A practitioner's guide to understanding infectious disease diagnostics in the United Kingdom. Part 2: Serological diagnostic testing methods and diagnostic test result interpretation

Author(s):  
F. M. Whitlock ◽  
J. R. Newton
2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ellen Dunbar-Lavoie

Canada’s Chief Public Health Officer, Dr. Theresa Tam (BMBS (UK), FRCPC) attended medical school in the United Kingdom before immigrating to Canada where she trained in pediatrics and specialized in infectious disease. She has maintained a ‘pourquoi pas’ attitude throughout her career that has helped her realize her vocation in public health, gain experience in the healthcare field—both around the globe and on Canadian soil—and advance into prominent leadership positions. Today, as Canada’s Chief Public Health Officer, known colloquially as Canada’s Top Doctor, Dr. Tam has been thrust into the spotlight as a result of the COVID-19 pandemic. This article outlines her exciting career trajectory and explores the challenges she faces while informing Canadians of guidelines for staying healthy during the pandemic.


2019 ◽  
Vol 58 (1) ◽  
Author(s):  
Lauren M. Petersen ◽  
Isabella W. Martin ◽  
Wayne E. Moschetti ◽  
Colleen M. Kershaw ◽  
Gregory J. Tsongalis

ABSTRACT Metagenomic sequencing for infectious disease diagnostics is an important tool that holds promise for use in the clinical laboratory. Challenges for implementation so far include high cost, the length of time to results, and the need for technical and bioinformatics expertise. However, the recent technological innovation of nanopore sequencing from Oxford Nanopore Technologies (ONT) has the potential to address these challenges. ONT sequencing is an attractive platform for clinical laboratories to adopt due to its low cost, rapid turnaround time, and user-friendly bioinformatics pipelines. However, this method still faces the problem of base-calling accuracy compared to other platforms. This review highlights the general challenges of pathogen detection in clinical specimens by metagenomic sequencing, the advantages and disadvantages of the ONT platform, and how research to date supports the potential future use of nanopore sequencing in infectious disease diagnostics.


2018 ◽  
Vol 119 (2) ◽  
pp. 1456-1518 ◽  
Author(s):  
Christine F. Markwalter ◽  
Andrew G. Kantor ◽  
Carson P. Moore ◽  
Kelly A. Richardson ◽  
David W. Wright

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Roshanthi Eranga Karunaratne ◽  
Lahiru A. Wijenayaka ◽  
Sandya Sulochana Wijesundera ◽  
K. M. Nalin De Silva ◽  
Chamila Priyangani Adikaram ◽  
...  

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