scholarly journals Posterior cortex epilepsy surgery in childhood and adolescence: Predictors of long-term seizure outcome

Epilepsia ◽  
2017 ◽  
Vol 58 (3) ◽  
pp. 412-419 ◽  
Author(s):  
Georgia Ramantani ◽  
Angeliki Stathi ◽  
Armin Brandt ◽  
Karl Strobl ◽  
Susanne Schubert-Bast ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
Seizure Outcome ◽  
Childhood And Adolescence ◽  
Posterior Cortex

scholarly journals Pediatric Epilepsy Surgery

2017 ◽  
Vol 32 (5) ◽  
pp. 467-474 ◽  
Author(s):  
Krista J. Qualmann ◽  
Christine G. Spaeth ◽  
Melanie F. Myers ◽  
Paul S. Horn ◽  
Katherine Holland ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
General Population ◽  
Epilepsy Surgery ◽  
Pediatric Epilepsy ◽  
Seizure Outcome ◽  
Cognitive Disability ◽  
Pediatric Epilepsy Surgery ◽  
Surgery Outcomes

Central nervous system comorbidities have been identified in patients with epilepsy. Several of these comorbidities have been correlated with poor surgery outcomes in patient cohorts. The authors sought to determine if prevalence of comorbidities in pediatric epilepsy surgery patients and their families correlate with long-term seizure outcome in a cross-sectional analysis. Three-generation pedigrees were elicited to compare family history of epilepsy, ADHD, anxiety, autism, bipolar disorder, cognitive disability, depression, migraine, and motor disability to surgery outcomes in 52 patients. Proportions of affected patients and relatives were compared to general population comorbidity rates and the patients’ most recent seizure outcome classification. Patients and families had significantly higher rates of comorbidities than the general population. Poorer long-term seizure outcomes following resective surgery were associated with autism or cognitive disability in patients. Together these data support evidence for a common pathophysiological mechanism between epilepsy and central nervous system comorbidities.

scholarly journals Long-term seizure outcome and risk factors for recurrence after extratemporal epilepsy surgery

Epilepsia ◽  
2012 ◽  
Vol 53 (6) ◽  
pp. 970-978 ◽  
Author(s):  
Anne M. McIntosh ◽  
Clare A. Averill ◽  
Renate M. Kalnins ◽  
L. Anne Mitchell ◽  
Gavin C. A. Fabinyi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Epilepsy Surgery ◽  
Seizure Outcome ◽  
Risk Factors For Recurrence

scholarly journals Long-term seizure outcome and its predictors in patients with recurrent seizures during the first year aftertemporal lobe resective epilepsy surgery

Epilepsia ◽  
2011 ◽  
Vol 52 (5) ◽  
pp. 917-924 ◽  
Author(s):  
Kallakatta N. Ramesha ◽  
Tomin Mooney ◽  
P. Sankara Sarma ◽  
Kurupath Radhakrishnan
Keyword(s):  
Epilepsy Surgery ◽  
First Year ◽  
Seizure Outcome

Long-term outcome of extratemporal epilepsy surgery among 154 adult patients

2008 ◽  
Vol 108 (4) ◽  
pp. 676-686 ◽  
Author(s):  
Alaa Eldin Elsharkawy ◽  
Friedrich Behne ◽  
Falk Oppel ◽  
Heinz Pannek ◽  
Reinhard Schulz ◽  
...  
Keyword(s):  
Epilepsy Surgery ◽  
Cox Regression ◽  
Adult Patients ◽  
Class I ◽  
Seizure Outcome ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Factors Associated

Object The goal of this study was to evaluate the long-term outcome of patients who underwent extratemporal epilepsy surgery and to assess preoperative prognostic factors associated with seizure outcome. Methods This retrospective study included 154 consecutive adult patients who underwent epilepsy surgery at Bethel Epilepsy Centre, Bielefeld, Germany between 1991 and 2001. Seizure outcome was categorized based on the modified Engel classification. Survival statistics were calculated using Kaplan–Meier curves, life tables, and Cox regression models to evaluate the risk factors associated with outcomes. Results Sixty-one patients (39.6%) underwent frontal resections, 68 (44.1%) had posterior cortex resections, 15 (9.7%) multilobar resections, 6 (3.9%) parietal resections, and 4 (2.6%) occipital resections. The probability of an Engel Class I outcome for the overall patient group was 55.8% (95% confidence interval [CI] 52–58% at 0.5 years), 54.5% (95% CI 50–58%) at 1 year, and 51.1% (95% CI 48–54%) at 14 years. If a patient was in Class I at 2 years postoperatively, the probability of remaining in Class I for 14 years postoperatively was 88% (95% CI 78–98%). Factors predictive of poor long-term outcome after surgery were previous surgery (p = 0.04), tonic–clonic seizures (p = 0.02), and the presence of an auditory aura (p = 0.03). Factors predictive of good long-term outcome were surgery within 5 years after onset (p = 0.015) and preoperative invasive monitoring (p = 0.002). Conclusions Extratemporal epilepsy surgery is effective according to findings on long-term follow-up. The outcome at the first 2-year follow-up visit is a reliable predictor of long-term Engel Class I postoperative outcome.

Long-term seizure outcome in patients initially seizure-free after resective epilepsy surgery

Neurology ◽  
2003 ◽  
Vol 61 (4) ◽  
pp. 445-450 ◽  
Author(s):  
H. H. Yoon ◽  
H. L. Kwon ◽  
R. H. Mattson ◽  
D. D. Spencer ◽  
S. S. Spencer
Keyword(s):  
Epilepsy Surgery ◽  
Seizure Outcome
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