scholarly journals Postencephalitic epilepsy and drug-resistant epilepsy after infectious and antibody-associated encephalitis in childhood: Clinical and etiologic risk factors

Epilepsia ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. e7-e11 ◽  
Author(s):  
Sekhar C. Pillai ◽  
Shekeeb S. Mohammad ◽  
Yael Hacohen ◽  
Esther Tantsis ◽  
Kristina Prelog ◽  
...  
Keyword(s):  
Risk Factors ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

scholarly journals Definitions and Risk Factors for Drug-Resistant Epilepsy in an Adult Cohort

2021 ◽  
Vol 12 ◽  
Author(s):  
Alyssa Denton ◽  
Lilian Thorpe ◽  
Alexandra Carter ◽  
Adriana Angarita-Fonseca ◽  
Karen Waterhouse ◽  
...  
Keyword(s):  
Risk Factors ◽  
Older Adults ◽  
Risk Factor ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Drug Resistant ◽  
Age Group ◽  
Drug Resistant Epilepsy ◽  
New Diagnosis

Background: Less than one-third of people with epilepsy will develop drug-resistant epilepsy (DRE). Establishing the prognosis of each unique epilepsy case is an important part of evaluation and treatment.Most studies on DRE prognosis have been based on a pooled, heterogeneous group, including children, adults, and older adults, in the absence of clear recognition and control of important confounders, such as age group. Furthermore, previous studies were done before the 2010 definition of DRE by the International League Against Epilepsy (ILAE), so data based on the current definitions have not been entirely elucidated. This study aimed to explore the difference between 3 definitions of DRE and clinical predictors of DRE in adults and older adults.Methods: Patients with a new diagnosis of epilepsy ascertained at a Single Seizure Clinic (SSC) in Saskatchewan, Canada were included if they had at least 1 year of follow-up. The first study outcome was the diagnosis of DRE epilepsy at follow-up using the 2010 ILAE definition. This was compared with 2 alternative definitions of DRE by Kwan and Brodie and Camfield and Camfield. Finally, risk factors were analyzed using the ILAE definition.Results: In total, 95 patients with a new diagnosis of epilepsy and a median follow-up of 24 months were included. The median age of patients at the diagnosis of epilepsy was 33 years, and 51% were men. In the cohort, 32% of patients were diagnosed with DRE by the Kwan and Brodie definition, 10% by Camfield and Camfield definition, and 15% by the ILAE definition by the end of follow-up. The only statistically significant risk factor for DRE development was the failure to respond to the first anti-seizure medication (ASM).Conclusion: There were important differences in the percentage of patients diagnosed with DRE when using 3 concurrent definitions. However, the use of the ILAE definition appeared to be the most consistent through an extended follow-up. Finally, failure to respond to the first ASM was the sole significant risk factor for DRE in the cohort after considering the age group.

Analysis of heart rate variability and risk factors for SUDEP in patients with drug-resistant epilepsy

2017 ◽  
Vol 71 ◽  
pp. 60-64 ◽  
Author(s):  
Leyla Baysal-Kirac ◽  
Nail Güven Serbest ◽  
Erdi Şahin ◽  
Hava Özlem Dede ◽  
Candan Gürses ◽  
...  
Keyword(s):  
Risk Factors ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

Risk factors for postoperative depression: A retrospective analysis of 248 subjects operated on for drug-resistant epilepsy

Epilepsia ◽  
2015 ◽  
Vol 56 (10) ◽  
pp. e149-e155 ◽  
Author(s):  
Valentina Barbieri ◽  
Francesco Cardinale ◽  
Francesca Gozzo ◽  
Veronica Pelliccia ◽  
Lino Nobili ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Analysis ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

scholarly journals P.022 Neuroimaging findings and seizure type as risk factors for adult focal drug resistant epilepsy

2016 ◽  
Vol 43 (S2) ◽  
pp. S27-S27
Author(s):  
L Hernandez-Ronquillo ◽  
P Lebony-Roy ◽  
S Buckley ◽  
J Tellez Zenteno
Keyword(s):  
Risk Factors ◽  
Focal Epilepsy ◽  
Cortical Dysplasia ◽  
Age At Diagnosis ◽  
Control Group ◽  
Drug Resistant ◽  
Inclusion Criteria ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Drug Resistant Epilepsy

Background: About 35% of patients with epilepsy may develop drug-resistant epilepsy (DRE). Identifying risk factors associated with DRE will allow us to identify earlier patients in the course of the disease. Methods: This is a case-control study nested within a cohort. Chart reviews of subjects who full fill inclusion criteria were completed. Inclusion criteria included age>18 years, focal epilepsy determined by clinical correlation and EEG. DRE was determined by ILAE criteria. Results: 149 subjects were included. Seventy had DRE (cases), and seventy-nine did not have DRE (controls). DRE group had a mean age of 41 years (SD+14.8) compared to the control group (49+17.5) (p=0.003). DRE group had a mean age at diagnosis of epilepsy of 19+15.3 compared to the control group with a mean of 33.6+21. (p=<0.001). The main risk factors identified in this study were; cortical dysplasia OR 8.67 (CI 1.04-72.3, p=0.026); mesial temporal sclerosis (MTS) (OR 2.69; CI 1.12-6.47; p=0.024); and presence of complex partial seizures (OR 2.04. Conclusions: Young age at diagnosis of focal epilepsy, diagnosis of cortical dysplasia, MTS, and presence of complex partial seizures are risk factors for DRE

scholarly journals Assessment of clinical risk factors for drug-resistant epilepsy in children and teenagers

2014 ◽  
Vol 3 ◽  
pp. 141-147
Author(s):  
Marta Kasprzyk ◽  
Waldemar Brola ◽  
Janusz Wendorff
Keyword(s):  
Risk Factors ◽  
Clinical Risk Factors ◽  
Drug Resistant ◽  
Clinical Risk ◽  
Drug Resistant Epilepsy

scholarly journals Risk factors for drug-resistant epilepsy

Medicine ◽  
2019 ◽  
Vol 98 (30) ◽  
pp. e16402 ◽  
Author(s):  
Wang Xue-Ping ◽  
Wang Hai-Jiao ◽  
Zhu Li-Na ◽  
Da Xu ◽  
Liu Ling
Keyword(s):  
Risk Factors ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

scholarly journals P.009 Characterizing drug-resistant epilepsy in an adult cohort with new-onset epilepsy

2019 ◽  
Vol 46 (s1) ◽  
pp. S16
Author(s):  
A Denton ◽  
L Hernandez-Ronquillo ◽  
J Tellez-Zenteno ◽  
K Waterhouse
Keyword(s):  
Risk Factors ◽  
Age Of Onset ◽  
Significant Risk ◽  
Bivariate Analysis ◽  
Drug Resistant ◽  
Seizure Onset ◽  
Cranial Trauma ◽  
Drug Resistant Epilepsy ◽  
New Onset

Background: There are few studies exploring rates of drug resistant epilepsy in populations with new-onset epilepsy (NOE). This prospective cohort study characterizes the development of drug-resistant epilepsy (DRE) and risk factors in an adult cohort with NOE or newly-diagnosed epilepsy (NDE). Methods: Patients are from the Single Seizure Clinic (SSC) in Saskatoon, SK between 2011 and 2018. The SSC sees patients who experience their first seizure; approximately 30% are diagnosed with epilepsy. Patients were followed prospectively. We identified the following variables in the cohort: epilepsy type, seizure onset, etiology, syndromes, and rates of DRE. Inclusion criteria included patients with NO and NDE, at least 18 years at diagnosis, and a minimum 1 year of follow-up. Results: Ninety-five patients were included, 46 females and 49 males. Median age of onset was 33 years. Of those, 28.4% developed DRE. Average time between onset and DRE diagnosis was 1.44 years. Bivariate analysis identified age, gender, and cranial trauma as significant risk factors for DRE. The multivariate model was not significant. Conclusions: Our study shows that patients with new-onset epilepsy have are less likely to develop DRE compared with patients from epilepsy clinics. This study contributes valuable information about NO epilepsy in adults and the development of DRE.

scholarly journals Genetic factors and the risk of drug-resistant epilepsy in young children with epilepsy and neurodevelopment disability: A Prospective Study and Updated Meta-Analysis

2020 ◽  
Author(s):  
Chien-Hen Lin ◽  
I-Ching Chou ◽  
Syuan-Yu Hong
Keyword(s):  
Risk Factors ◽  
Genetic Factors ◽  
Meta Analysis ◽  
Genetic Defect ◽  
Genetic Group ◽  
Seizure Outcome ◽  
Drug Resistant ◽  
Pooled Prevalence ◽  
Drug Resistant Epilepsy ◽  
A Prospective Study

Abstract Background Drug-resistant epilepsy (DRE) affects 7–20% of children with epilepsy. Although some risk factors for DRE have been identified, the results have not been consistent. Moreover, data regarding the risk factors for epilepsy and its seizure outcome in the first 2 years of life are limited. Methods We analyzed data for children aged 0–2 years with epilepsy and neurodevelopmental disability (NDD) from January, 2013, through December, 2017. These patients were followed up to compared the risk of DRE in patients with genetic defect (genetic group) with that without genetic defect (nongenetic group). Additionally, we conducted a meta-analysis to identify the pooled prevalence of genetic factors in children with DRE Results A total of 96 patients were enrolled. A total of 68 patients were enrolled in the nongenetic group, whereas 28 patients were enrolled in the genetic group. The overall DRE risk in the genetic group was 6.5 times (95% confidence interval [CI], 2.15–19.6; p = 0.03) higher than that in the nongenetic group. Separately, a total of 1308 DRE patients were participated in the meta-analysis. The pooled prevalence of these patients with genetic factors was 22.8% (95% CI 17.4–29.3) Conclusions The genetic defect plays a crucial role in the development of DRE in younger children with epilepsy and NDD. The results can serve as a reference for further studies of epilepsy panel design and may also assist in the development of improved treatments and prevention strategies for DRE.

scholarly journals Evaluation of Risk Factors for Epilepsy in Pediatric Patients with Cerebral Palsy

2020 ◽  
Vol 10 (8) ◽  
pp. 481 ◽  
Author(s):  
Małgorzata Sadowska ◽  
Beata Sarecka-Hujar ◽  
Ilona Kopyta
Keyword(s):  
Risk Factors ◽  
Cerebral Palsy ◽  
Cesarean Section ◽  
Pediatric Patients ◽  
Drug Resistant ◽  
Motor Disability ◽  
Developmental Age ◽  
Neonatal Convulsions ◽  
Maternal Hypertension ◽  
Drug Resistant Epilepsy

Cerebral palsy (CP) is a set of etiologically diverse symptoms that change with the child’s age. It is one of the most frequent causes of motor disability in children. CP occurs at a frequency of 1.5 to 3.0 per 1000 live-born children. CP often coexists with epilepsy, which is drug-resistant in a high number of cases. The aim of the present study was to analyze the associations between preconception, prenatal, perinatal, neonatal, and infancy risk factors for epilepsy in a group of pediatric patients with CP. We retrospectively analyzed 181 children with CP (aged 4–17 years at diagnosis), hospitalized at the Department of Pediatrics and Developmental Age Neurology in Katowice in the years 2008–2016. Division into particular types of CP was based on Ingram’s classification. Data were analyzed using STATISTICA 13.0 (STATSOFT; Statistica, Tulsa, OK, USA). Epilepsy was diagnosed in 102 children (56.35%), of whom 44 (43%) had drug-resistant epilepsy; only in 15 cases (14.71%) was epilepsy susceptible to treatment. The incidence of epilepsy varied between the types of CP. It occurred significantly more often in children with tetraplegia (75%), ataxic form (83%), and mixed form (80%) in comparison to diplegia (32%) and hemiplegia (38%). Maternal hypertension was found to be a risk factor for epilepsy in CP patients (OR = 12.46, p < 0.001) as well as for drug-resistant epilepsy (the odds ratio (OR) = 9.86, p = 0.040). Delivery by cesarean section increased the risk of epilepsy in the CP patients over two-fold (OR = 2.17, p = 0.012). We observed also that neonatal convulsions significantly increased the risk for epilepsy (OR = 3.04, p = 0.011) as well as drug-resistant epilepsy (OR = 4.02, p = 0.002). In conclusion, maternal hypertension, neonatal convulsions, and delivery by cesarean section were the most important factors increasing the risk of epilepsy as well as drug-resistant epilepsy in the analyzed group of patients with CP.

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