scholarly journals Alterations in regional homogeneity of resting-state brain activity in mesial temporal lobe epilepsy

Epilepsia ◽  
2013 ◽  
Vol 54 (4) ◽  
pp. 658-666 ◽  
Author(s):  
Hongwu Zeng ◽  
Ricardo Pizarro ◽  
Veena A. Nair ◽  
Christian La ◽  
Vivek Prabhakaran
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Resting State ◽  
Brain Activity ◽  
Mesial Temporal Lobe Epilepsy ◽  
Regional Homogeneity ◽  
Mesial Temporal Lobe

scholarly journals Specific Resting-State Brain Networks in Mesial Temporal Lobe Epilepsy

2014 ◽  
Vol 5 ◽  
Author(s):  
Mona Maneshi ◽  
Shahabeddin Vahdat ◽  
Firas Fahoum ◽  
Christophe Grova ◽  
Jean Gotman
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Resting State ◽  
Brain Networks ◽  
Mesial Temporal Lobe Epilepsy ◽  
Mesial Temporal Lobe

scholarly journals Decreased Intrinsic Neural Timescales in Mesial Temporal Lobe Epilepsy

2021 ◽  
Vol 15 ◽  
Author(s):  
Kefan Wang ◽  
Xiaonan Zhang ◽  
Chengru Song ◽  
Keran Ma ◽  
Man Bai ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Resting State ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Mesial Temporal Lobe Epilepsy ◽  
Fmri Data ◽  
Healthy Controls ◽  
Neural Signals ◽  
Mesial Temporal Lobe ◽  
The Brain

It is well established that epilepsy is characterized by the destruction of the information capacity of brain network and the interference with information processing in regions outside the epileptogenic focus. However, the potential mechanism remains poorly understood. In the current study, we applied a recently proposed approach on the basis of resting-state fMRI data to measure altered local neural dynamics in mesial temporal lobe epilepsy (mTLE), which represents how long neural information is stored in a local brain area and reflect an ability of information integration. Using resting-state-fMRI data recorded from 36 subjects with mTLE and 36 healthy controls, we calculated the intrinsic neural timescales (INT) of neural signals by summing the positive magnitude of the autocorrelation of the resting-state brain activity. Compared to healthy controls, the INT values were significantly lower in patients in the right orbitofrontal cortices, right insula, and right posterior lobe of cerebellum. Whereas, we observed no statistically significant changes between patients with long- and short-term epilepsy duration or between left-mTLE and right-mTLE. Our study provides distinct insight into the brain abnormalities of mTLE from the perspective of the dynamics of the brain activity, highlighting the significant role of intrinsic timescale in understanding neurophysiological mechanisms. And we postulate that altered intrinsic timescales of neural signals in specific cortical brain areas may be the neurodynamic basis of cognitive impairment and emotional comorbidities in mTLE patients.

scholarly journals Hubs disruption in mesial temporal lobe epilepsy. A resting‐state fMRI study on a language‐and‐memory network

2019 ◽  
Vol 41 (3) ◽  
pp. 779-796 ◽  
Author(s):  
Elise Roger ◽  
Cedric Pichat ◽  
Laurent Torlay ◽  
Olivier David ◽  
Felix Renard ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Resting State ◽  
Resting State Fmri ◽  
Mesial Temporal Lobe Epilepsy ◽  
Fmri Study ◽  
Memory Network ◽  
Mesial Temporal Lobe
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