scholarly journals Imposed mutational meltdown as an antiviral strategy

Evolution ◽  
2020 ◽  
Vol 74 (12) ◽  
pp. 2549-2559 ◽  
Author(s):  
Jeffrey D. Jensen ◽  
Ryan A. Stikeleather ◽  
Timothy F. Kowalik ◽  
Michael Lynch
Keyword(s):  
Mutational Meltdown

scholarly journals Genetic Load and Potential Mutational Meltdown in Cancer Cell Populations

2019 ◽  
Vol 36 (3) ◽  
pp. 541-552 ◽  
Author(s):  
Yuezheng Zhang ◽  
Yawei Li ◽  
Tao Li ◽  
Xu Shen ◽  
Tianqi Zhu ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Genetic Load ◽  
Cell Populations ◽  
Mutational Meltdown

MUTATIONAL MELTDOWN IN SELFINGARABIDOPSIS LYRATA

Evolution ◽  
2012 ◽  
Vol 67 (3) ◽  
pp. 806-815 ◽  
Author(s):  
Yvonne Willi
Keyword(s):  
Mutational Meltdown

scholarly journals Species Formation in Simple Ecosystems

1998 ◽  
Vol 09 (04) ◽  
pp. 555-571 ◽  
Author(s):  
F. Bagnoli ◽  
M. Bezzi
Keyword(s):  
Cellular Automaton ◽  
Long Range ◽  
Mutation Rate ◽  
Total Population ◽  
Fitness Function ◽  
Analytical Approximation ◽  
The Other ◽  
Collective Behaviors ◽  
Species Formation ◽  
Mutational Meltdown

In this paper we consider a microscopic model of a simple ecosystem. The basic ingredients of this model are individuals, and both the phenotypic and genotypic levels are taken in account. The model is based on a long range cellular automaton (CA); introducing simple interactions between the individuals, we get some of the complex collective behaviors observed in a real ecosystem. Since our fitness function is smooth, the model does not exhibit the error threshold transition; on the other hand the size of total population is not kept constant, and the mutational meltdown transition is present. We study the effects of competition between genetically similar individuals and how it can lead to species formation. This speciation transition does not depend on the mutation rate. We present also an analytical approximation of the model.

scholarly journals Two sides of the same coin: A population genetics perspective on lethal mutagenesis and mutational meltdown

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Sebastian Matuszewski ◽  
Louise Ormond ◽  
Claudia Bank ◽  
Jeffrey D. Jensen
Keyword(s):  
Population Genetics ◽  
Lethal Mutagenesis ◽  
Two Sides ◽  
Mutational Meltdown

Sidestepping Mutational Meltdown

Science ◽  
2008 ◽  
Vol 319 (5865) ◽  
pp. 914-915 ◽  
Author(s):  
Eric A. Shoubridge ◽  
Timothy Wai
Keyword(s):  
Mutational Meltdown

Mitochondria—Striking a balance between host and endosymbiont

Science ◽  
2019 ◽  
Vol 365 (6454) ◽  
pp. eaaw9855 ◽  
Author(s):  
Richard J. Youle
Keyword(s):  
Gene Expression ◽  
Quality Control ◽  
Energy Production ◽  
Viral Infections ◽  
Nuclear Genome ◽  
Innate Immune ◽  
Mitochondrial Genomes ◽  
Proteotoxic Stress ◽  
Immune Pathways ◽  
Mutational Meltdown

Mitochondria are organelles with their own genome that arose from α-proteobacteria living within single-celled Archaea more than a billion years ago. This step of endosymbiosis offered tremendous opportunities for energy production and metabolism and allowed the evolution of fungi, plants, and animals. However, less appreciated are the downsides of this endosymbiosis. Coordinating gene expression between the mitochondrial genomes and the nuclear genome is imprecise and can lead to proteotoxic stress. The clonal reproduction of mitochondrial DNA requires workarounds to avoid mutational meltdown. In metazoans that developed innate immune pathways to thwart bacterial and viral infections, mitochondrial components can cross-react with pathogen sensors and invoke inflammation. Here, I focus on the numerous and elegant quality control processes that compensate for or mitigate these challenges of endosymbiosis.

scholarly journals Mutational Meltdown in Primary Endosymbionts: Selection Limits Muller's Ratchet

PLoS ONE ◽  
2009 ◽  
Vol 4 (3) ◽  
pp. e4969 ◽  
Author(s):  
Julie M. Allen ◽  
Jessica E. Light ◽  
M. Alejandra Perotti ◽  
Henk R. Braig ◽  
David L. Reed
Keyword(s):  
Muller's Ratchet ◽  
Muller’S Ratchet ◽  
Mutational Meltdown

Synergism between mutational meltdown and Red Queen in parthenogenetic biotypes of the freshwater planarianSchmidtea polychroa

Oikos ◽  
2007 ◽  
Vol 116 (2) ◽  
pp. 313-323 ◽  
Author(s):  
Ruža Bruvo ◽  
Hinrich Schulenburg ◽  
Martin Storhas ◽  
Nico K. Michiels
Keyword(s):  
Red Queen ◽  
Mutational Meltdown
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