Neural recruitment by ephaptic coupling in epilepsy

Epilepsia ◽  
2021 ◽  
Author(s):  
Rajat S. Shivacharan ◽  
Chia‐Chu Chiang ◽  
Xile Wei ◽  
Muthumeenakshi Subramanian ◽  
Nicholas H. Couturier ◽  
...  
Keyword(s):  
Ephaptic Coupling

Ephaptic Coupling in Hybrid Neuronal Model

2021 ◽  
Author(s):  
Gabriel Moreno Cunha ◽  
Gilberto Corso ◽  
José Garcia Vivas Miranda ◽  
Gustavo Zampier Dos Santos Lima
Keyword(s):  
Electric Fields ◽  
Action Potentials ◽  
Population Vector ◽  
Input Stimulus ◽  
Circular Statistic ◽  
Coupling Behavior ◽  
The Impact ◽  
The Brain ◽  
Ephaptic Coupling ◽  
Phase Differences

Abstract In recent decades, there has been growing interest in the impact of electric fields generated in the brain. Transmembrane ionic currents originate electric fields in the extracellular space and are capable of affecting nearby neurons, a phenomenon called ephaptic neuronal communication. In the present work, the Quadratic Integrate-and-Trigger model (QIF-E) underwent an adjustment/improvement to include the ephaptic coupling behavior between neurons and their results are compared to the empirical results. In this way, the analysis tools are employed according to the neuronal activity regime: (i) for the subthreshold regime, the circular statistic is used to describe the phase differences between the input stimulus signal and the modeled membrane response; (ii) in the suprathreshold regime, the Population Vector and the Spike Field Coherence are employed to estimate phase preferences and the coupling intensity between the input stimulus and the Action Potentials. The results observed are i) in the subthreshold regime the values of the phase differences change with distinct frequencies of an input stimulus; ii) in the supra-threshold regime the preferential phase of Action Potentials changes for different frequencies. In addition, we explore other parameters of the model, such as noise and membrane characteristic-time, in order to understand different types of neurons and extracellular environment related to ephaptic communication. Such results are consistent with results observed in empirical experiments based on ephaptic coupling behavior. In addition, the QIF-E model allows further studies on the physiological importance of ephaptic coupling in the brain, and its simplicity can open a door to simulating ephaptic coupling in neuron networks and evaluating the impact of ephaptic communication in such scenarios.

scholarly journals Exploring the Effects of Conduction Reserve and Ephaptic Coupling in Cardiac Cells

2020 ◽  
Vol 118 (3) ◽  
pp. 494a
Author(s):  
Joyce Lin ◽  
Steven Poelzing ◽  
Sharon A. George ◽  
Amara Greer-Short ◽  
Matthew W. Kay
Keyword(s):  
Cardiac Cells ◽  
Ephaptic Coupling

Ephaptic Coupling in Cardiac Myocytes

2013 ◽  
Vol 60 (2) ◽  
pp. 576-582 ◽  
Author(s):  
Joyce Lin ◽  
James P. Keener
Keyword(s):  
Cardiac Myocytes ◽  
Ephaptic Coupling

scholarly journals Ephaptic coupling in cortical neurons

2014 ◽  
Vol 8 ◽  
Author(s):  
Anastassiou Costas ◽  
Perin Rodrigo ◽  
Markram Henry ◽  
Koch Christof
Keyword(s):  
Cortical Neurons ◽  
Ephaptic Coupling

scholarly journals The Electromagnetic Will

NeuroSci ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 291-304
Author(s):  
Johnjoe McFadden
Keyword(s):  
Field Theory ◽  
Free Will ◽  
Conscious Mind ◽  
Em Field ◽  
The Brain ◽  
Ephaptic Coupling

The conscious electromagnetic information (cemi) field theory proposes that the seat of consciousness is the brain’s electromagnetic (EM) field that integrates information from trillions of firing neurons. What we call free will is its output. The cemi theory also proposes that the brain has two streams. Most actions are initiated by the first non-conscious stream that is composed of neurons that are insulated from EM field influences. These non-conscious involuntary actions are thereby invisible to our EM field-located thoughts. The theory also proposes that voluntary actions are driven by neurons that receive EM field inputs and are thereby visible to our EM field-located thoughts. I review the extensive evidence for EM field/ephaptic coupling between neurons and the increasing evidence that EM fields in the brain are a cause of behaviour. I conclude by arguing that though this EM field-driven will is not free, in the sense of being acausal, it nevertheless corresponds to the very real experience of our conscious mind being in control of our voluntary actions. Will is not an illusion. It is our experience of control by our EM field-located mind. It is an immaterial, yet physical, will.

scholarly journals Combined Effects of Gap Junctional and Ephaptic Coupling Therapies on Conduction and Arrhythmogenesis during Ischemia/Reperfusion

2018 ◽  
Vol 114 (3) ◽  
pp. 623a ◽  
Author(s):  
Gregory S. Hoeker ◽  
Carissa C. James ◽  
Sarah H. Barrett ◽  
James W. Smyth ◽  
Steven Poelzing
Keyword(s):  
Ischemia Reperfusion ◽  
Combined Effects ◽  
Gap Junctional ◽  
Ephaptic Coupling
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