Can high-resolution peripheral quantitative computed tomography imaging of subchondral and cortical bone predict condylar fracture in Thoroughbred racehorses?

2014 ◽  
Vol 47 (4) ◽  
pp. 428-432 ◽  
Author(s):  
G. D. Trope ◽  
A. Ghasem-Zadeh ◽  
G. A. Anderson ◽  
E. J. Mackie ◽  
R. C. Whitton
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Cortical Bone ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Computed Tomography Imaging ◽  
Condylar Fracture ◽  
Tomography Imaging ◽  
Thoroughbred Racehorses

scholarly journals Acromegaly Has a Negative Influence on Trabecular Bone, But Not on Cortical Bone, as Assessed by High-Resolution Peripheral Quantitative Computed Tomography

2013 ◽  
Vol 98 (4) ◽  
pp. 1734-1741 ◽  
Author(s):  
Miguel Madeira ◽  
Leonardo Vieira Neto ◽  
Francisco de Paula Paranhos Neto ◽  
Inayá Corrêa Barbosa Lima ◽  
Laura Maria Carvalho de Mendonça ◽  
...  
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Negative Influence

Definition for Rheumatoid Arthritis Erosions Imaged with High Resolution Peripheral Quantitative Computed Tomography and Interreader Reliability for Detection and Measurement

2016 ◽  
Vol 43 (10) ◽  
pp. 1935-1940 ◽  
Author(s):  
Cheryl Barnabe ◽  
Dominique Toepfer ◽  
Hubert Marotte ◽  
Ellen-Margrethe Hauge ◽  
Andrea Scharmga ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Computed Tomography ◽  
High Resolution ◽  
Cortical Bone ◽  
Intraclass Correlation ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Maximum Width ◽  
Trabecular Bone Loss ◽  
Axial Depth

Objective.High-resolution peripheral quantitative computed tomography (HR-pQCT) sensitively detects erosions in rheumatoid arthritis (RA); however, nonpathological cortical bone disruptions are potentially misclassified as erosive. Our objectives were to set and test a definition for pathologic cortical bone disruptions in RA and to standardize reference landmarks for measuring erosion size.Methods.HR-pQCT images of metacarpophalangeal joints of RA and control subjects were used in an iterative process to achieve consensus on the definition and reference landmarks. Independent readers (n = 11) applied the definition to score 58 joints and measure pathologic erosions in 2 perpendicular multiplanar reformations for their maximum width and depth. Interreader reliability for erosion detection and variability in measurements between readers [root mean square coefficient of variation (RMSCV), intraclass correlation (ICC)] were calculated.Results.Pathologic erosions were defined as cortical breaks extending over a minimum of 2 consecutive slices in perpendicular planes, with underlying trabecular bone loss and a nonlinear shape. Interreader agreement for classifying pathologic erosions was 90.2%, whereas variability for width and depth erosion assessment was observed (RMSCV perpendicular width 12.3%, axial width 20.6%, perpendicular depth 24.0%, axial depth 22.2%; ICC perpendicular width 0.206, axial width 0.665, axial depth 0.871, perpendicular depth 0.783). Mean erosion width was 1.84 mm (range 0.16–8.90) and mean depth was 1.86 mm (range 0.30–8.00).Conclusion.We propose a new definition for erosions visualized with HR-pQCT imaging. Interreader reliability for erosion detection is good, but further refinement of selection of landmarks for erosion size measurement, or automated volumetric methods, will be pursued.

High resolution peripheral quantitative computed tomography (HR-pQCT) und die klinische Relevanz der Resultate

2013 ◽  
Vol 22 (01) ◽  
pp. 13-17
Author(s):  
J. M. Patsch ◽  
R. Kocijan ◽  
H. Resch ◽  
J. Haschka
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Klinische Relevanz

ZusammenfassungKnochenstabilität ist durch Knochenvolumen und Mikroarchitektur des Knochens determiniert. Mittels HR-pQCT (high resolution peripheral quantitative computed tomography) steht eine nicht invasive Methode zur Verfügung, um die Mikroarchitektur des Knochens darzustellen. Die Resultate aus zahlreichen Studien geben Rückschlüsse auf unterschiedliche Strukturalterationen im Rahmen von Erkrankungen, die mit einem erhöhten Frakturrisiko einhergehen. Die Knochendichtemessung mittels DXA spiegelt das Frakturrisiko oft nicht adäquat wider. Umso entscheidender ist es, Risikofaktoren in der Wahl der Therapie zu berücksichtigen. Die klinische Relevanz der Resultate aus HR-pQCT-Messungen besteht derzeit dahingehend, dass wertvolle Informationen über Veränderungen der Mikroarchitektur auf Forschungsebene erhoben werden.

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