Tissue‐engineered skin substitutes

2021 ◽  
Author(s):  
K. Marchant ◽  
D. A. Hendrickson
Keyword(s):  
Skin Substitutes ◽  
Engineered Skin Substitutes

scholarly journals Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries

2016 ◽  
Vol 5 (1) ◽  
pp. 320-329 ◽  
Author(s):  
Danielle Larouche ◽  
Laurence Cantin-Warren ◽  
Maxime Desgagné ◽  
Rina Guignard ◽  
Israël Martel ◽  
...  
Keyword(s):  
Full Thickness ◽  
Skin Substitutes ◽  
Skin Injuries ◽  
Full Thickness Skin ◽  
Thickness Skin ◽  
Engineered Skin Substitutes ◽  
Improved Methods

scholarly journals Invasive Techniques in Scar Management: Skin Substitutes

2020 ◽  
pp. 317-323
Author(s):  
F. W. Timmermans ◽  
E. Middelkoop
Keyword(s):  
Wound Healing ◽  
Scar Formation ◽  
Wound Management ◽  
Skin Substitutes ◽  
Current State ◽  
Scar Management ◽  
Scar Quality ◽  
Engineered Skin Substitutes ◽  
Invasive Techniques

AbstractIn the last decades, skin substitutes have emerged as an important innovation in improving scar quality. They can be applied during the initial wound management but also during scar reconstruction procedures. This chapter provides an overview on the development, current state, and future of cell-seeded and tissue-engineered skin substitutes. We will discuss some of the most important varieties of skin substitutes in the context of scar formation and wound healing.

Silk fibroin–keratin based 3D scaffolds as a dermal substitute for skin tissue engineering

2015 ◽  
Vol 7 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Nandana Bhardwaj ◽  
Wan Ting Sow ◽  
Dipali Devi ◽  
Kee Woei Ng ◽  
Biman B. Mandal ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Silk Fibroin ◽  
Skin Tissue ◽  
Dermal Substitute ◽  
Skin Substitutes ◽  
3D Scaffolds ◽  
Skin Tissue Engineering ◽  
Dermal Tissue ◽  
Engineered Skin Substitutes

Development of highly vascular dermal tissue-engineered skin substitutes with appropriate mechanical properties and cellular cues is in need for significant advancement in the field of dermal reconstruction.

37 Differentiation of Merkel Cells Precedes Innervation in Engineered Skin Substitutes after Grafting

2019 ◽  
Vol 40 (Supplement_1) ◽  
pp. S28-S28
Author(s):  
D M Supp ◽  
J M Hahn ◽  
K A Combs ◽  
K L McFarland ◽  
S T Boyce
Keyword(s):  
Merkel Cells ◽  
Skin Substitutes ◽  
Engineered Skin Substitutes

scholarly journals Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes

2018 ◽  
Vol 66 (11) ◽  
pp. 813-824 ◽  
Author(s):  
Carolyne Simard-Bisson ◽  
Lorraine Andrée Parent ◽  
Véronique J. Moulin ◽  
Bernard Fruteau de Laclos
Keyword(s):  
Human Skin ◽  
Expression Profiles ◽  
Skin Barrier ◽  
Epidermal Differentiation ◽  
Skin Barrier Function ◽  
Skin Substitutes ◽  
Differentiation Markers ◽  
Normal Human Skin ◽  
Normal Human ◽  
Engineered Skin Substitutes

Lipoxygenases (LOXs) are enzymes likely to be involved in corneocyte lipid envelope formation and skin barrier function. In humans, mutations in epidermis-type lipoxygenase 3 ( eLOX-3) and 12R–lipoxygenase ( 12R-LOX) genes are associated with autosomal recessive congenital ichthyosis (ARCI), whereas deletion of these genes in mice causes epidermal defects. LOXs also represent a matter of interest in psoriasis as well as in cancer research. However, their expression as well as the exact role of these enzymes in normal human skin have not been fully described. Our goal was to characterize the expression of epidermal LOXs in both normal human skin and Tissue-Engineered Skin Substitutes (TESS) and to consider TESS as a potential model for LOX functional studies. Staining for epidermal differentiation markers and LOXs was performed, in parallel, on normal human skin and TESS. Our results showed similar expression profiles in TESS when compared with native skin for e-LOX3, 12R-LOX, 12S-lipoxygenase (12S-LOX), and 15-lipoxygenase 2 (15-LOX-2) but not for 15-lipoxygenase 1 (15-LOX-1). Because of their appropriate epidermal differentiation and LOX expression, TESS represent an alternative model for future studies on LOX function.

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