scholarly journals Disease swamps molecular signatures of genetic‐environmental associations to abiotic factors in Tasmanian devil ( Sarcophilus harrisii ) populations

Evolution ◽  
2020 ◽  
Vol 74 (7) ◽  
pp. 1392-1408 ◽  
Author(s):  
Alexandra K. Fraik ◽  
Mark J. Margres ◽  
Brendan Epstein ◽  
Soraia Barbosa ◽  
Menna Jones ◽  
...  
Keyword(s):  
Abiotic Factors ◽  
Tasmanian Devil ◽  
Molecular Signatures ◽  
Sarcophilus Harrisii

scholarly journals Disease swamps molecular signatures of genetic-environmental associations to abiotic factors in Tasmanian devil (Sarcophilus harrisii) populations

2019 ◽  
Author(s):  
Alexandra K. Fraik ◽  
Mark J. Margres ◽  
Brendan Epstein ◽  
Soraia Barbosa ◽  
Menna Jones ◽  
...  
Keyword(s):  
Spatial Variation ◽  
Local Adaptation ◽  
Environmental Variables ◽  
Abiotic Factors ◽  
Rapid Onset ◽  
Tasmanian Devil ◽  
Landscape Genomics ◽  
Abiotic Environment ◽  
Candidate Loci ◽  
Sarcophilus Harrisii

AbstractLandscape genomics studies focus on identifying candidate genes under selection via spatial variation in abiotic environmental variables, but rarely by biotic factors such as disease. The Tasmanian devil (Sarcophilus harrisii) is found only on the environmentally heterogeneous island of Tasmania and is threatened with extinction by a nearly 100% fatal, transmissible cancer, devil facial tumor disease (DFTD). Devils persist in regions of long-term infection despite epidemiological model predictions of species’ extinction, suggesting possible adaptation to DFTD. Here, we test the extent to which spatial variation and genetic diversity are associated with the abiotic environment and/or by DFTD. We employ genetic-environment association (GEAs) analyses using a RAD-capture panel consisting of 6,886 SNPs from 3,286 individuals sampled pre- and post-disease arrival. Pre-disease, we find significant correlations of allele frequencies with environmental variables, including 349 unique loci linked to 64 genes, suggesting local adaptation to abiotic environment. Following DFTD arrival, however, we detected few of the pre-disease candidate loci, but instead frequencies of candidate loci linked to 14 genes correlated with disease prevalence. Loss of apparent signal of abiotic local adaptation following disease arrival suggests swamping by the strong selection imposed by DFTD. Further support for this result comes from the fact that post-disease candidate loci are in linkage disequilibrium with genes putatively involved in immune response, tumor suppression and apoptosis. This suggests the strength GEA associations of loci with the abiotic environment are swamped resulting from the rapid onset of a biotic selective pressure.

Inguinal panniculitis in a young Tasmanian devil (Sarcophilus harrisii) caused byMycobacterium mageritense

2010 ◽  
Vol 88 (5) ◽  
pp. 197-200 ◽  
Author(s):  
G Reppas ◽  
P Nosworthy ◽  
T Hansen ◽  
M Govendir ◽  
R Malik
Keyword(s):  
Tasmanian Devil ◽  
Sarcophilus Harrisii

scholarly journals Curse of the devil: molecular insights into the emergence of transmissible cancers in the Tasmanian devil (Sarcophilus harrisii)

2020 ◽  
Vol 77 (13) ◽  
pp. 2507-2525 ◽  
Author(s):  
Amanda L. Patchett ◽  
Andrew S. Flies ◽  
A. Bruce Lyons ◽  
Gregory M. Woods
Keyword(s):  
Tasmanian Devil ◽  
The Devil ◽  
Sarcophilus Harrisii

Doxorubicin and carboplatin trials in Tasmanian devils (Sarcophilus harrisii) with Tasmanian devil facial tumor disease

2015 ◽  
Vol 206 (3) ◽  
pp. 312-316 ◽  
Author(s):  
David N. Phalen ◽  
Angela E. Frimberger ◽  
Sarah Peck ◽  
Stephen Pyecroft ◽  
Colette Harmsen ◽  
...  
Keyword(s):  
Tasmanian Devil ◽  
Devil Facial Tumor Disease ◽  
Sarcophilus Harrisii

scholarly journals Relict or reintroduction? Genetic population assignment of three Tasmanian devils ( Sarcophilus harrisii ) recovered on mainland Australia

2017 ◽  
Vol 4 (4) ◽  
pp. 170053 ◽  
Author(s):  
Lauren C. White ◽  
Jeremy J. Austin
Keyword(s):  
Tasmanian Devil ◽  
Nucleotide Polymorphisms ◽  
Genetic Population ◽  
Single Nucleotide ◽  
Mainland Population ◽  
Devil Facial Tumour Disease ◽  
Eastern Australia ◽  
The Devil ◽  
Disease Free ◽  
Sarcophilus Harrisii

Today, the Tasmanian devil ( Sarcophilus harrisii ) is found only on the island of Tasmania, despite once being widespread across mainland Australia. While the devil is thought to have become extinct on the mainland approximately 3000 years ago, three specimens were collected in Victoria (south-eastern Australia) between 1912 and 1991, raising the possibility that a relict mainland population survived in the area. Alternatively, these devils may have escaped captivity or were deliberately released after being transported from Tasmania, a practice that has been strictly controlled since the onset of devil facial tumour disease in the early 1990s. Such quarantine regimes are important to protect disease-free, ‘insurance populations’ in zoos on the mainland. To test whether the three Victorian devils were members of a relict mainland population or had been recently transported from Tasmania we identified seven single nucleotide polymorphisms (SNPs) in the mitochondrial genome that can distinguish between Tasmanian and ancient mainland populations. The three Victorian devil specimens have the same seven SNPs diagnostic of modern Tasmanian devils, confirming that they were most likely transported from Tasmania and do not represent a remnant population of mainland devils.

Retinal projections in the tasmanian devil,Sarcophilus harrisii

1979 ◽  
Vol 188 (2) ◽  
pp. 335-345 ◽  
Author(s):  
K. J. Sanderson ◽  
L. J. Pearson ◽  
J. R. Haight
Keyword(s):  
Tasmanian Devil ◽  
Retinal Projections ◽  
Sarcophilus Harrisii

A Comparison of Tooth Microwear Between an Extinct Marsupial Predator, the Tasmanian Tiger Thylacinus-Cynocephalus (Thylacinidae) and an Extant Scavenger, the Tasmanian Devil Sarcophilus-Harrisii (Dasyuridae, Marsupialia)

1989 ◽  
Vol 37 (5) ◽  
pp. 575 ◽  
Author(s):  
SK Robson ◽  
WG Young
Keyword(s):  
Species Differences ◽  
Intraspecific Variability ◽  
Leading Edge ◽  
Interspecific Variation ◽  
Tasmanian Devil ◽  
Trailing Edge ◽  
Carnivorous Species ◽  
High Degree ◽  
Number Of Individuals ◽  
Sarcophilus Harrisii

Tooth microwear patterns in the predator Thylacinus cynocephalus and the scavenger Sarcophilus harrisii were examined as potentical indicators of dietary differences and occlusal mechanics. Homologous proximal facets on the metacrista of the maxillary right 3rd molar of each species were examined as gold coated replicas under the SEM. The density, dimensions and relative abundances of microwear features were recorded. Significant intrafacet microwear variation exists relative to the direction of the occlusal stroke in Thylacinus. Striation and pit frequency are inversely correlated down the facet, with striations being more frequent at the leading edge; pits are larger and more frequent at the trailing edge. This pattern supports proposed models of the carnassial chewing stroke, where it is predicted that the shearing component, that produces striations, is greater at the leading edge of the facet, while the compression component of the occlusal stroke, which results in relatively more pits, is greater at the trailing edge of the facet. Significant intraspecific and interspecific variation is found in microwear feature dimensions, and densities. Pit diameters and densities are significantly greater in Thylacinus, although only approximately 11% of the total variance in these features was attributable to species differences. The remaining variance was distributed equally between individuals of the same species, and the leading and trailing regions of the facet. The high degree of intraspecific variability indicates that in carnivorous species at least, a sufficient number of individuals must be examined before accurate dietary interpretations and comparisons with other species can be made.

Rates of Water Turnover in Marsupials and Eutherians: a Comparative Review With New Data on the Tasmanian Devil.

1978 ◽  
Vol 26 (3) ◽  
pp. 465 ◽  
Author(s):  
SC Nicol
Keyword(s):  
Statistical Analysis ◽  
Turnover Rate ◽  
Tritiated Water ◽  
Tasmanian Devil ◽  
Turnover Rates ◽  
Water Turnover ◽  
Comparative Review ◽  
Lactating Females ◽  
Total Body ◽  
Sarcophilus Harrisii

Water turnover rates of Tasmania devils, Sarcophilus harrisii, were measured under standardized conditions by use of tritiated water. Total body water of lactating females was lower than in non- lactating animals, while water turnover rates per kilogram were not significantly different, due to a higher rate constant for lactating animals. Mean water turnover rates were considerably higher than predicted from other marsupial studies. Statistical analysis of data from 13 species of marsupial and 27 eutherian species showed habitat to have a far greater effect on standard water turnover rate than phylogeny.

Sign in / Sign up

Export Citation Format

Share Document