Plasma myeloperoxidase levels in acute brain ischaemia and high grade carotid stenosis

2020 ◽  
Vol 27 (8) ◽  
pp. 1604-1611
Author(s):  
D. Orion ◽  
P. Landenberg ◽  
Z. Itsekson‐Hayosh ◽  
Y. Schwammenthal ◽  
R. Tsabari ◽  
...  
Keyword(s):  
Carotid Stenosis ◽  
High Grade ◽  
Brain Ischaemia

Transient brain ischaemia (20 January 1978, p. 6): clarification and correction

1978 ◽  
Vol 16 (23) ◽  
pp. 92-92
Keyword(s):  
Carotid Endarterectomy ◽  
Carotid Stenosis ◽  
Brain Ischaemia

Our statement that in patients with transient brain ischaemia carotid endarterectomy reduces the risk of a subsequent stroke from 28% to 3% (based on the report by Wylie & Ehrenfeld, 1970) should have been qualified. We should have referred also to the study by W. S. Fields et al. (J. Amer. med. Ass. 1970, 211, 1993), in which 4% of the surgically treated patients with unilateral carotid stenosis and 12% of the controls had a stroke during the follow-up period of, on average, 3½ years. These results are based on a small total number of strokes and remain inconclusive. The paper by Whisnant was cited in error. The conclusion of our article is not affected.

scholarly journals The stronger one-sided relative hypoperfusion, the more pronounced ipsilateral spatial attentional bias in patients with asymptomatic carotid stenosis

2018 ◽  
Vol 40 (2) ◽  
pp. 314-327
Author(s):  
Jens Göttler ◽  
Stephan Kaczmarz ◽  
Rachel Nuttall ◽  
Vanessa Griese ◽  
Natan Napiórkowski ◽  
...  
Keyword(s):  
Carotid Stenosis ◽  
Attentional Bias ◽  
Brain Perfusion ◽  
Internal Carotid Artery Stenosis ◽  
Cerebral Hypoperfusion ◽  
High Grade ◽  
Healthy Controls ◽  
Cognitive Mechanisms ◽  
Continuous Arterial Spin Labeling ◽  
Parietal Cortices

Patients with asymptomatic, high-grade internal carotid artery stenosis often suffer from subtle cognitive impairments with unclear underlying neuro-cognitive mechanisms. Thus, we hypothesized that stenosis-related unilateral cerebral hypoperfusion leads to an ipsilateral attentional bias; 22 patients with asymptomatic, one-sided high-grade carotid stenosis and 24 age-matched healthy controls underwent pseudo-continuous arterial spin labeling to assess brain perfusion in the territory of the carotid arteries. Furthermore, a parametric assessment of attention functions was carried out on the basis of the computational Theory of Visual Attention. Both patients' perfusion and spatial attention were significantly more lateralized than those of healthy controls. Critically, both asymmetry indices were significantly correlated in patients, i.e. the stronger one-sided relative hypoperfusion, the stronger ipsilateral bias of attention. This association was specifically pronounced in parietal cortices and independent of white matter hyperintensities as a surrogate for cerebrovascular brain damage. Results provide evidence for a link between lateralized hypoperfusion and lateralized attentional weighting in asymptomatic, high-grade carotid stenosis. Data suggest that lateralized hypoperfusion with simultaneous spatial attentional bias might serve as a potential therapeutic target in one-sided carotid stenosis.

Increased variability of watershed areas in patients with high-grade carotid stenosis

2018 ◽  
Vol 60 (3) ◽  
pp. 311-323 ◽  
Author(s):  
Stephan Kaczmarz ◽  
Vanessa Griese ◽  
Christine Preibisch ◽  
Michael Kallmayer ◽  
Michael Helle ◽  
...  
Keyword(s):  
Carotid Stenosis ◽  
High Grade

Abstract WP162: Impact of Carotid Artery Remodeling by T1 weighted MR Imaging for the Assessment of Plaque Vulnerability in High-grade Carotid Stenosis

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Kenji Fukuda ◽  
Koji Iihara ◽  
Naoaki Yamada ◽  
Hatsue Ueda
Keyword(s):  
Carotid Artery ◽  
Carotid Stenosis ◽  
Average Rate ◽  
Intraplaque Hemorrhage ◽  
High Grade ◽  
Plaque Vulnerability ◽  
Rapid Acquisition ◽  
Asymptomatic Patients ◽  
Artery Remodeling ◽  
The Relationship

Background- The relationship between coronary artery remodeling and plaque vulnerability has been described on the basis of symptomatology and histology. However, the association with carotid artery remodeling has not been explored in detail. The aim of this study was to validate the relationship between carotid artery remodeling and plaque vulnerability by comparing the degree of outward remodeling calculated using 3D inversion-recovery-based T1-weighted imaging (magnetization-prepared rapid acquisition gradient-echo [MPRAGE]) with the symptomatology and histology of plaques extracted during carotid endarterectomy (CEA). Methods and Results- Sixty-one patients with high-grade carotid stenosis who underwent CEA and whose plaque could be examined were included. The average rate of stenosis as per the NASCET criteria was 79.8%. The carotid remodeling index (CRI) was determined by measuring the external cross-sectional vessel area (CSVA) of the maximum stenosis of the internal carotid artery (ICA) and dividing it by the external CSVA of the distal ICA unaffected by atherosclerosis using MPRAGE imaging. The relationship between the CRI and plaque vulnerability was evaluated on the basis of symptomatology and histology. The CRI was significantly higher in symptomatic patients than in asymptomatic patients (1.98 ± 0.26 vs. 1.68 ± 0.24, p < 0.0001). A higher CRI was positively correlated with the necrotic core area (r = 0.568, p < 0.0001) as well as significantly associated with severe intraplaque hemorrhage (p < 0.0001) and the prevalence of cap inflammation with macrophage (p = 0.03) and lymphocyte (p = 0.01) infiltration. Conclusion- These results validate the relationship between carotid artery remodeling and plaque vulnerability in high-grade carotid stenosis. MPRAGE imaging is effective to assess plaque vulnerability in terms of the CRI in addition to the signal intensity of carotid plaques.

scholarly journals Circulating Lipoprotein-associated Phospholipase A2 in High-grade Carotid Stenosis: A New Biomarker for Predicting Unstable Plaque

2012 ◽  
Vol 55 (2) ◽  
pp. 617
Author(s):  
G. Sarlon-Bartoli ◽  
A. Boudes ◽  
C. Buffat ◽  
M.A. Bartoli ◽  
M.D. Piercecchi-Marti ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Carotid Stenosis ◽  
High Grade ◽  
Unstable Plaque

Combined use of duplex imaging and magnetic resonance angiography for evaluation of patients with symptomatic ipsilateral high-grade carotid stenosis

1993 ◽  
Vol 17 (5) ◽  
pp. 832-840 ◽  
Author(s):  
David S. Sumner ◽  
William D. Turnipseed ◽  
Todd W. Kennell ◽  
Patrick A. Turski ◽  
Charles W. Acher
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Angiography ◽  
Carotid Stenosis ◽  
High Grade ◽  
Duplex Imaging ◽  
Combined Use

Detected Bruit

2016 ◽  
Author(s):  
Ji Y. Chong ◽  
Michael P. Lerario
Keyword(s):  
Risk Factor ◽  
Carotid Stenosis ◽  
Clinical Characteristics ◽  
Female Gender ◽  
Treatment Decisions ◽  
High Grade ◽  
Asymptomatic Carotid Stenosis ◽  
Asymptomatic Carotid ◽  
Patient Demographic ◽  
Risks And Benefits

Carotid stenosis is a risk factor for stroke. Revascularization of high-grade asymptomatic carotid stenosis in select patients can lower the risk of incident stroke. Endarterectomy and stenting are both associated with periprocedural risk. Risks and benefits need to be evaluated carefully before proceeding with any intervention. Certain patient demographic and clinical characteristics, such as female gender, may reduce the benefits of surgery and influence treatment decisions.

Sign in / Sign up

Export Citation Format

Share Document