scholarly journals Penetration of topically administered dexamethasone disodium phosphate and prednisolone acetate into the normal equine ocular fluids

2021 ◽  
Author(s):  
Hanneke Hermans ◽  
Els M.H. van den Berg ◽  
Inge J.M. Slenter ◽  
Dax J.C. Vendrig ◽  
Lilian L. de Nijs‐Tjon ◽  
...  
Keyword(s):  
Prednisolone Acetate ◽  
Disodium Phosphate ◽  
Ocular Fluids

ÜBER DIE ANTAGONISTISCHE WIRKUNG VON TRIJODTHYRONIN UND PROGESTERON AUF DEN PREDNISOLONEFFEKT AM EPIPHYSENKNORPEL (PRÜFUNG DER REISSFESTIGKEIT)

1963 ◽  
Vol 42 (1) ◽  
pp. 29-38 ◽  
Author(s):  
L. Ther ◽  
H. Schramm ◽  
G. Vogel
Keyword(s):  
Tensile Strength ◽  
Dose Response ◽  
Single Injection ◽  
Relative Effectiveness ◽  
Prednisolone Acetate ◽  
Response Curves ◽  
Deoxycorticosterone Acetate ◽  
Weight Range ◽  
Diuretic Action ◽  
Maximal Load

ABSTRACT Longitudinal tension exerted on a killed rat's femur results always in rupture on the same place viz: the distal epiphyseal line. The power required to produce this effect can be measured with a simple dynamometer. The tensile strength increases with advancing age and during exsiccation (thirst). In untreated rats (weight range 100–120 g) this value amounts to about 1.5–1.8 kg. Tensile strength of the femoral epiphyseal line may be influenced by hormones. Corticosteroids such as prednisolone acetate and cortisol acetate increase the level of maximal load to more than 2.0 kg. In general the effect of a single injection reaches a climax after 48 hours. Dose-response-curves can be established and relative effectiveness may be gathered therefrom. Deoxycorticosterone acetate likewise increases tensile strength in spite of the fact that contrary to prednisolone exhibiting diuretic action this compound has a water retaining effect. Triiodothyronine and progesterone when given alone produce a slight decrease in tensile strength. The effect of prednisolone when given simultaneously with one of these two compounds is antagonized: this phenomenon is more pronounced in the case of triiodothyronine.

Comparison of Safety and Efficacy of Prednisolone Acetate Vs Difluprednate Vs Loteprednol Eye drops Post Cataract Surgery

2020 ◽  
Vol 23 (15) ◽  
Author(s):  
Aaliya Ambereen ◽  
Shankar C ◽  
Adnan Mohamed Matheen ◽  
Premnath G ◽  
Stephen Sudhakar
Keyword(s):  
Cataract Surgery ◽  
Prednisolone Acetate ◽  
Eye Drops ◽  
Safety And Efficacy

scholarly journals Evaluation of a Sustained-Release Prednisolone Acetate Biodegradable Subconjunctival Implant in a Non-Human Primate Model

2017 ◽  
Vol 6 (5) ◽  
pp. 9 ◽  
Author(s):  
Yu-Chi Liu ◽  
Anthony Herr Cheun Ng ◽  
Xu Wen Ng ◽  
Peng Yan ◽  
Subbu S. Venkatraman ◽  
...  
Keyword(s):  
Sustained Release ◽  
Prednisolone Acetate ◽  
Primate Model ◽  
Human Primate

EFFECTS OF ADRENALECTOMY ON REPRODUCTION IN THE MOUSE

1980 ◽  
Vol 86 (1) ◽  
pp. 155-164
Author(s):  
BARBARA M. WHITE ◽  
A. A. GIDLEY-BAIRD ◽  
C. W. EMMENS
Keyword(s):  
Single Injection ◽  
Sesame Seed ◽  
Linear Increase ◽  
Prednisolone Acetate ◽  
Methyl Prednisolone ◽  
Ovariectomized Mice ◽  
Significant Difference ◽  
Sesame Seed Oil ◽  
Pregnant Mice ◽  
Desoxycorticosterone Acetate

Survival of mice treated with sesame seed oil after adrenalectomy was very low and suggested no beneficial effect, whereas treatment with progesterone improved the chances of survival. Treatment with desoxycorticosterone acetate (DOCA) and methyl prednisolone acetate also increased the number of animals surviving after adrenalectomy. The corticosteroids were significantly more effective in ensuring survival than was progesterone. There was no significant difference in survival between mice receiving a single injection of 10 mg DOCA and those being given an injection of 1·0 mg DOCA per day for 3 days after the operation. To ensure minimum interference of exogenous corticosteroid with the experimental investigation, animals routinely received only a single injection of 1·0 mg DOCA after the operation. The chance of survival after adrenalectomy was higher in pregnant than in non-pregnant mice. There was a significant linear increase in survival during the first 5 days of pregnancy. Progesterone and prolactin both appeared to be involved in increasing the chance of survival in adrenalectomized pregnant mice. Adrenalectomy had no effect on the number of mice mating and ovulating. Adrenalectomized mice were apparently having normal cycles and 4 weeks after adrenalectomy they were able to mate and ovulate. Compensatory ovulation was seen in hemi-ovariectomized mice and was not abolished by adrenalectomy. Implantation was also unaffected by the operation.

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