scholarly journals Do white matter hyperintensities mediate the association between brain iron deposition and cognitive abilities in older people?

2016 ◽  
Vol 23 (7) ◽  
pp. 1202-1209 ◽  
Author(s):  
M. Valdés Hernández ◽  
M. Allerhand ◽  
A. Glatz ◽  
L. Clayson ◽  
S. Muñoz Maniega ◽  
...  
Keyword(s):  
White Matter ◽  
Older People ◽  
Cognitive Abilities ◽  
White Matter Hyperintensities ◽  
Iron Deposition ◽  
Brain Iron ◽  
Brain Iron Deposition

scholarly journals Brain Iron Imaging Markers in the Presence of White Matter Hyperintensities

2021 ◽  
Author(s):  
Kyle D. Murray ◽  
Madalina E. Tivarus ◽  
Giovanni Schifitto ◽  
Md Nasir Uddin ◽  
Jianhui Zhong
Keyword(s):  
Monte Carlo ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
Clinical Results ◽  
Iron Deposition ◽  
Brain Iron ◽  
Tissue Iron ◽  
Pathological Model ◽  
Brain Iron Deposition

PurposeTo investigate the relationship between pathological brain iron deposition and white matter hyperintensities (WMHs) in cerebral small vessel disease (CSVD), via Monte Carlo simulations of magnetic susceptibility imaging and a novel imaging marker called the Expected Iron Coefficient (EIC).MethodsA synthetic pathological model of a different number of impenetrable spheres at random locations was employed to represent pathological iron deposition. The diffusion process was simulated with a Monte Carlo method with adjustable parameters to manipulate sphere size, distribution, and extracellular properties. Quantitative susceptibility mapping (QSM) was performed in a clinical dataset to study CSVD to derive and evaluate QSM, R2*, the iron microenvironment coefficient (IMC), and EIC in the presence of WMHs.ResultsThe simulations show that QSM signals increase in the presence of increased tissue iron, confirming that the EIC increases with pathology. Clinical results demonstrate that while QSM, R2*, and the IMC do not show differences in brain iron, the EIC does in the context of CSVD.ConclusionThe EIC is more sensitive to subtle changes in brain iron deposition caused by pathology, even when QSM, R2*, and the IMC do not.

scholarly journals Brain iron deposition in white matter hyperintensities: a 3-T MRI study

AGE ◽  
2012 ◽  
Vol 35 (5) ◽  
pp. 1927-1936 ◽  
Author(s):  
Shenqiang Yan ◽  
Jianzhong Sun ◽  
Yi Chen ◽  
Magdy Selim ◽  
Min Lou
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Iron Deposition ◽  
Brain Iron ◽  
Mri Study ◽  
Brain Iron Deposition

No evidence for increased brain iron deposition in patients with ischemic white matter disease

2016 ◽  
Vol 45 ◽  
pp. 61-63 ◽  
Author(s):  
Thomas Gattringer ◽  
Michael Khalil ◽  
Christian Langkammer ◽  
Margit Jehna ◽  
Alexander Pichler ◽  
...  
Keyword(s):  
White Matter ◽  
Iron Deposition ◽  
White Matter Disease ◽  
Brain Iron ◽  
Brain Iron Deposition
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