scholarly journals Nocturnal seizures are associated with more severe hypoxemia and increased risk of postictal generalized EEG suppression

Epilepsia ◽  
2017 ◽  
Vol 58 (9) ◽  
pp. e127-e131 ◽  
Author(s):  
Véronique Latreille ◽  
Myriam Abdennadher ◽  
Barbara A. Dworetzky ◽  
Judith Ramel ◽  
David White ◽  
...  
Keyword(s):  
Severe Hypoxemia ◽  
Increased Risk ◽  
Nocturnal Seizures

scholarly journals Noninvasive ventilation vs. high-flow nasal cannula oxygen for preoxygenation before intubation in patients with obesity: a post hoc analysis of a randomized controlled trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Maeva Rodriguez ◽  
Stéphanie Ragot ◽  
Rémi Coudroy ◽  
Jean-Pierre Quenot ◽  
Philippe Vignon ◽  
...  
Keyword(s):  
Noninvasive Ventilation ◽  
Controlled Trial ◽  
High Flow ◽  
Severe Hypoxemia ◽  
Hypoxemic Respiratory Failure ◽  
Acute Hypoxemic Respiratory Failure ◽  
Randomized Controlled ◽  
Increased Risk ◽  
Post Hoc ◽  
Intubation Procedure

Abstract Background Critically ill patients with obesity may have an increased risk of difficult intubation and subsequent severe hypoxemia. We hypothesized that pre-oxygenation with noninvasive ventilation before intubation as compared with high-flow nasal cannula oxygen may decrease the risk of severe hypoxemia in patients with obesity. Methods Post hoc subgroup analysis of critically ill patients with obesity (body mass index ≥ 30 kg·m−2) from a multicenter randomized controlled trial comparing preoxygenation with noninvasive ventilation and high-flow nasal oxygen before intubation of patients with acute hypoxemic respiratory failure (PaO2/FiO2 < 300 mm Hg). The primary outcome was the occurrence of severe hypoxemia (pulse oximetry < 80%) during the intubation procedure. Results Among the 313 patients included in the original trial, 91 (29%) had obesity with a mean body mass index of 35 ± 5 kg·m−2. Patients with obesity were more likely to experience an episode of severe hypoxemia during intubation procedure than patients without obesity: 34% (31/91) vs. 22% (49/222); difference, 12%; 95% CI 1 to 23%; P = 0.03. Among patients with obesity, 40 received preoxygenation with noninvasive ventilation and 51 with high-flow nasal oxygen. Severe hypoxemia occurred in 15 patients (37%) with noninvasive ventilation and 16 patients (31%) with high-flow nasal oxygen (difference, 6%; 95% CI − 13 to 25%; P = 0.54). The lowest pulse oximetry values during intubation procedure were 87% [interquartile range, 77–93] with noninvasive ventilation and 86% [78–92] with high-flow nasal oxygen (P = 0.98). After multivariable analysis, factors independently associated with severe hypoxemia in patients with obesity were intubation difficulty scale > 5 points and respiratory primary failure as reason for admission. Conclusions Patients with obesity and acute hypoxemic respiratory failure had an increased risk of severe hypoxemia during intubation procedure as compared to patients without obesity. However, preoxygenation with noninvasive ventilation may not reduce this risk compared with high-flow nasal oxygen. Trial registration Clinical trial number: NCT02668458 (http://www.clinicaltrials.gov)

scholarly journals Reduced survival in COPD patients who received long-term oxygen therapy without meeting prescription criteria: a preliminary study

2019 ◽  
Author(s):  
François Alexandre ◽  
Alain Varray ◽  
Yannick Stéphan ◽  
Maurice Hayot ◽  
Nelly Héraud
Keyword(s):  
Mortality Risk ◽  
Oxygen Therapy ◽  
Randomized Clinical Trials ◽  
Severe Hypoxemia ◽  
Physiological Basis ◽  
Risk Of Death ◽  
Copd Patients ◽  
Increased Risk ◽  
Long Term Oxygen Therapy

AbstractBackgroundRandomized clinical trials have provided clear evidence that long-term oxygen therapy (LTOT) increases life expectancy in severely hypoxemic COPD patients. However, in real-life settings, in global COPD cohorts, a paradoxical 2-3-fold increased risk of death has been reported in patients under LTOT. This discrepancy could be explained by a subgroup of patients under LTOT who do not meet the current guidelines and for whom LTOT would be associated with poor prognosis. This retrospective study of a global COPD cohort therefore sought to: (1) determine if a subgroup of patients under LTOT without severe hypoxemia could be distinguished, and (2) compare the mortality risk according to hypoxemia severity and LTOT prescription.MethodThe sample was taken from a database (NCT02055885) on 191 stable COPD patients (age: 65.1±9.8 years, 85 women) admitted for a pulmonary rehabilitation program between 2009 and 2012 and followed until 1 January 2018. Uni- and multivariate Cox proportional hazard ratio (HR) models were used to examine the associations between clinical characteristics (age, sex, blood gases, etc.), LTOT according to PaO2 level, and mortality.ResultsForty patients (21%) were under LTOT at PR entry despite not meeting the O2 prescription criteria. Patients under LTOT had a nearly 2-fold higher mortality risk adjusted by covariates (HRmultivariate=1.83; p=0.009). Furthermore, the higher mortality risk under LTOT was specific to the patients under LTOT without severe hypoxemia (HRmultivariate=2.39; p=0.04).ConclusionThe association between LTOT and mortality might be attributed to a subgroup under LTOT despite not/no longer meeting the LTOT criteria. Further studies are needed to identify the physiological basis of this phenomenon.

Factors independently associated with increased risk of pain development after ophthalmic surgery

2004 ◽  
Vol 21 (2) ◽  
pp. 101-106
Author(s):  
D. Henzler ◽  
R. Kramer ◽  
U. H. Steinhorst ◽  
S. Piepenbrock ◽  
R. Rossaint ◽  
...  
Keyword(s):  
Ophthalmic Surgery ◽  
Increased Risk

Screening colonory in asymptomatic increased risk subjects: Preliminary results

2001 ◽  
Vol 120 (5) ◽  
pp. A602-A602
Author(s):  
A PEZZOLI ◽  
V MATARESE ◽  
B PAOLA ◽  
R MICHELE ◽  
G SUSANNA ◽  
...  
Keyword(s):  
Preliminary Results ◽  
Increased Risk

1507: Acute Urinary Retention is Associated with an Increased Risk of Mortality

2007 ◽  
Vol 177 (4S) ◽  
pp. 497-497
Author(s):  
James Armitage ◽  
Nokuthaba Sibanda ◽  
Paul Cathcart ◽  
Mark Emberton ◽  
Jan Van Der Meulen
Keyword(s):  
Urinary Retention ◽  
Acute Urinary Retention ◽  
Risk Of Mortality ◽  
Increased Risk

598: Increased Risk of Newly Diagnosed Comorbidities in Prostate Cancer Patients Treated with Androgen Deprivation Therapy

2007 ◽  
Vol 177 (4S) ◽  
pp. 200-200 ◽  
Author(s):  
Andrea Gallina ◽  
Pierre I. Karakiewicz ◽  
Jochen Walz ◽  
Claudio Jeldres ◽  
Quoc-Dien Trinh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Newly Diagnosed ◽  
Increased Risk
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