scholarly journals Postinjury weight rather than cognitive or behavioral impairment predicts development of posttraumatic epilepsy after lateral fluid‐percussion injury in rats

Epilepsia ◽  
2020 ◽  
Vol 61 (9) ◽  
pp. 2035-2052 ◽  
Author(s):  
Niina Lapinlampi ◽  
Pedro Andrade ◽  
Tomi Paananen ◽  
Elina Hämäläinen ◽  
Xavier Ekolle Ndode‐Ekane ◽  
...  
Keyword(s):  
Behavioral Impairment ◽  
Posttraumatic Epilepsy ◽  
Fluid Percussion ◽  
Fluid Percussion Injury ◽  
Lateral Fluid Percussion

Increased Hippocampal CA3 Vulnerability to Low-Level Kainic Acid following Lateral Fluid Percussion Injury

2003 ◽  
Vol 20 (5) ◽  
pp. 409-420 ◽  
Author(s):  
Elisa Roncati Zanier ◽  
Stefan M. Lee ◽  
Paul M. Vespa ◽  
Christopher C. Giza ◽  
David A. Hovda
Keyword(s):  
Kainic Acid ◽  
Low Level ◽  
Fluid Percussion ◽  
Fluid Percussion Injury ◽  
Hippocampal Ca3 ◽  
Lateral Fluid Percussion

Oxidative Stress Parameters in Different Brain Structures Following Lateral Fluid Percussion Injury in the Rat

2011 ◽  
Vol 36 (5) ◽  
pp. 913-921 ◽  
Author(s):  
Kristina Pilipović ◽  
Željko Župan ◽  
Boban Dangubić ◽  
Jasenka Mršić-Pelčić ◽  
Gordana Župan
Keyword(s):  
Oxidative Stress ◽  
Brain Structures ◽  
Oxidative Stress Parameters ◽  
Fluid Percussion ◽  
Fluid Percussion Injury ◽  
Lateral Fluid Percussion ◽  
Stress Parameters

The neuronal protective effects of local brain cooling at the craniectomy site after lateral fluid percussion injury in a rat model

2013 ◽  
Vol 185 (2) ◽  
pp. 753-762 ◽  
Author(s):  
Che-Chuan Wang ◽  
Yuan-Shen Chen ◽  
Bor-Shyh Lin ◽  
Chung-Ching Chio ◽  
Chiao-Ya Hu ◽  
...  
Keyword(s):  
Rat Model ◽  
Protective Effects ◽  
Brain Cooling ◽  
Fluid Percussion ◽  
Fluid Percussion Injury ◽  
Lateral Fluid Percussion ◽  
Local Brain

Assessment of cerebral S100B levels by proton magnetic resonance spectroscopy after lateral fluid-percussion injury in the rat

2005 ◽  
Vol 102 (6) ◽  
pp. 1115-1121 ◽  
Author(s):  
Andrea Kleindienst ◽  
Christos M. Tolias ◽  
Frank D. Corwin ◽  
Christian Müller ◽  
Anthony Marmarou ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Mr Spectroscopy ◽  
Content Type ◽  
Serum S100b ◽  
Fluid Percussion ◽  
Fluid Percussion Injury ◽  
Lateral Fluid Percussion ◽  
Fine Print

Object. After traumatic brain injury (TBI), S100B protein is released by astrocytes. Furthermore, cerebrospinal fluid (CSF) and serum S100B levels have been correlated to outcome. Given that no data exist about the temporal profile of cerebral S100B levels following TBI and their correlation to serum levels, the authors examined whether proton magnetic resonance (MR) spectroscopy is capable of measuring S100B. Methods. Results of in vitro proton MR spectroscopy experiments (2.35-tesla magnet, 25 G/cm, point-resolved spatially localized spectroscopy) revealed an S100B-specific peak at 4.5 ppm and confirmed a positive correlation between different S100B concentrations (10 nM–1 µM) and the area under the curve (AUC) for the S100B peak (r = 0.991, p < 0.001). Thereafter, proton MR spectroscopy was performed in male Sprague—Dawley rats (7 × 5 × 5—mm voxel in each hemisphere, TR 3000 msec, TE 30 msec, 256 acquisitions). Exogenously increased CSF S100B levels (∼ 200 ng/ml) through the intraventricular infusion of S100B increased the AUC of the S100B peak from 0.06 ± 0.02 to 0.44 ± 0.06 (p < 0.05), whereas serum S100B levels remained normal. Two hours after lateral fluid-percussion injury, serum S100B levels increased to 0.61 ± 0.09 ng/ml (p < 0.01) and rapidly returned to normal levels, whereas the AUC of the S100B peak increased to 0.19 ± 0.04 at 2 hours postinjury and 0.41 ± 0.07 (p < 0.05) on Day 5 postinjury. Conclusions. Proton MR spectroscopy proves a strong correlation between the AUC of the S100B peak and S100B concentrations. Following experimental TBI, serum S100B levels increased for only a very short period, whereas cerebral S100B levels were increased up to Day 5 postinjury. Given that experimental data indicate that S100B is actively released following TBI, proton MR spectroscopy may represent a new tool to identify increased cerebral S100B levels in patients after injury, thus allowing its biological function to be better understood.

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