scholarly journals MicroRNA-139-5p negatively regulates NR2A-containing NMDA receptor in the rat pilocarpine model and patients with temporal lobe epilepsy

Epilepsia ◽  
2016 ◽  
Vol 57 (11) ◽  
pp. 1931-1940 ◽  
Author(s):  
Walid A. Alsharafi ◽  
Bo Xiao ◽  
Jing Li
Keyword(s):  
Nmda Receptor ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pilocarpine Model

Behavioral alterations in the pilocarpine model of temporal lobe epilepsy in mice

2007 ◽  
Vol 207 (2) ◽  
pp. 329-349 ◽  
Author(s):  
Ina Gröticke ◽  
Katrin Hoffmann ◽  
Wolfgang Löscher
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Behavioral Alterations ◽  
Pilocarpine Model

Modulation Effects of α-Asarone on the GABA homeostasis in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy

2012 ◽  
Vol 9 (1) ◽  
pp. 24-32
Author(s):  
Jing-Kun Miao ◽  
Qi-Xiong Chen ◽  
Chun Li ◽  
Xiao-Wen Li ◽  
Xiao-Mei Wu ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pilocarpine Model

Spontaneous Excitatory Currents and κ-Opioid Receptor Inhibition in Dentate Gyrus Are Increased in the Rat Pilocarpine Model of Temporal Lobe Epilepsy

1997 ◽  
Vol 78 (4) ◽  
pp. 1860-1868 ◽  
Author(s):  
Michele L. Simmons ◽  
Gregory W. Terman ◽  
Charles Chavkin
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Opioid Receptor ◽  
Temporal Lobe ◽  
Mossy Fiber ◽  
Perforant Path ◽  
Mossy Fiber Sprouting ◽  
Receptor Inhibition ◽  
Excitatory Activity ◽  
Pilocarpine Model

Simmons, Michele L., Gregory W. Terman, and Charles Chavkin. Spontaneous excitatory currents and κ-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. J. Neurophysiol. 78: 1860–1868, 1997. Temporal lobe epilepsy is associated with a characteristic pattern of synaptic reorganization in the hippocampal formation, consisting of neuronal loss and aberrant growth of mossy fiber collaterals into the dentate gyrus inner molecular layer. We have used the rat pilocarpine model of temporal lobe epilepsy to study the functional consequences of mossy fiber sprouting on excitatory activity and κ-opioid receptor-mediated inhibition. Using the whole cell voltage-clamp technique, we found that abnormal excitatory activity was evident in granule cells of the dentate gyrus from pilocarpine-treated rats. The frequency of spontaneous excitatory postsynaptic currents (EPSCs) was increased greatly in cells from tissue in which significant mossy fiber sprouting had developed. In the presence of bicuculline, giant spontaneous EPSCs, with large amplitudes and long durations, were seen only in association with mossy fiber sprouting. Giant EPSCs also could be evoked by low-intensity stimulation of the perforant path. Mossy fibers release not only excitatory amino acids, but also opioid peptides. κ-Opioid receptor-mediated inhibition in normal Sprague-Dawley rats was seen only in hippocampal sections from the ventral pole. In pilocarpine-treated rats, however, kappa receptor-mediated effects were seen in both ventral and more dorsal sections. Thus in this model of temporal lobe epilepsy, several types of abnormal excitatory activity were observed, thereby supporting the idea that mossy fiber sprouting leads to recurrent excitatory connections. At the same time, inhibition of excitatory activity by κ-opioid receptors was increased, perhaps representing an endogenous anticonvulsant mechanism.

Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics

2009 ◽  
Vol 219 (1) ◽  
pp. 308-318 ◽  
Author(s):  
Jennifer J.A. Long ◽  
Bixia Shen ◽  
Tao Luo ◽  
Lee Stewart ◽  
Thomas J.A. McMurran ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
General Anesthetics ◽  
Pilocarpine Model

Alteration of NMDA receptor-mediated synaptic interactions in the lateral amygdala associated with seizure activity in a mouse model of chronic temporal lobe epilepsy

Epilepsia ◽  
2010 ◽  
Vol 51 (9) ◽  
pp. 1754-1762 ◽  
Author(s):  
Stéphanie Graebenitz ◽  
Jörg Lesting ◽  
Ludmila Sosulina ◽  
Thomas Seidenbecher ◽  
Hans-Christian Pape
Keyword(s):  
Nmda Receptor ◽  
Mouse Model ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Seizure Activity ◽  
Lateral Amygdala ◽  
Synaptic Interactions
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