The effect of polygenic risk on white matter microstructural degeneration in Parkinson’s disease: a longitudinal Diffusion Tensor Imaging study

2021 ◽  
Author(s):  
Luyan Gu ◽  
Xiaojun Guan ◽  
Ting Gao ◽  
Cheng Zhou ◽  
Wenyi Yang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Longitudinal Diffusion ◽  
Polygenic Risk ◽  
Diffusion Tensor Imaging Study

Aberrant nigral diffusion in Parkinson's disease: A longitudinal diffusion tensor imaging study

2016 ◽  
Vol 31 (7) ◽  
pp. 1020-1026 ◽  
Author(s):  
Clare Loane ◽  
Marios Politis ◽  
Zinovia Kefalopoulou ◽  
Natalie Valle-Guzman ◽  
Gesine Paul ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Longitudinal Diffusion ◽  
Diffusion Tensor Imaging Study

scholarly journals Memory training impacts short-term changes in aging white matter: A Longitudinal Diffusion Tensor Imaging Study

2011 ◽  
Vol 33 (10) ◽  
pp. 2390-2406 ◽  
Author(s):  
Andreas Engvig ◽  
Anders M. Fjell ◽  
Lars T. Westlye ◽  
Torgeir Moberget ◽  
Øyvind Sundseth ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Memory Training ◽  
Short Term ◽  
Longitudinal Diffusion ◽  
Diffusion Tensor Imaging Study

scholarly journals Risperidone-induced topological alterations of anatomical brain network in first-episode drug-naive schizophrenia patients: a longitudinal diffusion tensor imaging study

2016 ◽  
Vol 46 (12) ◽  
pp. 2549-2560 ◽  
Author(s):  
M. Hu ◽  
X. Zong ◽  
J. Zheng ◽  
J. J. Mann ◽  
Z. Li ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Negative Symptoms ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
First Episode ◽  
Longitudinal Diffusion ◽  
Before And After ◽  
Drug Naïve ◽  
Diffusion Tensor Imaging Study

BackgroundIt remains unclear whether the topological deficits of the white matter network documented in cross-sectional studies of chronic schizophrenia patients are due to chronic illness or to other factors such as antipsychotic treatment effects. To answer this question, we evaluated the white matter network in medication-naive first-episode schizophrenia patients (FESP) before and after a course of treatment.MethodWe performed a longitudinal diffusion tensor imaging study in 42 drug-naive FESP at baseline and then after 8 weeks of risperidone monotherapy, and compared them with 38 healthy volunteers. Graph theory was utilized to calculate the topological characteristics of brain anatomical network. Patients’ clinical state was evaluated using the Positive and Negative Syndrome Scale (PANSS) before and after treatment.ResultsPretreatment, patients had relatively intact overall topological organizations, and deficient nodal topological properties primarily in prefrontal gyrus and limbic system components such as the bilateral anterior and posterior cingulate. Treatment with risperidone normalized topological parameters in the limbic system, and the enhancement positively correlated with the reduction in PANSS-positive symptoms. Prefrontal topological impairments persisted following treatment and negative symptoms did not improve.ConclusionsDuring the early phase of antipsychotic medication treatment there are region-specific alterations in white matter topological measures. Limbic white matter topological dysfunction improves with positive symptom reduction. Prefrontal deficits and negative symptoms are unresponsive to medication intervention, and prefrontal deficits are potential trait biomarkers and targets for negative symptom treatment development.

scholarly journals Callosal White Matter Microstructural Recovery in Abstinent Alcoholics: A Longitudinal Diffusion Tensor Imaging Study

2012 ◽  
Vol 36 (11) ◽  
pp. 1922-1931 ◽  
Author(s):  
Omar M. Alhassoon ◽  
Scott F. Sorg ◽  
Michael J. Taylor ◽  
Rick A. Stephan ◽  
Brian C. Schweinsburg ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Longitudinal Diffusion ◽  
Diffusion Tensor Imaging Study
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