Acute ischaemic stroke in the absence of established vascular risk factors: Patient characteristics, stroke mechanism and long‐term outcome

2020 ◽  
Author(s):  
Stefania Nannoni ◽  
Ali Scherz‐Moussa Youma ◽  
Michael Amiguet ◽  
Ashraf Eskandari ◽  
Davide Strambo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischaemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Patient Characteristics ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Stroke Mechanism

scholarly journals A large number of cerebral microbleeds in CADASIL patients presenting with recurrent seizures: A case report

2019 ◽  
Author(s):  
Chumpol Anamnart ◽  
Dittapong Songsaeng ◽  
Sirisak Chanprasert
Keyword(s):  
Risk Factors ◽  
Ischaemic Stroke ◽  
Acute Ischaemic Stroke ◽  
Vascular Risk Factors ◽  
Cerebral Microbleeds ◽  
Diagnostic Study ◽  
Vascular Risk ◽  
Notch3 Gene ◽  
Study Results ◽  
The Brain

Abstract Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy associated with the NOTCH3 gene. Clinical manifestations include strokes, transient ischaemic events, psychiatric disturbances, dementia, and migraines. We report a case of a Thai man with a severe CADASIL phenotype who presented with recurrent seizures and acute ischaemic stroke and classic vascular risk factors. Case presentation: A 50-year-old man with a history of mood disorder and progressive cognitive decline for 20 years as well as well-controlled diabetes mellitus and hypertension presented with recurrent generalized seizures and acute right-sided weakness. An MRI of the brain showed acute infarction of the left pons, a large number of cerebral microbleeds throughout the brain and white matter abnormalities without classic anterior temporal lobe lesions. Molecular genetic testing identified a homozygous pathologic variant, c.1672C>T (p. Arg558Cys), in the NOTCH3 gene. The diagnosis of CADASIL was confirmed. His clinical symptoms deteriorated, and he died of tracheobronchitis with secretion obstruction. Conclusion: This case raises awareness of an uncommon cause of acute ischaemic stroke in patients with classic vascular risk factors and emphasizes the need for a complete evaluation in cases with unexpected clinical presentation or unexpected diagnostic study results.

P146 Disease progression in del (5q) MDS patients treated with lenalidomide: analysis of risk factors and long-term outcome in 44 patients

2007 ◽  
Vol 31 ◽  
pp. S120-S121
Author(s):  
A.A.N. Giagounidis ◽  
S. Haase ◽  
V. Lohrbacher ◽  
M. Heinsch ◽  
B. Schuran ◽  
...  
Keyword(s):  
Risk Factors ◽  
Disease Progression ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Predictors for the Immediate and Long-Term Outcome of Avascular Surgical Procedure

2009 ◽  
Vol 98 (3) ◽  
pp. 164-168 ◽  
Author(s):  
J. Virkkunen ◽  
M. Venermo ◽  
J. Saarinen ◽  
J. Salenius
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
High Risk ◽  
Predictive Value ◽  
Surgical Procedure ◽  
Operative Mortality ◽  
Survival Rates ◽  
Term Outcome ◽  
Long Term Outcome

Background and Aims: The ability to predict post-operative mortality reliably will be of assistance in making decisions concerning the treatment of an individual patient. The aim of this study was to test the GAS score as a predictor of post-operative mortality in vascular surgical patients. Material and Methods: A total of 157 consecutive patients who underwent an elective vascular surgical procedure were included in the study. The Cox proportional hazards model was used in analyzing the importance of various preoperative risk factors for the postoperative outcome. ASA and GAS were tested in predicting the short and long-term outcome. On the basis of the GAS cut-off value 77, patients were selected into low-risk (GAS low: GAS < 77) and high-risk (GAS high: GAS > = 77) groups, and the examined risk factors were analyzed to determine which of them had predictive value for the prognosis. Results: None of the patients in the GAS low group died, and mortality in the GAS high group was 4.8% (p = 0.03) at 30 days' follow-up. The 12-month survival rates were 98.6% and 78.6% (p = 0.0001), respectively, with the respective 5-year survival rates of 76.7% and 44.0% (p = 0.0001). The only independent risk factor for 30-day mortality was the renal risk factor (OR 20.2). The combination of all three GAS variables(chronic renal failure, cardiac disease and cerebrovascular disease), excluding age, was associated with a 100% two-year mortality. Conclusions: Mortality is low for patients with GAS<77. For the high-risk patients (GAS> = 77), due to its low predictive value for death, GAS yields limited value in clinical practice. In cases of patients with all three risk factors (renal, cardiac and cerebrovascular), vascular surgery should be considered very carefully.

scholarly journals Risk factors for the histologic discrepancy of gastric adenomatous lesions and long-term outcome

Medicine ◽  
2021 ◽  
Vol 100 (45) ◽  
pp. e27827
Author(s):  
Jong Seok Joo ◽  
Jae Ho Park ◽  
Ju Seok Kim ◽  
Sun Hyung Kang ◽  
Hee Seok Moon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Risk Factors for and Long-Term Outcome of Ifosphamide-Induced Nephrotoxicity in Children † 778

1998 ◽  
Vol 43 ◽  
pp. 135-135
Author(s):  
Ronen Loebstein ◽  
Gordana Atanackovic ◽  
Raafat Bishai ◽  
Sohail Khattak ◽  
Sylvian Baruchel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals 253 Sepsis associated New Onset Atrial Fibrillation; Risk Factors and Long-term Outcome

2020 ◽  
Vol 29 ◽  
pp. S147
Author(s):  
V. Moosavi ◽  
M. Paymard ◽  
R. Ebrahimi ◽  
T. Harvey ◽  
N. Parkes ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Onset Atrial Fibrillation ◽  
New Onset
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