Acids

scholarly journals Non pharmacological high-intensity ultrasound treatment of human dermal fibroblasts to accelerate wound healing

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jeong Yu Lee ◽  
Dae-Jin Min ◽  
Wanil Kim ◽  
Bum-Ho Bin ◽  
Kyuhan Kim ◽  
...  
Keyword(s):  
Wound Healing ◽  
High Intensity ◽  
Mapk Pathway ◽  
Dermal Fibroblasts ◽  
Ultrasound Treatment ◽  
Type I ◽  
Human Dermal Fibroblasts ◽  
Short Term ◽  
High Intensity Ultrasound ◽  
Extracellular Matrix Components

AbstractInspired by the effectiveness of low-intensity ultrasound on tissue regeneration, we investigated the potential effect of short-term high-intensity ultrasound treatment for acceleration of wound healing in an in vitro wound model and dermal equivalent, both comprising human dermal fibroblasts. Short-term ultrasound of various amplitudes significantly increased the proliferation and migration of fibroblasts and subsequently increased the production of the extracellular matrix components fibronectin and collagen type I, both of which are important for wound healing and are secreted by fibroblasts. In addition, ultrasound treatment increased the contraction of a fibroblast-embedded three-dimensional collagen matrix, and the effect was synergistically increased in the presence of TGF-β. RNA-sequencing and bioinformatics analyses revealed changes in gene expression and p38 and ERK1/2 MAPK pathway activation in the ultrasound-stimulated fibroblasts. Our findings suggest that ultrasound as a mechanical stimulus can activate human dermal fibroblasts. Therefore, the activation of fibroblasts using ultrasound may improve the healing of various types of wounds and increase skin regeneration.

Deciphering the role of cartilage protein 1 in human dermal fibroblasts: a transcriptomic approach

2021 ◽  
Author(s):  
Sophia Letsiou ◽  
Manuel Manchado ◽  
Mariela Zografaki ◽  
Sofia Marka ◽  
Liliana Anjos ◽  
...  
Keyword(s):  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts
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