scholarly journals Recurrent febrile seizures alter intrahippocampal temporal coordination but do not cause spatial learning impairments

Epilepsia ◽  
2021 ◽  
Author(s):  
Michelle L. Kloc ◽  
Jennifer M. Daglian ◽  
Gregory L. Holmes ◽  
Tallie Z. Baram ◽  
Jeremy M. Barry
Keyword(s):  
Spatial Learning ◽  
Febrile Seizures ◽  
Temporal Coordination ◽  
Learning Impairments

Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mahmoud Hashemzaei ◽  
Najmeh Baratzadeh ◽  
Iraj Sharamian ◽  
Sahar Fanoudi ◽  
Mehdi Sanati ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Spatial Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Synergistic Effects ◽  
Deionized Water ◽  
Learning Deficits ◽  
Learning Impairments ◽  
Morris Water Maze Task

Abstract Objectives H-89 (a protein kinase AII [PKA II] inhibitor) impairs the spatial memory in the Morris water maze task in rats. In the present study, we aimed to study the protective effects of nicotine and O-acetyl-L-carnitine against H-89-induced spatial memory deficits. Methods Spatial memory impairment was induced by the bilateral intrahippocampal administration of 10 µM H-89 (dissolved in dimethyl sulfoxide, DMSO) to rats. The rats then received bilateral administrations of either nicotine (1 μg/μL, dissolved in saline) or O-acetyl-L-carnitine (100 μM/side, dissolved in deionized water) alone and in combination. Control groups received either saline, deionized water, or DMSO. Results The H-89-treated animals showed significant increases in the time and distance travelled to find hidden platforms, and there was also a significant decrease in the time spent in the target quadrant compared to DMSO-treated animals. Nicotine and O-acetyl-L-carnitine had no significant effects on H-89-induced spatial learning impairments alone, but the bilateral intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevented H-89-induced spatial learning deficits and increased the time spent in the target quadrant in comparison with H-89-treated animals. Conclusions Our results indicated the potential synergistic effects of nicotine and O-acetyl-L-carnitine in preventing protein kinase AII inhibitor (H-89)-induced spatial learning impairments.

Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats

2008 ◽  
Vol 448 (1) ◽  
pp. 110-114 ◽  
Author(s):  
Chun-Ai Cui ◽  
Da-Qing Jin ◽  
Yoo Kyeong Hwang ◽  
Im-Soon Lee ◽  
Jae Kwan Hwang ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Learning Impairments

scholarly journals Hyperthermia-Induced Febrile Seizures Have Moderate and Transient Effects on Spatial Learning in Immature Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Nawel Yagoubi ◽  
Yosra Jomni ◽  
Mohsen Sakly
Keyword(s):  
Learning And Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Febrile Seizures ◽  
Hot Water ◽  
Spatial Learning And Memory ◽  
Transient Effects ◽  
Hyperthermia Treatment ◽  
Immature Rats

The aim of this study was to characterize a novel animal model hyperthermia-induced febrile seizure and to investigate the impacts of repetitive febrile seizures on spatial learning and memory performances in immature rats.Methods. Rats were subjected to hyperthermia exposure one, two, or three times in 10-day intervals during 30 min in a water bath warmed at 45–50°C and their behaviour was monitored. Morris water maze spatial learning and memory were examined for control and treated groups. Results showed that rats subjected to 30-minute hyperthermia hot water developed rapidly myoclonic jerks and then generalized seizures. After a single hyperthermia exposure, the time for generalised tonic-clonic seizures appearance was 16.08 ± 0.60 min and it decreased gradually with repetitive exposure to reach 12.46 ± 0.39 min by the third exposure. Febrile seizures altered the spatial learning and memory abilities in Morris water maze and increased the time spent to attain the platform after one or two exposures, while after a third exposure rats exhibited the same latency compared to controls. Similar results were obtained in probe test where rats, subjected to hyperthermia for one or two episodes, spent less time in the target quadrant compared to corresponding controls. Further, when platform was moved from northwest to southwest quadrant, memory transfer test indicated that after one or two hyperthermia exposures cognitive performances were slightly altered, while after a third exposure the latency to escape increased significantly compared to untreated group. It was concluded that 30 min of hyperthermia hot water was sufficient to induce febrile seizures in immature rats and an increase of susceptibility was observed with repetitive hyperthermia exposure. Hyperthermia treatment impaired cognitive performances but the effects were mostly transient and moderate.

Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments

2007 ◽  
Vol 87 (1) ◽  
pp. 21-41 ◽  
Author(s):  
Corinna Burger ◽  
M. Cecilia López ◽  
Joyce A. Feller ◽  
Henry V. Baker ◽  
Nicholas Muzyczka ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Learning Impairments ◽  
Age Related

Tadalafil Reversed H-89 – and Scopolamine – Induced Spatial Learning Impairments in Male Rats

Drug Research ◽  
2021 ◽  
Author(s):  
Kaveh Tabrizian ◽  
Fatemeh Amelinia ◽  
Maryam Belaran ◽  
Soheil Pourheidar ◽  
Hadi Mirzaei ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Memory Function ◽  
Male Rats ◽  
Learning Deficits ◽  
Learning Impairments ◽  
Cgmp Signaling ◽  
Significant Impairment ◽  
Regulatory Effects ◽  
Camp And Cgmp ◽  
Phosphodiesterase 5

AbstractAccumulated evidence shows that the cAMP and cGMP signaling pathway plays an important role in memory function and neuronal plasticity. Phosphodiesterase 5 (PDE5) is a hopeful therapeutic target in AD (Alzheimer disease), and PDE5 inhibition may be a good therapeutic strategy for the treatment of AD. In the present study, the four-day bilateral intra-hippocampal infusion of H-89 as a protein kinase AII inhibitor (10 µM/side) and intra-peritoneal injections of tadalafil (20 mg/kg) and scopolamine (0.5 mg/kg) alone and also on combination on spatial learning in Morris water maze (MWM) were investigated. DMSO and saline were used as controls for H-89 and other mentioned drugs, respectively. Rats were trained for 4 days; each day included one block of four trials. Post- training probe trial tests were performed on day 5. Administration of H-89 and scopolamine led to a significant impairment in spatial learning compared to their related controls. But, combination of tadalafil/H-89 or tadalafil/scopolamine reversed H-89 or scopolamine- induced spatial learning deficits in MWM. Taken together, these results showed the probable regulatory effects of cGMP on cholinergic and cAMP/PKA signaling pathways in co-administrations of these mentioned drugs on spatial learning in MWM.

Differential expression of PSD proteins in age-related spatial learning impairments

2007 ◽  
Vol 28 (1) ◽  
pp. 143-155 ◽  
Author(s):  
Myriel Nyffeler ◽  
Wei-Ning Zhang ◽  
Joram Feldon ◽  
Irene Knuesel
Keyword(s):  
Differential Expression ◽  
Spatial Learning ◽  
Learning Impairments ◽  
Age Related

Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system

Neuroreport ◽  
1992 ◽  
Vol 3 (11) ◽  
pp. 1005-1008 ◽  
Author(s):  
O. G. Nilsson ◽  
G. Leanza ◽  
C. Rosenblad ◽  
D. A. Lappi ◽  
R. G. Wiley ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Cholinergic System ◽  
Learning Impairments
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