scholarly journals Cytogenomic analysis unveils mixed molecular evolution and recurrent chromosome rearrangements shaping the multigene families on Schistocerca grasshopper genomes

Evolution ◽  
2021 ◽  
Author(s):  
Emiliano Martí ◽  
Diogo Milani ◽  
Vanessa B. Bardella ◽  
Lucas Albuquerque ◽  
Hojun Song ◽  
...  
Keyword(s):  
Molecular Evolution ◽  
Chromosome Rearrangements ◽  
Multigene Families

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

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