scholarly journals A systematic review and meta-analysis of the efficacy of furosemide for exercise-induced pulmonary haemorrhage in Thoroughbred and Standardbred racehorses

2015 ◽  
Vol 47 (3) ◽  
pp. 341-349 ◽  
Author(s):  
S. L. Sullivan ◽  
T. Whittem ◽  
P. S. Morley ◽  
K. W. Hinchcliff
HORMONES ◽  
2019 ◽  
Vol 18 (4) ◽  
pp. 383-393
Author(s):  
Jun Hyun Bae ◽  
Seong Eun Kwak ◽  
Ji Hyun Lee ◽  
Zhang Yangjie ◽  
Wook Song

Author(s):  
Elias de França ◽  
Fábio Santos Lira ◽  
Marcio Flávio Ruaro ◽  
Vinicius Barroso Hirota ◽  
Paula A. Faria Waziry ◽  
...  

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect beta-alanine (BA) or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). We searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. We search papers published before May 2018.  A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young (21y) sedentary, recreationally active or athletic participants. After a chorionic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, BA/carnosine supplementation increased total antioxidant capacity (TAC) and glutathione concentrations while decreased pro-oxidant markers and superoxide dismutase (SOD) activity. BA or carnosine supplementation did not prevent the increase in peroxidation markers (e.g., 8-isoprostane, protein carbonyl or malonaldehyde). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in pro-oxidants, treatment did not decrease measured values of peroxidation markers.


2019 ◽  
Vol 77 (9) ◽  
pp. 630-645 ◽  
Author(s):  
Taylor K Bloedon ◽  
Rock E Braithwaite ◽  
Imogene A Carson ◽  
Dorothy Klimis-Zacas ◽  
Robert A Lehnhard

Abstract Context Supplementing with fruits high in anthocyanins to reduce exercise-induced oxidative stress and inflammation has produced mixed results. Objective This systematic review and meta-analysis aims to discuss the impact of whole fruits high in anthocyanins, including processing methods and the type and amount of fruit, on inflammation and oxidative stress. Data Sources PICOS reporting guidelines and a customized coding scheme were used to search 5 databases (SPORTDiscus, Science Direct, Web of Science [BIOSIS], Medline [Pubmed], and the Cochrane Collaboration) with additional cross-referencing selection. Data Extraction A random-effects meta-analysis was used to measure effects of the fruit supplements with 3 statistics; the QTotal value based on a χ2 distribution, τ2 value, and I2 value were used to determine homogeneity of variances on 22 studies (out of 807). Outliers were identified using a relative residual value. Results A small significant negative summary effect across the sum of all inflammatory marker outcomes (P < 0.001) and a moderate negative effect for the sum of all oxidative stress marker outcomes (P = 0.036) were found. Moderator analyses did not reveal significant (P > 0.05) differences between subgrouping variables. Conclusions Results indicate that consumption of whole fruit high in anthocyanins can be beneficial for reducing inflammation and oxidative stress.


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