CADASIL in Greece: mutational spectrum and clinical characteristics based on a systematic review and pooled analysis of published cases

2021 ◽  
Author(s):  
George P. Paraskevas ◽  
Maria Ioanna Stefanou ◽  
Vasilios C. Constantinides ◽  
Eleni Bakola ◽  
Maria Chondrogianni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Characteristics ◽  
Pooled Analysis ◽  
Mutational Spectrum

THE OUTCOME OF FCSEMS FOR REFRACTORY MPD STRICTURES: A SYSTEMATIC REVIEW AND POOLED ANALYSIS

2019 ◽  
Author(s):  
A Tringali ◽  
E Stasi ◽  
M Cintolo ◽  
E Forti ◽  
L Dioscoridi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pooled Analysis

COVID-19 in Healthcare Workers: A Systematic Review and Meta-Analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes

2020 ◽  
Author(s):  
Sergio Alejandro Gómez-Ochoa ◽  
Oscar H. Franco ◽  
Lyda Z. Rojas ◽  
Sandra Lucrecia Romero Guevara ◽  
Luis Eduardo Echeverría ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Meta Analysis

Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis

2021 ◽  
Author(s):  
Gerardo Petruzzi ◽  
Andrea Costantino ◽  
Armando De Virgilio ◽  
Jacopo Zocchi ◽  
Flaminia Campo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pooled Analysis ◽  
Lymphoepithelial Carcinoma ◽  
Carcinoma Of Larynx

scholarly journals Clinical features and outcomes of COVID-19 in older adults: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sunny Singhal ◽  
Pramod Kumar ◽  
Sumitabh Singh ◽  
Srishti Saha ◽  
Aparajit Ballav Dey
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Critically Ill ◽  
Clinical Features ◽  
Older Patients ◽  
Clinical Characteristics ◽  
Meta Analysis ◽  
Severe Infection ◽  
Factors Affecting ◽  
Pooled Prevalence

Abstract Background Few studies have focused on exploring the clinical characteristics and outcomes of COVID-19 in older patients. We conducted this systematic review and meta-analysis to have a better understanding of the clinical characteristics of older COVID-19 patients. Methods A systematic search of PubMed and Scopus was performed from December 2019 to May 3rd, 2020. Observational studies including older adults (age ≥ 60 years) with COVID-19 infection and reporting clinical characteristics or outcome were included. Primary outcome was assessing weighted pooled prevalence (WPP) of severity and outcomes. Secondary outcomes were clinical features including comorbidities and need of respiratory support. Result Forty-six studies with 13,624 older patients were included. Severe infection was seen in 51% (95% CI– 36-65%, I2–95%) patients while 22% (95% CI– 16-28%, I2–88%) were critically ill. Overall, 11% (95% CI– 5-21%, I2–98%) patients died. The common comorbidities were hypertension (48, 95% CI– 36-60% I2–92%), diabetes mellitus (22, 95% CI– 13-32%, I2–86%) and cardiovascular disease (19, 95% CI – 11-28%, I2–85%). Common symptoms were fever (83, 95% CI– 66-97%, I2–91%), cough (60, 95% CI– 50-70%, I2–71%) and dyspnoea (42, 95% CI– 19-67%, I2–94%). Overall, 84% (95% CI– 60-100%, I2–81%) required oxygen support and 21% (95% CI– 0-49%, I2–91%) required mechanical ventilation. Majority of studies had medium to high risk of bias and overall quality of evidence was low for all outcomes. Conclusion Approximately half of older patients with COVID-19 have severe infection, one in five are critically ill and one in ten die. More high-quality evidence is needed to study outcomes in this vulnerable patient population and factors affecting these outcomes.

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