scholarly journals Characterization of chronic active multiple sclerosis lesions with sodium ( 23 Na) MRI – preliminary observations

2021 ◽  
Author(s):  
Philipp Eisele ◽  
Matthias Kraemer ◽  
Andreas Dabringhaus ◽  
Claudia E. Weber ◽  
Anne Ebert ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Active Multiple Sclerosis

Characterization of multiple sclerosis neuroinflammation and neurodegeneration with relaxation and diffusion basis spectrum imaging

2021 ◽  
pp. 135245852110233
Author(s):  
Irene M Vavasour ◽  
Peng Sun ◽  
Carina Graf ◽  
Jackie T Yik ◽  
Shannon H Kolind ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Specific Information ◽  
Axonal Loss ◽  
Normal Appearing White Matter ◽  
Relapsing Remitting ◽  
Tissue Changes ◽  
Spectrum Imaging ◽  
Magnetic Resonance Imaging Mri ◽  
And Diffusion

Background: Advanced magnetic resonance imaging (MRI) methods can provide more specific information about various microstructural tissue changes in multiple sclerosis (MS) brain. Quantitative measurement of T1 and T2 relaxation, and diffusion basis spectrum imaging (DBSI) yield metrics related to the pathology of neuroinflammation and neurodegeneration that occurs across the spectrum of MS. Objective: To use relaxation and DBSI MRI metrics to describe measures of neuroinflammation, myelin and axons in different MS subtypes. Methods: 103 participants (20 clinically isolated syndrome (CIS), 33 relapsing-remitting MS (RRMS), 30 secondary progressive MS and 20 primary progressive MS) underwent quantitative T1, T2, DBSI and conventional 3T MRI. Whole brain, normal-appearing white matter, lesion and corpus callosum MRI metrics were compared across MS subtypes. Results: A gradation of MRI metric values was seen from CIS to RRMS to progressive MS. RRMS demonstrated large oedema-related differences, while progressive MS had the most extensive abnormalities in myelin and axonal measures. Conclusion: Relaxation and DBSI-derived MRI measures show differences between MS subtypes related to the severity and composition of underlying tissue damage. RRMS showed oedema, demyelination and axonal loss compared with CIS. Progressive MS had even more evidence of increased oedema, demyelination and axonal loss compared with CIS and RRMS.

First-line treatment with alemtuzumab for active multiple sclerosis: A nationwide post-marketing survey in Austria

2017 ◽  
Vol 381 ◽  
pp. 796
Author(s):  
F. Otto ◽  
B. Bajer-Kornek ◽  
P. Rommer ◽  
F. Leutmezer ◽  
C. Franta-Elmer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Line Treatment ◽  
First Line ◽  
Post Marketing ◽  
First Line Treatment ◽  
Active Multiple Sclerosis

scholarly journals Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients

2017 ◽  
Vol 134 (3) ◽  
pp. 383-401 ◽  
Author(s):  
Gijsbert P. van Nierop ◽  
Marvin M. van Luijn ◽  
Samira S. Michels ◽  
Marie-Jose Melief ◽  
Malou Janssen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
White Matter ◽  
Functional Characterization ◽  
White Matter Lesions ◽  
Multiple Sclerosis Patients
Sign in / Sign up

Export Citation Format

Share Document