Pulp biology: 30 years of progress

G. Rex Holland; Tatiana M. Botero

doi:10.1111/etp.12064

Proceedings of the Pulp Biology and Regeneration Group Symposium 2019: Bridging Basic and Translational Research in Pulp Biology—Developing Technologies for Regenerating Vital Dental Tissues

Journal of Endodontics ◽

10.1016/j.joen.2020.06.018 ◽

2020 ◽

Vol 46 (9) ◽

pp. S1

Author(s):

Imad About

Keyword(s):

Translational Research ◽

Dental Tissues ◽

Pulp Biology

Download Full-text

Reflections and Future Visions for Pulp Biology Research

Journal of Endodontics ◽

10.1016/j.joen.2020.06.023 ◽

2020 ◽

Vol 46 (9) ◽

pp. S42-S45

Author(s):

Anthony J. Smith

Keyword(s):

Pulp Biology ◽

Biology Research ◽

Future Visions

Download Full-text

Deciphering Reparative Processes in the Inflamed Dental Pulp

Frontiers in Dental Medicine ◽

10.3389/fdmed.2021.651219 ◽

2021 ◽

Vol 2 ◽

Author(s):

Ikhlas A. El karim ◽

Paul R. Cooper ◽

Imad About ◽

Phillip L. Tomson ◽

Fionnuala T. Lundy ◽

...

Keyword(s):

Conservative Management ◽

Dental Pulp ◽

Management Strategies ◽

Treatment Strategies ◽

Diagnostic Tools ◽

Pulp Tissue ◽

Evidence Analysis ◽

Diagnostic Approaches ◽

Pulp Biology ◽

Biology Research

Research over several decades has increased our understanding of the nature of reparative and regenerative processes in the dental pulp, at both the cellular and molecular level. However, advances in scientific knowledge have not translated into novel clinical treatment strategies for caries-induced pulpitis. This narrative review explores the evidence regarding the ability of inflamed pulp tissue to heal and how this knowledge may be used therapeutically. A literature search and evidence analysis covering basic, translational and clinical pulp biology research was performed. The review focuses on (1) the regenerative and defense capabilities of the pulp during caries-induced inflammation; (2) the potential of novel biomaterials to harness the reparative and regenerative functions of the inflamed pulp; and (3) future perspectives and opportunities for conservative management of the inflamed pulp. Current conservative management strategies for pulpitis are limited by a combination of unreliable diagnostic tools and an outdated understanding of pulpal pathophysiological responses. This approach leads to the often unnecessary removal of the entire pulp. Consequently, there is a need for better diagnostic approaches and a focus on minimally-invasive treatments utilizing biologically-based regenerative materials and technologies.

Download Full-text