scholarly journals Generation of EHV‐1 pseudotype virus for cell tropism studies and virus‐neutralising assays

2021 ◽  
Vol 53 (S56) ◽  
pp. 55-56
Keyword(s):  
Cell Tropism ◽  
Pseudotype Virus

scholarly journals SARS-CoV-2 cell tropism and multiorgan infection

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Jia Liu ◽  
Yufeng Li ◽  
Qian Liu ◽  
Qun Yao ◽  
Xi Wang ◽  
...  
Keyword(s):  
Cell Tropism

scholarly journals Identification of the Envelope V3 Loop as a Determinant of a CD4-Negative Neuronal Cell Tropism for HIV-1

Virology ◽  
1996 ◽  
Vol 217 (2) ◽  
pp. 613-617 ◽  
Author(s):  
J.ROBERTO TRUJILLO ◽  
WEI-KUNG WANG ◽  
TUN-HOU LEE ◽  
MAX ESSEX
Keyword(s):  
Neuronal Cell ◽  
V3 Loop ◽  
Cell Tropism ◽  
Hiv 1

scholarly journals Cell tropism of wild-type measles virus is affected by amino acid substitutions in the P, V and M proteins, or by a truncation in the C protein

2004 ◽  
Vol 85 (10) ◽  
pp. 3001-3006 ◽  
Author(s):  
Naoko Miyajima ◽  
Makoto Takeda ◽  
Masato Tashiro ◽  
Koji Hashimoto ◽  
Yusuke Yanagi ◽  
...  
Keyword(s):  
Amino Acid ◽  
Measles Virus ◽  
M Protein ◽  
Amino Acid Difference ◽  
Cell Tropism ◽  
Wild Type ◽  
M Gene ◽  
Nucleotide Difference ◽  
Virus Growth ◽  
C Protein

Two nucleotide differences in the P/C/V and M genes between B95a cell- and Vero cell-isolated wild-type measles viruses (MV) have previously been found from the same patient. The nucleotide difference in the P/C/V gene resulted in an amino acid difference (M175I) in the P and V proteins and a 19 aa deletion in the C protein. The nucleotide difference in the M gene resulted in an amino acid difference (P64H) in the M protein. To verify this result and to examine further whether the amino acid difference or truncation is important for MV cell tropism, recombinant MV strains containing one of the two nucleotide substitutions, or both, were generated. It was found that the P64H substitution in the M protein was important for efficient virus growth and dissemination in Vero cells and that the M175I substitution in the P and V protein or truncation of the C protein was required for optimal growth.

Cell tropism and entry of porcine circovirus 2

2012 ◽  
Vol 164 (1-2) ◽  
pp. 43-45 ◽  
Author(s):  
H.J. Nauwynck ◽  
R. Sanchez ◽  
P. Meerts ◽  
D.J. Lefebvre ◽  
D. Saha ◽  
...  
Keyword(s):  
Porcine Circovirus ◽  
Cell Tropism ◽  
Porcine Circovirus 2

scholarly journals Altered Receptor Specificity and Cell Tropism of D222G Hemagglutinin Mutants Isolated from Fatal Cases of Pandemic A(H1N1) 2009 Influenza Virus

2010 ◽  
Vol 84 (22) ◽  
pp. 12069-12074 ◽  
Author(s):  
Yan Liu ◽  
Robert A. Childs ◽  
Tatyana Matrosovich ◽  
Stephen Wharton ◽  
Angelina S. Palma ◽  
...  
Keyword(s):  
Airway Epithelium ◽  
Influenza A ◽  
Cell Tropism ◽  
Ciliated Cells ◽  
Fatal Disease ◽  
Receptor Binding Site ◽  
Bronchial Epithelial ◽  
Human Airway Epithelium ◽  
Influenza A H1n1 ◽  
Microarray Analyses

ABSTRACT Mutations in the receptor-binding site of the hemagglutinin of pandemic influenza A(H1N1) 2009 viruses have been detected sporadically. An Asp222Gly (D222G) substitution has been associated with severe or fatal disease. Here we show that 222G variants infected a higher proportion of ciliated cells in cultures of human airway epithelium than did viruses with 222D or 222E, which targeted mainly nonciliated cells. Carbohydrate microarray analyses showed that 222G variants bind a broader range of α2-3-linked sialyl receptor sequences of a type expressed on ciliated bronchial epithelial cells and on epithelia within the lung. These features of 222G mutants may contribute to exacerbation of disease.

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