Abnormal functional connectivity profiles predict drug responsiveness in patients with temporal lobe epilepsy

Epilepsia ◽  
2021 ◽  
Author(s):  
Kangrun Wang ◽  
Fangfang Xie ◽  
Chaorong Liu ◽  
Langzi Tan ◽  
Jialinzi He ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Drug Responsiveness

Functional connectivity networks are disrupted in left temporal lobe epilepsy

2006 ◽  
Vol 59 (2) ◽  
pp. 335-343 ◽  
Author(s):  
Anthony B. Waites ◽  
Regula S. Briellmann ◽  
Michael M. Saling ◽  
David F. Abbott ◽  
Graeme D. Jackson
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Left Temporal Lobe

scholarly journals Thalamic Arousal Network Disturbances in Temporal Lobe Epilepsy and Improvement After Surgery

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Hernán F J González ◽  
Srijata Chakravorti ◽  
Sarah E Goodale ◽  
Kanupriya Gupta ◽  
Daniel O Claassen ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
Occipital Lobe ◽  
Visuospatial Attention ◽  
Partial Recovery ◽  
Thalamic Nuclei ◽  
Spearman's Rho ◽  
Spearman’S Rho

Abstract INTRODUCTION The effects of temporal lobe epilepsy (TLE) on subcortical arousal structures remain incompletely understood. Here we evaluate thalamic arousal network functional connectivity in TLE and examine changes after epilepsy surgery. METHODS We examined 26 adult TLE patients and 26 matched control participants and used resting-state functional magnetic resonance imaging (fMRI) to measure functional connectivity between the thalamus (entire thalamus and 19 bilateral thalamic nuclei) and both neocortex and brainstem ascending reticular activating system (ARAS) nuclei. Postoperative imaging was completed for 19 patients > 1 yr after surgery and compared to preoperative baseline. RESULTS Before surgery, TLE patients demonstrated abnormal thalamo-occipital functional connectivity, losing the normal negative fMRI correlation between the intralaminar central lateral (CL) nucleus and medial occipital lobe seen in controls (P < .001, paired t-test). Patients also had abnormal connectivity between ARAS and CL, lower ipsilateral intrathalamic connectivity, and smaller ipsilateral thalamic volume compared to controls (P < .05 for each, paired t-tests). Abnormal brainstem-thalamic connectivity was associated with impaired visuospatial attention (? = −0.50, P = .02, Spearman's rho), while lower intrathalamic connectivity and volume were related to higher frequency of consciousness-sparing seizures (P < .02, Spearman's rho). After epilepsy surgery, patients with improved seizures showed partial recovery of thalamo-occipital and brainstem-thalamic connectivity, with values more closely resembling controls (P < .01 for each, ANOVA). CONCLUSION Overall, TLE patients demonstrate impaired connectivity in thalamic arousal networks that may be involved in visuospatial attention, but these disturbances may partially recover after successful epilepsy surgery. Thalamic arousal network dysfunction may contribute to morbidity in TLE.

Real‐time effects of interictal spikes on hippocampus and amygdala functional connectivity in unilateral temporal lobe epilepsy: AnEEG‐fMRIstudy

Epilepsia ◽  
2019 ◽  
Vol 60 (2) ◽  
pp. 246-254 ◽  
Author(s):  
Xin Tong ◽  
Dongmei An ◽  
Fenglai Xiao ◽  
Du Lei ◽  
Running Niu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Real Time ◽  
Temporal Lobe ◽  
Interictal Spikes ◽  
Time Effects

Functional Connectivity MRI Asymmetries in Lateralized Temporal Lobe Epilepsy (P03.112)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P03.112-P03.112
Author(s):  
Z. Haneef ◽  
A. Lenartowicz ◽  
H. Yeh ◽  
J. Engel ◽  
J. Stern
Keyword(s):  
Functional Connectivity ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Functional Connectivity Mri
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