Cardiac arrhythmias as a potential sign of systemic disease: Which laboratory tests are useful?

2021 ◽  
Author(s):  
A. Decloedt
Keyword(s):  
Cardiac Arrhythmias ◽  
Laboratory Tests ◽  
Systemic Disease ◽  
Potential Sign

scholarly journals Bilateral Sesamoiditis as First Manifestation of Gout

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Daniel de Oliveira Beraldo ◽  
Sasha Duarte ◽  
Gustavo Pacheco ◽  
Rodrigo Barbosa ◽  
Carolina Mendes ◽  
...  
Keyword(s):  
Laboratory Tests ◽  
Case Reports ◽  
Systemic Disease ◽  
Positive Family History ◽  
Rare Condition ◽  
Dual Energy ◽  
Male Athlete ◽  
Important Differential Diagnosis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Sesamoiditis secondary to gout is an extremely rare condition with few case reports in the literature. It is an important differential diagnosis because the treatment depends on targeted therapy, unlike the main causes of sesamoiditis that often involves immobilization with special orthoses and prescription of anti-inflammatory drugs. We report here a case of a 38-year-old male, athlete, with bipartite medial sesamoid, who had insidious pain in the base of the left hallux. Laboratory tests showed no alterations, and imaging examinations demonstrated sesamoiditis with suspicion of stress fracture. The patient was initially prescribed an immobilization boot and analgesic and anti-inflammatory drugs, but he did not respond to the measures taken. After the onset of the same condition in the contralateral foot and getting the same imaging findings, we began an investigation of systemic disease, focusing on gout, because of a positive family history, which was confirmed by dual-energy computed tomography.

scholarly journals Evaluation of the Screening Laboratory Tests for Endocrine Diseases among the Patients of the Oral Medicine Department of Yazd Dental School in Academic Year of 2015-2016

2020 ◽  
Author(s):  
Hakimeh Ahadian ◽  
Hoda Farmanara
Keyword(s):  
Laboratory Tests ◽  
Current System ◽  
Systemic Disease ◽  
Dental School ◽  
Primary Concern ◽  
Oral Medicine ◽  
Chi Square ◽  
Medicine Department ◽  
Significant Difference ◽  
Chi Square Analysis

Introduction: The primary concern with the current system of ordering laboratory tests is that many tests are obtained that do not contribute beneficially to patient care. Unnecessary tests create additional risks, inefficient operating room programs, and unnecessary costs for the patient.UnnecThe aim of this study was to determine the frequency distribution of results of endocrine ordered lab tests among the patients of Oral Medicine Department Of Yazd Dental School in the years 2015-2016. Methods: This cross-sectional descriptive study was performed on 273 patients referred to the Department of Oral and Maxillofacial Diseases from October 2015 to September 2016. Demographic data, systemic disease and their types, medical history, clinical examinations, the type of requested tests and their reasons were analyzed using SPSS V.22 software and Chi-square analysis. Results: Based on the results of this study, the mean age of the patients studied was 40 years, and the standard deviation of the age of the individuals was 14.3 (40± 14.3) with the age range of 6-83 years. Chi-square analysis showed a significant correlation between test results of FBS, HbA1c, T3, TSH, with the age of the patients (P <0.05). In addition, the results of 2hpp showed that there was a significant difference between male and female patients (P <0.05). Conclusion: The most results of endocrine laboratory tests of patients at this time were normal, which can indicate the readiness of clients to tolerate dental treatments.

scholarly journals Ischemic stroke in children: a study of the associated alterations

2004 ◽  
Vol 62 (3a) ◽  
pp. 618-625 ◽  
Author(s):  
Josiane Ranzan ◽  
Newra Tellechea Rotta
Keyword(s):  
Risk Factor ◽  
Ischemic Stroke ◽  
Laboratory Tests ◽  
Systemic Disease ◽  
Delayed Diagnosis ◽  
Arterial Ischemic Stroke ◽  
Ischemic Event ◽  
Causative Factors ◽  
Coagulation Proteins ◽  
The Subject

Arterial ischemic stroke (AIS) in children is a relatively rare disease, not yet clearly understood and with a multifactored etiology. It can cause a severe impact on the child and be the first manifestation of a systemic disease. Delayed diagnosis is still common and research on the subject in our field practically does not exist. Prothrombotic disorders have been described as important causative factors of the ischemic event in children. Forty-six patients from zero to 18 years of age diagnosed with AIS were studied in the period between March 2002 and September 2003. Laboratory tests were realised including coagulation proteins and echocardiogram. AIS of the newborn occurred in 37% of the cases. Focal seizures and hemiparesis were the most frequent symptoms; 40% of the patients presented prior pathologies. Abnormalities of the S and C proteins occurred in 22% and 17%. Associated alterations, particularly those that generate a hypercoagulability state, indicate more than one risk factor for this disease in childhood.

Laboratory medicine in pediatric lupus

2010 ◽  
Vol 01 (01) ◽  
pp. 045-051
Author(s):  
Antonio La Cava
Keyword(s):  
Risk Factors ◽  
Laboratory Testing ◽  
Laboratory Tests ◽  
Systemic Disease ◽  
Clinical Manifestations ◽  
Laboratory Medicine ◽  
Routine Laboratory ◽  
Specific Risk ◽  
Broad Variety ◽  
Pediatric Lupus

AbstractPediatric lupus encompasses a broad variety of clinical manifestations of a systemic disease. Routine laboratory testing, autoantibodies, and complement levels can confirm the diagnosis and help monitoring and therapy of the disease, to ultimately improve outcomes. Additionally, tests can help to identify subsets of patients with specific risk factors and/or the involvement of selected organs/systems. The availability, refinement and accuracy of laboratory tests are instrumental to improve the diagnosis, treatment and prognosis of pediatric lupus patients.

scholarly journals FRI0643-HPR CARDIOVASCULAR DISEASE AMONG PATIENTS WITH RHEUMATOID ARTHRITIS COMPARED WITH THOSE WITH OSTEOARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 925.3-926
Author(s):  
F. Wang ◽  
B. Mukerji ◽  
R. Markert ◽  
V. Mukerji
Keyword(s):  
Rheumatoid Arthritis ◽  
Atrial Fibrillation ◽  
Cardiovascular Disease ◽  
Cardiac Arrhythmias ◽  
European Heart Journal ◽  
Smoking Status ◽  
Medical Center ◽  
Systemic Disease ◽  
Patient Characteristics ◽  
Population Based

Background:Rheumatoid arthritis (RA) is a chronic immune mediated systemic disease known to affect multiple organs. It is known that cardiovascular disease accounts for nearly half the mortality among RA patients1,2,3. Osteoarthritis (OA), on the other hand, is not an inflammatory arthritis. No prior study has compared the prevalence of cardiovascular disease (CVD) among these two groups of patients.Objectives:The purpose of this study was to compare the prevalence of CVD among U.S. veterans with RA versus those with OA.Methods:The study was conducted in a metropolitan Veterans Affairs Medical Center in the U.S. Information was collected from 125 consecutive patients with RA and 125 consecutive patients with OA as they presented to the clinic. Patient characteristics were noted as well as the presence of CVD and certain subgroups: Cardiac arrhythmias4, coronary artery disease (CAD), congestive heart failure (CHF), cerebrovascular accident (CVA), abdominal aortic aneurysm (AAA), peripheral vascular disease (PVD), deep vein thrombosis (DVT), pulmonary embolism (PE), or any other form of embolism. The chi square test and the mann-whitney test were used for statistical analyses.Results:Patient characteristics did not differ between the two groups for age, race, smoking status, or for the presence of hypertension or diabetes. There were more women in the RA group. The OA group had a higher BMI and a higher prevalence of hyperlipidemia. RA patients compared to OA patients had a higher incidence of CVD as a whole (60% vs. 42%, p < 0.004) and of cardiac arrhythmias (33.6% vs. 13.6%, p = 0.001). There was no difference between the 2 groups for the incidence of CAD, CHF, CVA, AAA, PVD or DVT/PE. RA seropositive and seronegative patients did not differ in the prevalence of CVD. RA duration was not related to the increased prevalence of CVD. Among the cardiac arrhythmias, patients with RA had a higher prevalence of atrial fibrillation (19.2% vs. 8.8%, p < 0.03), and arrhythmias requiring pacemaker or defibrillator implant (12.8% vs. 4.0%, p < 0.02).Conclusion:The findings of this study demonstrate that our patients with RA have a statistically higher prevalence of CVD compared to OA patients. Among the subgroups, RA patients had a higher prevalence of cardiac arrhythmias, specifically atrial fibrillation and arrhythmias requiring pacemaker or defibrillator implant.References:[1] England BR, et al. Cause-specific mortality in male US veterans with rheumatoid arthritis. Arthritis Care Res (Hobboken); 68: 36-45 2016[2] Avina-Zubiets JA, et al. Risk of incident cardiovascular events in patients with rheumatoid arthritis: a met-analysis of observational studies. Ann Rheum Dis 2012; 71: 1524-1529.[3] Maradit-Kremers,H et al. Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: A population-based cohort study. Arthritis Rheum. 2005; 52: 402-411[4] Lazzerini PE, Capechi L et al. Systemic Inflammation and arrhythmic risk: lessons from rheumatoid arthritis. European Heart Journal; 2017, 38: 1717-1727Disclosure of Interests:None declared

scholarly journals Tracking of The Most Significant Laboratory Parameters For The Identification of Covid-19: An Overview on The Different Blood Tests

2020 ◽  
pp. 112-118
Author(s):  
Seenaa Ali
Keyword(s):  
Laboratory Tests ◽  
Systemic Disease ◽  
Laboratory Data ◽  
Virus Transmission ◽  
Albumin Level ◽  
Laboratory Findings ◽  
Multiple Systems ◽  
Laboratory Parameters ◽  
Infected People ◽  
Novel Coronavirus

An outbreak of 2019 novel coronavirus disease (COVID-19) began in China during December 2019 which unexpectedly spread to other countries and caused high mortality all over the world. COVID-19 disease primarily manifests as a respiratory tract infection. However, emerging data indicate that it should be regarded as a systemic disease for affecting multiple systems such as cardiovascular, respiratory, gastrointestinal and immune system. There is an accelerated need for detecting the laboratory tests that can aid in identifying infected people and asymptomatic carriers to control the virus transmission process. Although the clinical manifestation of COVID-19 has been widely defined, an overview of the most significant laboratory findings in patients with COVID-19 infection is still limited. Elevation was the predominate result among most of the laboratory parameters while a few decreased in value. Laboratory data have shown that most patients had a decrease in lymphocyte count, Eosinophils count and albumin level. Also, laboratory data recorded an elevation in Leukocyte, ESR, PT, D-dimer, PCT, CRP, ALT, AST, Bilirubin, Creatinine, CK, LDH, Ferritin, Troponin, Myoglobin, IL-6, IL10 and TNF. In general, the parameters had more prominent laboratory abnormalities in severe cases than with non-severe cases. It is well known that laboratory tests results play an important role and can support the early diagnosis of many diseases. This study was carried out to review the abnormalities among the laboratory tests and track the parameters that showed a frequently significant result supporting the primary detection of SARS-COV-2 infection.

scholarly journals Management of Chronic Diarrhea in Primary Care: The Gastroenterologists Advice

2021 ◽  
Author(s):  
Heinz F. Hammer
Keyword(s):  
Side Effects ◽  
Laboratory Tests ◽  
Chronic Diarrhea ◽  
Systemic Disease ◽  
Treatment Options ◽  
Gastrointestinal Diseases ◽  
Intractable Diarrhea ◽  
Electrolyte Disturbances ◽  
Infectious Origin ◽  
Bowel Movements

Background: Chronic diarrhea is defined as more than three bowel movements per day, or loose stools, or stool weight > 200 g/d for at least 4 weeks. Accompanying symptoms may include urgency, abdominal pain or cramps. Summary: A number of causes have to be considered, including inflammatory, neoplastic, malabsorptive, infective, vascular and functional gastrointestinal diseases. Other causes include food intolerances, side effects of drugs, or postsurgical conditions. Diarrhea may also be symptom of a systemic disease, like diabetes or hyperthyroidism. Special patient groups, like the very elderly and immunocompromised patients, pose special challenges. This review follows a question-answer style and addresses questions raised on the intersection of primary and secondary care. What do you mean by diarrhea? Why is it important to distinguish between acute or chronic diarrhea? How shall the patient with chronic diarrhea be approached? How can history and physical exam help? How can routine laboratory tests help in categorizing diarrhea? Which additional laboratory tests may be helpful? How to proceed in undiagnosed or intractable diarrhea? What are the treatment options in patients with chronic diarrhea? Key messages: Acute diarrhea is usually of infectious origin with the main treatment goal of preventing water and electrolyte disturbances. Chronic diarrhea is usually not of infectious origin and may be the symptom of a large number of gastrointestinal and general diseases or drug side effects. In undiagnosed or intractable diarrhea the question shall be raised whether the appropriate tests have been performed and interpreted correctly.

scholarly journals Is a Laboratory Evaluations Required in Every Case Admitting to the Pediatric Emergency Department with Epistaxis?

2021 ◽  
Author(s):  
Songul Tomar Güneysu ◽  
Okşan Güleryüz ◽  
elif ceylan ◽  
AYLA AKÇA ÇAĞLAR ◽  
Özlem çolak
Keyword(s):  
Emergency Department ◽  
Chronic Disease ◽  
Laboratory Tests ◽  
Complete Blood Count ◽  
Systemic Disease ◽  
Tertiary Hospital ◽  
Pediatric Emergency ◽  
Additional Treatment ◽  
Pediatric Emergency Department ◽  
Limiting Condition

ABSTRACT Background: Epistaxis is a mostly self-limiting condition common among children and is rarely severe. In this study, it was aimed to evaluate the incidence, demographic characteristics, causes of bleeding and treatment methods of patients who applied to the Pediatric Emergency Department (PED) with epistaxis, and to determine in which cases a laboratory test should be used. Method: Admitted to Gazi University Faculty of Medicine, PED which provides trauma care and is a tertiary hospital, between January 1, 2019 and December 31, 2019, 452 patients aged 0-18 years who presented with epistaxis to any reason or secondary to systemic disease were analyzed retrospectively. Results: The annual incidence was found 1.23%. The median age was 63 months, 258 of the cases (57.1%) were male. It was found that the cases most frequently applied to the hospital in the autumn months (37.6%). Sixty of the patients (13.3%) had a chronic disease and 54 (11.9%) had a history of drug use. Bleeding time was less than 5 minutes in 75.2% and 84.4% of the bleeding was unilateral. Nasal bleeding is local in 73.4%; 4.7% of them developed due to systemic reasons. The most common cause of epistaxis; while they were trauma at the first 10 years of age, they were idiopathic causes after the age of 10 years. In 434 (96%) of the patients, epistaxis spontaneously stopped and there was no need for additional treatment. Conclusion: As a result of this study, it was concluded that laboratory tests should be performed in cases with chronic disease history, bilateral bleeding, active bleeding and nontraumatic epistaxis. The situation that causes epistaxis in the childhood age group should be determined with a good history and physical examination, laboratory tests should not be used in every patient. Key Words: pediatric emergency, epistaxis, laboratory examinations, complete blood count

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