scholarly journals Macroevolutionary Foundations of a Recently‐Evolved Innate Immune Defense

Evolution ◽  
2021 ◽  
Author(s):  
Milan Vrtílek ◽  
Daniel I. Bolnick
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense

The roles of grouper TANK in innate immune defense against iridovirus and nodavirus infections

2020 ◽  
Vol 104 ◽  
pp. 506-516
Author(s):  
Jingguang Wei ◽  
Chen Li ◽  
Jisheng Ou ◽  
Xin Zhang ◽  
Zetian Liu ◽  
...  
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense

Black carp STING functions importantly in innate immune defense against RNA virus

2017 ◽  
Vol 70 ◽  
pp. 13-24 ◽  
Author(s):  
Liang Lu ◽  
Xu Wang ◽  
Sizhong Wu ◽  
Xuejiao Song ◽  
Ziqi Zou ◽  
...  
Keyword(s):  
Rna Virus ◽  
Immune Defense ◽  
Innate Immune ◽  
Black Carp ◽  
Innate Immune Defense

scholarly journals Innate immune defense in the inner ear - mucines are expressed by the human endolymphatic sac

2016 ◽  
Vol 230 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Martin N. Møller ◽  
Svend Kirkeby ◽  
Per Cayé-Thomasen
Keyword(s):  
Inner Ear ◽  
Immune Defense ◽  
Innate Immune ◽  
Endolymphatic Sac ◽  
Innate Immune Defense

scholarly journals Metabolic acidosis stimulates the production of the antimicrobial peptide cathelicidin in rabbit urine

2017 ◽  
Vol 313 (5) ◽  
pp. F1061-F1067 ◽  
Author(s):  
Hu Peng ◽  
Jeffrey M. Purkerson ◽  
Andy L. Schwaderer ◽  
George J. Schwartz
Keyword(s):  
Antimicrobial Activity ◽  
Metabolic Acidosis ◽  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Immune Defense ◽  
Innate Immune ◽  
E Coli ◽  
Innate Immune Defense ◽  
Normal Urine ◽  
Tract Infections

Intercalated cells of the collecting duct (CD) are critical for acid-base homeostasis and innate immune defense of the kidney. Little is known about the impact of acidosis on innate immune defense in the distal nephron. Urinary tract infections are mainly due to Escherichia coli and are an important risk factor for development of chronic kidney disease. While the effect of urinary pH on growth of E. coli is well established, in this study, we demonstrate that acidosis increases urine antimicrobial activity due, at least in part, to induction of cathelicidin expression within the CD. Acidosis was induced in rabbits by adding NH4Cl to the drinking water and reducing food intake over 3 days or by casein supplementation. Microdissected CDs were examined for cathelicidin mRNA expression and antimicrobial activity, and cathelicidin protein levels in rabbit urine were measured. Cathelicidin expression in CD cells was detected in kidney sections. CDs from acidotic rabbits expressed three times more cathelicidin mRNA than those isolated from normal rabbits. Urine from acidotic rabbits had significantly more antimicrobial activity (vs. E. coli) than normal urine, and most of this increased activity was blocked by cathelicidin antibody. The antibody had little effect on antimicrobial activity of normal urine. Urine from acidotic rabbits had at least twice the amount of cathelicidin protein as did normal urine. We conclude that metabolic acidosis not only stimulates CD acid secretion but also induces expression of cathelicidin and, thereby, enhances innate immune defense against urinary tract infections via induction of antimicrobial peptide expression.

scholarly journals Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity

2015 ◽  
pp. 1-10 ◽  
Author(s):  
Danielle J. Botelho ◽  
Bey Fen Leo ◽  
Christopher B. Massa ◽  
Srijata Sarkar ◽  
Terry D. Tetley ◽  
...  
Keyword(s):  
Low Dose ◽  
Immune Defense ◽  
Innate Immune ◽  
Mechanical Function ◽  
Cellular Toxicity ◽  
Innate Immune Defense

Collectin-mediated innate immune defense in the lung

2006 ◽  
Vol 2 (4) ◽  
pp. 230-236
Author(s):  
Henk P. Haagsman ◽  
Astrid Hogenkamp ◽  
Martin Van Eijk
Keyword(s):  
Immune Defense ◽  
Innate Immune ◽  
Innate Immune Defense

2P-0395 Surfactant protein D of the innate immune defense is negatively associated with obesity

2003 ◽  
Vol 4 (2) ◽  
pp. 125
Author(s):  
U. Holmskov ◽  
G. Lyster ◽  
J. Hjelmborg ◽  
R. Leth-Larsen ◽  
V. Moeller ◽  
...  
Keyword(s):  
Surfactant Protein ◽  
Immune Defense ◽  
Innate Immune ◽  
Surfactant Protein D ◽  
Negatively Associated ◽  
Innate Immune Defense
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