Immunohistochemical analysis of laryngeal muscle of horses clinically affected with recurrent laryngeal neuropathy

Equine Veterinary Journal ◽

10.1111/evj.13362 ◽

2020 ◽

Author(s):

Catherine M. Steel ◽

Elizabeth A. Walmsley ◽

Garry A. Anderson ◽

Chantal A. Coles ◽

Benjamin Ahern ◽

...

Keyword(s):

Immunohistochemical Analysis ◽

Laryngeal Muscle

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Review for "Immunohistochemical analysis of laryngeal muscle of horses clinically affected with recurrent laryngeal neuropathy"

10.1111/evj.13362/v1/review3 ◽

2020 ◽

Author(s):

Ian Fulton

Keyword(s):

Immunohistochemical Analysis ◽

Laryngeal Muscle

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Tacrolimus enhances the recovery of normal laryngeal muscle fibre distribution after reinnervation

The Journal of Laryngology & Otology ◽

10.1017/s0022215112001788 ◽

2012 ◽

Vol 126 (11) ◽

pp. 1155-1158 ◽

Cited By ~ 2

Author(s):

P Gorphe ◽

N Guerout ◽

M Birchall ◽

G Terenghi ◽

J-P Marie

Keyword(s):

Muscle Fibre ◽

Low Dose ◽

Immunohistochemical Analysis ◽

Muscle Fibre Types ◽

Muscle Fibres ◽

Healthy Group ◽

Laryngeal Muscle ◽

Laryngeal Reinnervation ◽

Posterior Cricoarytenoid ◽

Resection And Anastomosis

AbstractObjectives:To assess the recovery of various muscle fibre types in the posterior cricoarytenoid muscle after laryngeal reinnervation in the rat, and to determine the influence of tacrolimus on this process.Methods:Four groups of rats underwent resection and anastomosis of the left vagus nerve, and were administered either tacrolimus at a low dose or an immunosuppressive dose, or cyclosporin A at a low dose or an immunosuppressive dose. A fifth group received surgery alone, and a sixth group received neither surgery nor drug treatment (healthy group). Muscles were removed for immunohistochemical analysis 45 days after surgery.Results:There was no difference in the proportion of types 1, 2a and 2b muscle fibres, comparing the immunosuppressive tacrolimus group and the healthy group, whereas there were fewer type 1 fibres in the group receiving surgery alone, compared with the healthy group (7 vs 12.1 per cent, respectively; p = 0.0303).Conclusion:Tacrolimus enhanced the recovery of normal laryngeal muscle fibres after reinnervation in the rat, indicating a possible role in laryngeal transplantation.

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