Exhaled breath condensate hydrogen peroxide, pH and leukotriene B4 are associated with lower airway inflammation and airway cytology in the horse

2018 ◽  
Vol 51 (1) ◽  
pp. 24-32 ◽  
Author(s):  
S. du Preez ◽  
S. L. Raidal ◽  
G. S. Doran ◽  
M. Prescott ◽  
K. J. Hughes
Keyword(s):  
Hydrogen Peroxide ◽  
Airway Inflammation ◽  
Exhaled Breath Condensate ◽  
Leukotriene B4 ◽  
Lower Airway ◽  
Exhaled Breath ◽  
Breath Condensate

Collection of exhaled breath condensate and analysis of hydrogen peroxide as a potential marker of lower airway inflammation in cats

2005 ◽  
Vol 169 (3) ◽  
pp. 385-396 ◽  
Author(s):  
Nathalie Kirschvink ◽  
David Marlin ◽  
François Delvaux ◽  
Jérôme Leemans ◽  
Cécile Clercx ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Airway Inflammation ◽  
Exhaled Breath Condensate ◽  
Lower Airway ◽  
Exhaled Breath ◽  
Potential Marker ◽  
Breath Condensate

scholarly journals Using the Inflammacheck Device to Measure the Level of Exhaled Breath Condensate Hydrogen Peroxide in Patients With Asthma and Chronic Obstructive Pulmonary Disease (The EXHALE Pilot Study): Protocol for a Cross-Sectional Feasibility Study (Preprint)

2017 ◽  
Author(s):  
Daniel M Neville ◽  
Carole Fogg ◽  
Thomas P Brown ◽  
Thomas L Jones ◽  
Eleanor Lanning ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Pilot Study ◽  
Airway Inflammation ◽  
Exhaled Breath Condensate ◽  
Symptom Control ◽  
Chronic Obstructive ◽  
Exhaled Breath ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Breath Condensate

BACKGROUND Asthma and Chronic Obstructive Pulmonary Disease (COPD) are common conditions that affect over 5 million people in the United Kingdom. These groups of patients suffer significantly from breathlessness and recurrent exacerbations that can be difficult to diagnose and go untreated. A common feature of COPD and asthma is airway inflammation that increases before and during exacerbations. Current methods of assessing airway inflammation can be invasive, difficult to perform, and are often inaccurate. In contrast, measurement of exhaled breath condensate (EBC) hydrogen peroxide (H2O2) is performed during normal tidal breathing and is known to reflect the level of global inflammation in the airways. There is a need for novel tools to diagnose asthma and COPD earlier and to detect increased airway inflammation that precedes an exacerbation. OBJECTIVE The aim of this study was to explore the use of a new handheld device (called Inflammacheck) in measuring H2O2 levels in EBC. We will study whether it can measure EBC H2O2 levels consistently and whether it can be used to differentiate asthma and COPD from healthy controls. METHODS We will perform a cross-sectional, feasibility, pilot study of EBC H2O2 levels, as measured by Inflammacheck, and other markers of disease severity and symptom control in patients with asthma and COPD and volunteers with no history of lung disease. Participants will be asked to provide an exhaled breath sample for measurement of their EBC H2O2 using Inflammacheck. The result will be correlated with disease stage, spirometry, fractional exhaled nitric oxide (FeNO), and symptom control scores. RESULTS This study’s recruitment is ongoing; it is anticipated that the results will be available in 2018. CONCLUSIONS The EXhaled Hydrogen peroxide As a marker of Lung diseasE (EXHALE) pilot study will provide an evaluation of a new method of measuring EBC H2O2. It will assess the device’s consistency and ability to distinguish airway inflammation in asthma and COPD compared with healthy controls.

scholarly journals Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease

2017 ◽  
Vol 9 (2) ◽  
pp. 126 ◽  
Author(s):  
Aleksandra Wardzyńska ◽  
Joanna S. Makowska ◽  
Małgorzata Pawełczyk ◽  
Aleksandra Piechota-Polańczyk ◽  
Marcin Kurowski ◽  
...  
Keyword(s):  
Exhaled Breath Condensate ◽  
Airway Disease ◽  
Lower Airway ◽  
Exhaled Breath ◽  
Asthmatic Patients ◽  
Breath Condensate

scholarly journals Chemiluminescent Measurement of Hydrogen Peroxide in the Exhaled Breath Condensate of Healthy and Asthmatic Adults

2020 ◽  
Vol 92 (21) ◽  
pp. 14594-14600
Author(s):  
Miguel E. Quimbar ◽  
Steven Q. Davis ◽  
Sherif T. Al-Farra ◽  
Amanda Hayes ◽  
Valentina Jovic ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Breath Condensate
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