scholarly journals Identification of Streptococcus zooepidemicus strains from an outbreak of respiratory disease in Welsh mountain ponies

2021 ◽  
Vol 53 (S56) ◽  
pp. 28-29
Keyword(s):  
Respiratory Disease ◽  
Streptococcus Zooepidemicus

scholarly journals Characterization and Protective Immunogenicity of the SzM Protein of Streptococcus zooepidemicus NC78 from a Clonal Outbreak of Equine Respiratory Disease

2013 ◽  
Vol 20 (8) ◽  
pp. 1181-1188 ◽  
Author(s):  
Sridhar Velineni ◽  
John F. Timoney
Keyword(s):  
Respiratory Disease ◽  
Protective Antigen ◽  
Opportunistic Infections ◽  
New Caledonia ◽  
Fibrillar Structure ◽  
Streptococcus Zooepidemicus ◽  
Dependent Manner ◽  
Amino Acid Homology ◽  
Content Type ◽  
Streptococcus Equi

ABSTRACTStreptococcus zooepidemicusof Lancefield group C is a highly variable tonsillar and mucosal commensal that usually is associated with opportunistic infections of the respiratory tract of vertebrate hosts. More-virulent clones have caused epizootics of severe respiratory disease in dogs and horses. The virulence factors of these strains are poorly understood. The antiphagocytic protein SeM is a major virulence factor and protective antigen ofStreptococcus equi, a clonal biovar of an ancestralS. zooepidemicusstrain. Although the genome ofS. zooepidemicusstrain H70, an equine isolate, contains a partial homolog (szm) ofsem, expression of the gene has not been documented. We have identified and characterized SzM from an encapsulatedS. zooepidemicusstrain from an epizootic of equine respiratory disease in New Caledonia. The SzM protein of strain NC78 (SzMNC78) has a predicted predominantly alpha-helical fibrillar structure with an LPSTG cell surface anchor motif and resistance to hot acid. A putative binding site for plasminogen is present in the B repeat region, the sequence of which shares homology with repeats of the plasminogen binding proteins of human group C and G streptococci. Equine plasminogen is activated in a dose-dependent manner by recombinant SzMNC78. Only 23.20 and 25.46% DNA homology is shared with SeM proteins ofS. equistrains CF32 and 4047, respectively, and homology ranges from 19.60 to 54.70% for SzM proteins of otherS. zooepidemicusstrains. As expected, SzMNC78reacted with convalescent-phase sera from horses with respiratory disease associated with strains ofS. zooepidemicus. SzMNC78resembles SeM in binding equine fibrinogen and eliciting strong protective antibody responses in mice. Sera of vaccinated mice opsonizedS. zooepidemicusstrains NC78 and W60, the SzM protein of which shared partial amino acid homology with SzMNC78. We conclude that SzM is a protective antigen of NC78; it was strongly reactive with serum antibodies from horses during recovery fromS. zooepidemicus-associated respiratory disease.

scholarly journals Genomic Dissection of an Icelandic Epidemic of Equine Respiratory Disease

2016 ◽  
Author(s):  
Sigríður Björnsdóttir ◽  
Simon R. Harris ◽  
Vilhjálmur Svansson ◽  
Eggert Gunnarsson ◽  
Ólöf G. Sigurðardóttirr ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Respiratory Disease ◽  
Bacterial Species ◽  
Opportunistic Pathogen ◽  
Broad Host Range ◽  
Streptococcus Zooepidemicus ◽  
Epidemiological Investigation ◽  
Horse Population ◽  
Pathogenic Potential ◽  
Zoonotic Infections

ABSTRACTThe native horse population of Iceland has remained free of major infectious diseases. Between May and July 2010 an epidemic of respiratory disease swept through the population. Initial microbiological investigations ruled out known equine viral agents as the cause of the infections, but identified the opportunistic pathogenStreptococcus zooepidemicusas being frequently isolated from diseased animals. This diverse bacterial species has a broad host range and is usually regarded as a commensal of horses. By genome sequencingS. zooepidemicusrecovered from horses during the epidemic we show that although multiple clones ofS. zooepidemicuswere present in the population, one particular clone, ST209, was responsible for the epidemic. Concurrent with the epidemic, ST209 caused zoonotic infections, highlighting the pathogenic potential of this clone. Phylogenetic analysis suggests that the original ST209 strain entered Iceland in late 2008 or early 2009. Epidemiological investigation revealed that the incursion of this strain into a training yard that utilized a submerged treadmill between the 5thand 19thof February 2010 was a critical trigger for the ensuing epidemic of disease, provided a nidus for the infection of multiple horses, and subsequent distribution of these animals to multiple sites in Iceland.

Characterization of a mucoid clone of Streptococcus zooepidemicus from an epizootic of equine respiratory disease in New Caledonia

2014 ◽  
Vol 200 (1) ◽  
pp. 82-87 ◽  
Author(s):  
Sridhar Velineni ◽  
Denise Desoutter ◽  
Anne-Marie Perchec ◽  
John F. Timoney
Keyword(s):  
Respiratory Disease ◽  
New Caledonia ◽  
Streptococcus Zooepidemicus

GERD Tied to Worse Infant Respiratory Disease

2012 ◽  
Vol 46 (5) ◽  
pp. 4-5
Author(s):  
MIRIAM E. TUCKER
Keyword(s):  
Respiratory Disease

Bedeutung der allergologischen Abklärung bei Asthma und COPD

2014 ◽  
Vol 71 (5) ◽  
pp. 267-274
Author(s):  
Judith A. Schneider Spence ◽  
Andreas J. Bircher ◽  
Kathrin Scherer Hofmeier
Keyword(s):  
Respiratory Disease ◽  
Asthma Bronchiale ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Work Up

Während eine allergologische Abklärung im Work-Up eines Asthma bronchiale inbegriffen sein sollte, wird die chronisch obstruktive Pneumopathie nicht spontan mit einer atopischen Diathese in Zusammenhang gebracht. Anamnese, Klinik, das Vorhandensein weiterer atopischer Krankheiten sowie Prickteste und die serologische Messung von spezifischen IgE-Antikörpern geben Hinweise auf eine allergische Genese einer akuten oder chronischen Lungenkrankheit. Der Stickoxidwert in der Ausatemluft (FeNO-Messung) kann durch die Infiltration von Eosinophilen in die Bronchialwand beim allergischen Phänotyp des Asthma bronchiale erhöht sein (TH2-gewichteter Phänotyp). Eine Abhängigkeit der Beschwerden vom Arbeitsplatz muss evaluiert werden. Neben dem allergischen Typ des Asthma bronchiale soll auch an eine Aspirin-exacerbated-respiratory disease (AERD) gedacht werden. Aufgrund der überlappenden pathophysiologischen Grundlagen und der Symptomatik zwischen Asthma bronchiale und der chronisch obstruktiven Pneumopathie ist die Zuweisung zum Allergologen allenfalls auch bei einem COPD-Patienten indiziert.

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