Symptom clusters of subjective cognitive decline amongst cognitively normal older persons and their utilities in predicting objective cognitive performance: structural equation modelling

2019 ◽  
Vol 26 (9) ◽  
pp. 1153-1160 ◽  
Author(s):  
T. M. Liew ◽  
P. Yap ◽  
T.‐P. Ng ◽  
R. Mahendran ◽  
E.‐H. Kua ◽  
...  
2021 ◽  
Vol 13 ◽  
Author(s):  
Yi-Chia Wei ◽  
Chih-Chin Heather Hsu ◽  
Wen-Yi Huang ◽  
Yao-Liang Chen ◽  
Chemin Lin ◽  
...  

Objective: Although previous studies postulated that physical and cognitive decline codeveloped in preclinical dementia, the interconnected relationship among subjective cognitive complaints (SCCs), objective cognitive performance, and physical activity remained hazy. We investigated the mediating roles of physical activity between subjective and objective cognition. Diffusion tensor imaging (DTI) was utilized to test our hypothesis that brain white matter microstructural changes underlie the physical-cognitive decline in subjective cognitive decline (SCD).Methods: We enrolled cognitively normal older adults aged > 50 years in the Community Medicine Research Center of Keelung Chang Gung Memorial Hospital during 2017–2020. Regression models analyzed mediation effects of physical activity between subjective and objective cognition. The self-reported AD8 questionnaire assessed SCCs. The SCD group, defined by AD8 score ≥ 2, further underwent diffusion MRI scans. Those who agreed to record actigraphy also wore the SOMNOwatch™ for 72 h. Spearman's correlation coefficients evaluated the associations of diffusion indices with physical activity and cognitive performance.Results: In 95 cognitively normal older adults, the AD8 score and the Montreal Cognitive Assessment (MoCA) score were mediated partially by the metabolic equivalent of the International Physical Activity Questionnaire-Short Form (IPAQ-SF MET) and fully by the sarcopenia score SARC-F. That is, the relation between SCCs and poorer cognitive performance was mediated by physical inactivity. The DTI analysis of 31 SCD participants found that the MoCA score correlated with mean diffusivity at bilateral inferior cerebellar peduncles and the pyramids segment of right corticospinal tract [p < 0.05, false discovery rate (FDR) corrected]. The IPAQ-SF MET was associated with fractional anisotropy (FA) at the right posterior corona radiata (PCR) (p < 0.05, FDR corrected). In 15 SCD participants who completed actigraphy recording, the patterns of physical activity in terms of intradaily variability and interdaily stability highly correlated with FA of bilateral PCR and left superior corona radiata (p < 0.05, FDR corrected).Conclusions: This study addressed the role of physical activity in preclinical dementia. Physical inactivity mediated the relation between higher SCCs and poorer cognitive performance. The degeneration of specific white matter tracts underlay the co-development process of physical-cognitive decline in SCD.


2013 ◽  
Author(s):  
William Blake Erickson ◽  
James Michael Lampinen ◽  
Juliana Leding ◽  
Christopher S. Peters

ALQALAM ◽  
2007 ◽  
Vol 24 (2) ◽  
pp. 178
Author(s):  
Tata Rosita

Tujuan pokok penelitian ini adalah untuk memperoleh bukti empirik mengenai pembentukan organisasi cerdas pada lembaga pendidikan tinggi. Paradigma baru organisasi adalah keharusan untuk menyesuaikan dengan lingkungan sehingga memerlukan perubahan melalui kepemimpinan dan demokratisasi. Lebih jauh, kita ingin melihat bagaimana pengaruh organisasi cerdas terhadap sikap profesional dosen.Penelitian ini dilaksanakan dengan menggunakan metode survei penjelasan pada Perguruan Tinggi Swasta di D KI Jakarta. Data yang dikumpulkan terdiri dari data sekunder yaitu melalui penyebaran kuesioner. Teknik Analisis data menggunakan  Structural Equation Modelling (SEM) dengan pendekatan Path Analysis (Analisis Jalur).Berdasarkan analisis dan pembahasan hasil penelitian ini, maka dapat disimpulkan beberapa hal sebagai berikut: (1) Tanggung jawab pimpinan memiliki pengaruh yang sangat signifikan terhadap organisasi cerdas, (2) Iklim demokrasi memiliki pengaruh yang signifikan terhadap organisasi cerdas, (3) Tanggung jawab pimpinan tidak memiliki pengaruh yang signifikan terhadap Iklim demokrasi, dan (4) Organisasi cerdas memiliki pengaruh yang signifikan terhadap sikap profesional.


2015 ◽  
Vol 5 (2) ◽  
pp. 67
Author(s):  
Sayyida , ◽  
Bambang Hermanto ◽  
Edy Sugianto

Salah satu fungsi utama dari perpustakaan adalah pengemasan dan penyebaran informasi, bukanlah penciptaan informasi. Sehingga perpustakaan dituntut untuk memberikan layanan informasi yang lebih baik dan tepat guna. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kualitas pelayanan terhadap kepuasan dan loyalitas serta pengaruh dari kepuasan terhadap loyalitas pengunjung di perpustakaan Daerah Kabupaten Sumenep. Sampel yang diteliti sebanyak 200 orang yang terdiri dari Siswa, Mahasiswa dan Umum. Data dianalisis dengan menggunakan analisis structural equation modelling (SEM). Berdasarkan hasil analisis dapat disimpulkan bahwa semakin baik kualitas pelayanan, maka semakin meningkat kepuasan pengunjung serta pengunjung akan semakin royal terhadap perpustakaan Daerah Kabupaten Sumenep. Key Word :      Perpustakaan, Structural Equation Modelling (SEM), Kualitas Pelayanan, Kepuasan Dan Loyalitas


2018 ◽  
Vol 2 (1) ◽  
pp. 295-300
Author(s):  
Muhammad Soekarno Putra

Salah satu pemanfaatan perkembangan teknologi informasi di dunia pendidikan di perguruan tinggi swasta (PTS) yaitu dengan memanfaatkan dan mengimplementasikan sistem informasi akademik (SIA) berbasis web. Penelitian ini bertujuan untuk meneliti kontribusi teknologi dan infrastruktur (TI), desain (DS), sumber daya manusia (SD) dan budaya (BD) dalam pengembangan SIA berbasis web pada PTS di Palembang. Metode penelitian yang digunakan adalah metode kuantitatif, sedangkan teknik pengumpulan data menggunakan metode angket. Metode analisa data pada penelitian ini menggunakan Structural Equation Modelling (SEM). Populasi dalam penelitian ini adalah PTS di Palembang yang memiliki SIA berbasis web yaitu Universitas Bina Darma dan STMIK Palcomtech. Sedangkan yang dijadikan responden yaitu mahasiswa, dosen dan staff. Hasil dari penelitian menunjukkan bahwa teknologi dan infrastruktur, desain, sumber daya manusia dan budaya berkontribusi terhadap pengembangan SIA berbasis web pada PTS di Palembang.


2020 ◽  
Author(s):  
Zoe Victoria Joan Woodhead ◽  
Paul Andrew Thompson ◽  
Emma Karlsson ◽  
Dorothy Vera Margaret Bishop

A previous study we reported in this journal suggested that left and right handers may differ in their patterns of lateralisation for different language tasks. However, it had too few left handers (N=7) to reach any conclusions. For this update paper, further participants were added to the sample to create separate groups of left (N=31) and right handers (N=43). Two hypotheses were tested: 1) that lateralisation would be weaker at the group level in left than right handers; and 2) that left handers would show weaker covariance in lateralisation between tasks, supporting a two factor model.All participants performed the same protocol as in our previous paper: lateralisation was measured using functional transcranial Doppler sonography during six different language tasks, on two separate testing sessions. The results supported hypothesis 1, with significant differences in laterality between groups for four out of six tasks. For hypothesis 2, structural equation modelling showed that there was stronger evidence for a two factor model in left than right handers; furthermore, examination of the factor loadings suggested that the pattern of laterality across tasks may also differ between handedness groups. These results expand on what is known about the differences in laterality between left and right handers.


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