Serum neurofilament light chain level as a biomarker of neurodegeneration and predictor of white‐matter abnormality progression

2020 ◽  
Vol 27 (10) ◽  
Author(s):  
J. K. Murthy ◽  
S. Das
Keyword(s):  
White Matter ◽  
Light Chain ◽  
White Matter Abnormality ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Chain Level

scholarly journals CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis

2019 ◽  
Vol 6 (6) ◽  
pp. 1134-1137 ◽  
Author(s):  
Marc Pawlitzki ◽  
Michaela Butryn ◽  
Florian Kirchner ◽  
Jacqueline Färber ◽  
Oliver Beuing ◽  
...  
Keyword(s):  
Light Chain ◽  
Cerebral Vasculitis ◽  
Axonal Damage ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Chain Level

[P2-338]: ARE NEUROFILAMENT LIGHT CHAIN AND WHITE MATTER INTEGRITY RELATED BIOMARKERS FOR FAMILIAL FRONTOTEMPORAL DEMENTIA?

2017 ◽  
Vol 13 (7S_Part_15) ◽  
pp. P751-P752 ◽  
Author(s):  
Jessica L. Panman ◽  
Emma Louise van der Ende ◽  
Lieke H.H. Meeter ◽  
Mark J.R.J. Bouts ◽  
Elise G.P. Dopper ◽  
...  
Keyword(s):  
White Matter ◽  
Frontotemporal Dementia ◽  
Light Chain ◽  
White Matter Integrity ◽  
Neurofilament Light Chain ◽  
Neurofilament Light

scholarly journals Neurofilament light chain level is a weak risk factor for the development of MS

Neurology ◽  
2016 ◽  
Vol 87 (11) ◽  
pp. 1076-1084 ◽  
Author(s):  
Georgina Arrambide ◽  
Carmen Espejo ◽  
Herena Eixarch ◽  
Luisa M. Villar ◽  
José C. Alvarez-Cermeño ◽  
...  
Keyword(s):  
Risk Factor ◽  
Light Chain ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Chain Level

scholarly journals Renal function is associated with blood neurofilament light chain level in older adults

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shoshin Akamine ◽  
Noriko Marutani ◽  
Daisuke Kanayama ◽  
Shiho Gotoh ◽  
Riki Maruyama ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Older Adults ◽  
Renal Function ◽  
Light Chain ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Precise Evaluation ◽  
Patients With Diabetes ◽  
Healthy Participants ◽  
Chain Level

AbstractNeurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r = 0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.

scholarly journals Neurofilament light chain level in traumatic brain injury

Medicine ◽  
2020 ◽  
Vol 99 (38) ◽  
pp. e22363 ◽  
Author(s):  
Wenyan Gao ◽  
Zhongshan Zhang ◽  
Xiaoling Lv ◽  
Qing Wu ◽  
Jing Yan ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Light Chain ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Chain Level
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