scholarly journals Botulinum toxin injection into the intrinsic laryngeal muscles to treat spasmodic dysphonia: A multicenter, placebo‐controlled, randomized double‐blinded parallel‐group comparison/open‐label clinical trial

2021 ◽  
Author(s):  
Masamitsu Hyodo ◽  
Asuka Nagao ◽  
Kento Asano ◽  
Masahiko Sakaguchi ◽  
Kenji Mizoguchi ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Botulinum Toxin ◽  
Botulinum Toxin Injection ◽  
Spasmodic Dysphonia ◽  
Group Comparison ◽  
Open Label ◽  
Laryngeal Muscles ◽  
Parallel Group ◽  
Double Blinded ◽  
Intrinsic Laryngeal Muscles

scholarly journals Life Threatening Delayed Complication of Botulinum Toxin Injection for Treatment of Spasmodic Dysphonia

2020 ◽  
Vol 121 (2) ◽  
pp. 114-117 ◽  
Author(s):  
Danylo Yershov ◽  
Richard Partridge
Keyword(s):  
Botulinum Toxin ◽  
Airway Obstruction ◽  
Botulinum Toxin Injection ◽  
Upper Airway ◽  
Upper Airway Obstruction ◽  
Surgical Approaches ◽  
Spasmodic Dysphonia ◽  
Delayed Presentation ◽  
Laryngeal Muscles ◽  
Delayed Complication

Spasmodic dysphonia is a primary task specific focal dystonia affecting the laryngeal muscles during speech. Most medical and surgical approaches to treatment of spasmodic dysphonia are aimed at the denervation of the laryngeal muscles to block symptom expression in the voice. The standard of care for the adductor form of spasmodic dysphonia is botulinum toxin chemodenervation. The common side effects of treatment with Botox are excessive breathiness and aspiration of fluids. We present the report of a delayed presentation of upper airway obstruction due to a complete vocal cords adduction requiring intubation ten days post Botox injection for the adductor form of spasmodic dysphonia. This presentation may be preceded by a change in voice, productive cough, shortness of breath, or odynophagia. We would recommend supportive treatment in an Intensive Care Unit and close liaison with the otolaryngology team for the management of this complication. Acute upper airway obstruction requiring tracheal intubation is a delayed complication of botulinum toxin administration in the adductor form of spasmodic dysphonia.

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