Effect of omeprazole and sucralfate on gastrointestinal injury in a fasting/NSAID model

2021 ◽  
Author(s):  
Rebecca C. Bishop ◽  
Ann M. Kemper ◽  
Pamela A. Wilkins ◽  
Annette M. McCoy
Keyword(s):  
Gastrointestinal Injury

Using Digestive Fluid Biomarkers to Predict Acute Gastrointestinal Injury in Critically Ill Patients: A Pilot Study

2018 ◽  
Vol 27 (6) ◽  
pp. 504-507
Author(s):  
Cheng Minhua ◽  
Gao Tao ◽  
Xi Fengchan ◽  
Yu Wenkui
Keyword(s):  
Intensive Care ◽  
Immunoglobulin A ◽  
Interleukin 10 ◽  
Secretory Immunoglobulin A ◽  
Gastrointestinal Injury ◽  
Gastrointestinal Failure ◽  
Acute Gastrointestinal Injury ◽  
Secretory Immunoglobulin ◽  
Grade Iii ◽  
Digestive Fluid

Background Acute gastrointestinal injury is associated with significantly increased mortality in critically ill patients. However, markers for measuring acute gastrointestinal injury are neither sensitive nor specific. Objective To determine whether enzymes in digestive fluid are predictive of the severity of acute gastrointestinal injury. Methods A prospective observational study was conducted between June 2015 and December 2015 in a surgical intensive care unit. Enrolled patients were classified by acute gastrointestinal injury grade according to the 2012 European Society of Intensive Care Medicine system. Digestive fluid was collected through nasointestinal tubes and analyzed 24 hours after the diagnosis of acute gastrointestinal injury. Intestinal markers of injury (pH, interleukin 6, interleukin 10, tumor necrosis factor α, and secretory immunoglobulin A) were measured in digestive fluid. Results Of the 76 patients included, acute gastrointestinal injury was grade I in 41, grade II in 20, grade III in 8, and grade IV in 7. Secretory immunoglobulin A was an independent predictor of grade III acute gastrointestinal injury. When data from patients with grades I and II injury and patients with grades III and IV injury were grouped together, analysis revealed that pH, interleukin 10, and secretory immunoglobulin A were independent predictors of acute gastrointestinal failure. Conclusions Secretory immunoglobulin A was predictive of grade III acute gastrointestinal injury. Digestive fluid markers of injury (pH, interleukin 10, and secretory immunoglobulin A) were predictors of acute gastrointestinal failure. Further study is required to determine if other markers are specific or sensitive for acute gastrointestinal injury.

scholarly journals COX-2: A Pivotal Enzyme in Mucosal Protection and Resolution of Inflammation

2006 ◽  
Vol 6 ◽  
pp. 577-588 ◽  
Author(s):  
John L. Wallace
Keyword(s):  
Digestive System ◽  
Intestinal Inflammation ◽  
Mucosal Protection ◽  
Cox Inhibitors ◽  
Gastrointestinal Injury ◽  
Inflammatory Drugs ◽  
Long Term Consequences ◽  
Cox 2 ◽  
Cox 2 Inhibitors

The discovery of a second form of cyclooxygenase, COX-2, led to a burst of research aimed at the development of nonsteroidal anti-inflammatory drugs that would not damage the gastrointestinal tract. In the years since, this promise has only been partially fulfilled. Selective COX-2 inhibitors cause less gastric damage than conventional, nonselective COX inhibitors, but their use is still associated with significant gastrointestinal injury, and with toxicity in the renal and cardiovascular systems. COX-2 is now recognized as a source of mediators that produce many beneficial and detrimental effects in the digestive system. In this review, the roles of COX-2 in mucosal defense and injury are discussed. Furthermore, contributions of COX-2–derived products to the long-term consequences of intestinal inflammation, including cancer, are reviewed.

scholarly journals Coin battery modification to prevent Gastrointestinal injury from current flow

2012 ◽  
Vol 18 (Suppl 1) ◽  
pp. A138.1-A138
Author(s):  
M Baum Eli ◽  
R Baum Carl
Keyword(s):  
Current Flow ◽  
Gastrointestinal Injury

scholarly journals Nonsurgical Management of Severe Esophageal and Gastric Injury Following Alkali Ingestion

2007 ◽  
Vol 21 (11) ◽  
pp. 757-760 ◽  
Author(s):  
Ramy D Abaskharoun ◽  
William T Depew ◽  
Lawrence C Hookey
Keyword(s):  
Functional Results ◽  
Initial Evaluation ◽  
Acid Suppression ◽  
Gastric Injury ◽  
Endoscopic Management ◽  
Gastrointestinal Injury ◽  
Nonsurgical Management ◽  
Ingestion Of Caustic Substances ◽  
Alkali Ingestion

The ingestion of caustic substances may result in significant gastrointestinal injury. Endoscopy can play a major role in the initial evaluation and subsequent therapy of such injuries. The case of a 50-year-old man who ingested an alkaline floor stripper is described, including the endoscopic management of esophageal and pyloric strictures, with good functional results. The role of endoscopy, steroids and acid suppression in the management of such patients is also explored.

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