Prevalence of acute dizziness and vertigo in cortical stroke

2021 ◽  
Author(s):  
Yuk Man Chan ◽  
Yean Wong ◽  
Noorulain Khalid ◽  
Stephen Wastling ◽  
Andreas Flores‐Martin ◽  
...  
Keyword(s):  
Cortical Stroke

Pure dysarthria due to small cortical stroke

Neurology ◽  
2004 ◽  
Vol 62 (2) ◽  
pp. 345-346 ◽  
Author(s):  
E. M. Gatto ◽  
C. U. Roca ◽  
M. C. Zurru ◽  
C. A. Rugilo ◽  
J. S. Kim
Keyword(s):  
Cortical Stroke

PS-42-1 Changes in the organisation of the corticomotor projection to the hand after sub-cortical stroke

1995 ◽  
Vol 97 (4) ◽  
pp. S191-S192 ◽  
Author(s):  
M.L. Thompson ◽  
G.W. Thickbroom ◽  
B. Laing ◽  
S. Wilson ◽  
F.L. Mastaglia
Keyword(s):  
Cortical Stroke

scholarly journals Global impairment and therapeutic restoration of visual plasticity mechanisms after a localized cortical stroke

2011 ◽  
Vol 108 (37) ◽  
pp. 15450-15455 ◽  
Author(s):  
F. Greifzu ◽  
S. Schmidt ◽  
K.-F. Schmidt ◽  
K. Kreikemeier ◽  
O. W. Witte ◽  
...  
Keyword(s):  
Visual Plasticity ◽  
Cortical Stroke

scholarly journals Unique Subtype of Microglia in Degenerative Thalamus After Cortical Stroke

Stroke ◽  
2021 ◽  
Author(s):  
Zhijuan Cao ◽  
Sean S. Harvey ◽  
Terrance Chiang ◽  
Aulden G. Foltz ◽  
Alex G. Lee ◽  
...  
Keyword(s):  
Neurodegenerative Disease ◽  
Microglial Activation ◽  
Inflammatory Responses ◽  
Left Middle Cerebral Artery ◽  
Gene Expressions ◽  
Progressive Development ◽  
Permanent Occlusion ◽  
Cortical Stroke ◽  
Polymerase Chain ◽  
Neuronal Functions

Background and Purpose: Stroke disrupts neuronal functions in both local and remotely connected regions, leading to network-wide deficits that can hinder recovery. The thalamus is particularly affected, with progressive development of neurodegeneration accompanied by inflammatory responses. However, the complexity of the involved inflammatory responses is poorly understood. Herein we investigated the spatiotemporal changes in the secondary degenerative thalamus after cortical stroke, using targeted transcriptome approach in conjunction with histology and flow cytometry. Methods: Cortical ischemic stroke was generated by permanent occlusion of the left middle cerebral artery in male C57BL6J mice. Neurodegeneration, neuroinflammatory responses, and microglial activation were examined in naive and stroke mice at from poststroke days (PD) 1 to 84, in both ipsilesional somatosensory cortex and ipsilesional thalamus. NanoString neuropathology panel (780 genes) was used to examine transcriptome changes at PD7 and PD28. Fluorescence activated cell sorting was used to collect CD11c + microglia from ipsilesional thalamus, and gene expressions were validated by quantitative real-time polymerase chain reaction. Results: Neurodegeneration in the thalamus was detected at PD7 and progressively worsened by PD28. This was accompanied by rapid microglial activation detected as early as PD1, which preceded the neurodegenerative changes. Transcriptome analysis showed higher number of differentially expressed genes in ipsilesional thalamus at PD28. Notably, neuroinflammation was the top activated pathway, and microglia was the most enriched cell type. Itgax (CD11c) was the most significantly increased gene, and its expression was highly detected in microglia. Flow-sorted CD11c + microglia from degenerative thalamus indicated molecular signatures similar to neurodegenerative disease–associated microglia; these included downregulated Tmem119 and CX3CR1 and upregulated ApoE, Axl, LpL, CSF1, and Cst7. Conclusions: Our findings demonstrate the dynamic changes of microglia after stroke and highlight the importance of investigating stroke network-wide deficits. Importantly, we report the existence of a unique subtype of microglia (CD11c + ) with neurodegenerative disease–associated microglia features in the degenerative thalamus after stroke.

scholarly journals Subcutaneous neurotrophin-3 infusion induces corticospinal neuroplasticity and improvements in dexterity and walking in elderly rats after large cortical strokes

2018 ◽  
Author(s):  
Denise Duricki ◽  
Sotiris Kakanos ◽  
Barbara Haenzi ◽  
Wayman Christina ◽  
Diana Cash ◽  
...  
Keyword(s):  
Muscle Spindles ◽  
Time Frame ◽  
Sensory Function ◽  
Subcutaneous Infusion ◽  
Delayed Treatment ◽  
Neurotrophin 3 ◽  
Cortical Stroke ◽  
High Doses ◽  
And Function ◽  
Sensorimotor Recovery

AbstractThere is an urgent need for a therapy which reverses disability after stroke when initiated in a time frame suitable for the majority of new victims. Neurotrophin-3 (NT3) is a growth factor made by muscle spindles and skin which is required for the survival, development and function of locomotor circuits involving afferents from muscle and skin that mediate proprioception and tactile sensation. We set out to determine whether subcutaneous supplementation of NT3 improves sensorimotor recovery after stroke in elderly rats. We show that one-month-long subcutaneous infusion of NT3 protein induces sensorimotor recovery after cortical stroke in elderly rats. Specifically, in a randomised, blinded pre-clinical trial, we show improved dexterity, walking and sensory function in rats following cortical ischemic stroke when treatment with NT3 is initiated 24 hours after stroke. Importantly, NT-3 was given in a clinically-feasible timeframe via this straightforward route. MRI and histology showed that recovery was not due to neuroprotection, as expected given the delayed treatment. Rather, anterograde tracing showed that corticospinal axons from the less-affected hemisphere sprouted in the spinal cord from cervical levels 2 to 8. Importantly, Phase I and II clinical trials by others show that repeated, subcutaneously administered high doses of recombinant NT-3 are safe and well tolerated in humans with other conditions. This paves the way for NT-3 as a therapy for stroke.

scholarly journals Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery

2021 ◽  
pp. 154596832110413
Author(s):  
Michel R. T. Sinke ◽  
Geralda A. F. van Tilborg ◽  
Anu E. Meerwaldt ◽  
Caroline L. van Heijningen ◽  
Annette van der Toorn ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Corticospinal Tract ◽  
Sprague Dawley ◽  
Post Stroke ◽  
Neuronal Communication ◽  
Cortical Stroke ◽  
Magnetic Resonance Imaging Mri ◽  
And Behavior ◽  
Sensorimotor Recovery

Background. Recovery of motor function after stroke appears to be related to the integrity of axonal connections in the corticospinal tract (CST) and corpus callosum, which may both be affected after cortical stroke. Objective. In the present study, we aimed to elucidate the relationship of changes in measures of the CST and transcallosal tract integrity, with the interhemispheric functional connectivity and sensorimotor performance after experimental cortical stroke. Methods. We conducted in vivo diffusion magnetic resonance imaging (MRI), resting-state functional MRI, and behavior testing in twenty-five male Sprague Dawley rats recovering from unilateral photothrombotic stroke in the sensorimotor cortex. Twenty-three healthy rats served as controls. Results. A reduction in the number of reconstructed fibers, a lower fractional anisotropy, and higher radial diffusivity in the ipsilesional but intact CST, reflected remote white matter degeneration. In contrast, transcallosal tract integrity remained preserved. Functional connectivity between the ipsi- and contralesional forelimb regions of the primary somatosensory cortex significantly reduced at week 8 post-stroke. Comparably, usage of the stroke-affected forelimb was normal at week 28, following significant initial impairment between day 1 and week 8 post-stroke. Conclusions. Our study shows that post-stroke motor recovery is possible despite degeneration in the CST and may be supported by intact neuronal communication between hemispheres.

Abstract WP252: Mechanism of Secondary Thalamic Injury Induced by Focal Cortical Stroke

Stroke ◽  
2018 ◽  
Vol 49 (Suppl_1) ◽  
Author(s):  
Gab Seok Kim ◽  
Sung-Ha Hong ◽  
Sean P. Marrelli
Keyword(s):  
Cortical Stroke
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