Pituitary tumor-transforming gene 1 as a proliferation marker lacking prognostic value in cutaneous squamous cell carcinoma

2013 ◽  
Vol 22 (5) ◽  
pp. 318-322 ◽  
Author(s):  
Yosuke Ishitsuka ◽  
Yasuhiro Kawachi ◽  
Shijima Taguchi ◽  
Hiroshi Maruyama ◽  
Yoshiyuki Nakamura ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pituitary Tumor ◽  
Prognostic Value ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Proliferation Marker ◽  
Pituitary Tumor Transforming Gene ◽  
Transforming Gene

scholarly journals Alteration of Pituitary Tumor Transforming Gene 1 by MicroRNA-186 and 655 Regulates Invasion Ability of Human Oral Squamous Cell Carcinoma

2021 ◽  
Vol 22 (3) ◽  
pp. 1021
Author(s):  
Sang Shin Lee ◽  
Jong Ho Choi ◽  
Seung Mook Lim ◽  
Gi Jin Kim ◽  
Suk Keun Lee ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Pituitary Tumor ◽  
Western Blots ◽  
Pituitary Tumor Transforming Gene ◽  
And Function ◽  
Transforming Gene ◽  
New Strategies

Background: Pituitary tumor-transforming gene 1 (PTTG1) was recently shown to be involved in the progression as well as the metastasis of cancers. However, their expression and function in the invasion of oral squamous cell carcinoma (SCC) remain unclear. Methods: The expressions of PTTG1 and PTTG1-targeted miRNA in oral SCC cell lines and their invasion capability depended on PTTG1 expression were analyzed by quantitative RT-PCR, Western blots, the transwell insert system and Zymography. Results: Invasion abilities were decreased in oral SCC cells treated with siRNA-PTTG1. When PTTG1 were downregulated in oral SCC cells treated with microRNA-186 and -655 inhibited their invasion abilities via MMP-9 activity. Conclusions: These results indicate that alteration of expression of PTTG1 in oral SCC cells by newly identified microRNA-186 and -655 can regulate invasion activity. Therefore, these data offer new insights into further understanding PTTG1 function in oral SCC and should provide new strategies for diagnostic markers for oral SCC.

scholarly journals 121 Prognostic value of INPP5A expression in recurrent and metastatic cutaneous squamous cell carcinoma

2019 ◽  
Vol 139 (5) ◽  
pp. S21
Author(s):  
C.J. Maly ◽  
H. Cumsky ◽  
C. Costello ◽  
J. Montoya ◽  
J. Schmidt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Cutaneous Squamous Cell Carcinoma
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