Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study

2015 ◽  
Vol 22 (11) ◽  
pp. 1482-1487 ◽  
Author(s):  
L. A. Zuurbier ◽  
M. A. Ikram ◽  
A. I. Luik ◽  
A. Hofman ◽  
E. J. W. Van Someren ◽  
...  
Keyword(s):  
Small Vessel Disease ◽  
Population Based ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Population Based Study ◽  
Activity Rhythms ◽  
Vessel Disease

Total Cerebral Small Vessel Disease Score and Anthropometric Indices: A Population-Based Study in Older Adults of Amerindian Ancestry

2021 ◽  
pp. 1-4
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera
Keyword(s):  
Older Adults ◽  
Small Vessel Disease ◽  
Brain Magnetic Resonance Imaging ◽  
Population Based ◽  
Cerebral Small Vessel Disease ◽  
The Body ◽  
Small Vessel ◽  
Population Based Study ◽  
Vessel Disease ◽  
Ordinal Logistic Regression Model

A total of 590 older adults of Amerindian ancestry living in rural Ecuador received anthropometric measurements and a brain magnetic resonance imaging to estimate the total cerebral small vessel disease (cSVD) score. A fully adjusted ordinal logistic regression model, with categories of the total cSVD score as the dependent variable, disclosed significant associations between the waist circumference, the waist-to-hip, and the waist-to-height ratios – but not the body mass index (BMI) – and the cSVD burden. Indices of abdominal obesity may better correlate with severity of cSVD than the BMI in Amerindians. Phenotypic characteristics of this population may account for these results.

scholarly journals P3-561: ATRIAL FIBRILLATION AND CEREBRAL SMALL VESSEL DISEASE IN OLD AGE: A POPULATION-BASED STUDY

2019 ◽  
Vol 15 ◽  
pp. P1190-P1190
Author(s):  
Mozhu Ding ◽  
Rui Wang ◽  
Gregoria Kalpouzos ◽  
Kristina Johnell ◽  
Laura Fratiglioni ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Old Age ◽  
Small Vessel Disease ◽  
Population Based ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Population Based Study ◽  
Vessel Disease

scholarly journals Disrupted Rest-Activity Rhythms and Cerebral Small Vessel Disease Pathology in Older Adults

Stroke ◽  
2021 ◽  
Author(s):  
Rosa Sommer ◽  
Lei Yu ◽  
Julie A. Schneider ◽  
David A. Bennett ◽  
Aron S. Buchman ◽  
...  
Keyword(s):  
Older Adults ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Activity Rhythms ◽  
Logistic Regression Models ◽  
Vessel Disease ◽  
Lower Amplitude ◽  
Rest Activity

Background and Purpose: The pathogenesis of cerebral small vessel disease remains incompletely understood. The relationship between circadian rhythm disturbances and histopathologic measures of cerebral small vessel disease has not been studied. We hypothesized that disrupted circadian rest-activity rhythms would be associated with a higher burden of cerebral small vessel disease pathology. Methods: We studied 561 community-dwelling older adults (mean age at death, 91.2, 27.4% male) from the Rush Memory and Aging Project. We used actigraphy to quantify several measures of 24-hour rest-activity rhythmicity, including interdaily stability, intradaily variability, and amplitude, and used ordinal logistic regression models to relate these measures to the severity of cerebral arteriolosclerosis, atherosclerosis, macroinfarcts, and microinfarcts, assessed at autopsy. Results: Lower interdaily stability was associated with a higher burden of arteriolosclerosis, higher intradaily variability was associated with a higher burden of atherosclerosis and subcortical infarcts, and lower amplitude was associated with a higher burden of arteriosclerosis, atherosclerosis and subcortical macroinfarcts. Moreover, the associations between interdaily stability and arteriolosclerosis and intradaily variability and subcortical infarcts were independent of cardiovascular risk factors, sleep fragmentation, and medical comorbidities. Conclusions: Disrupted rest-activity rhythms are associated with a greater burden of cerebral small vessel disease in older adults.

scholarly journals Prevalence and Risk Factors of Cerebral Small Vessel Disease in a Chinese Population-Based Sample

2018 ◽  
Vol 20 (2) ◽  
pp. 239-246 ◽  
Author(s):  
Fei Han ◽  
Fei-Fei Zhai ◽  
Quan Wang ◽  
Li-Xin Zhou ◽  
Jun Ni ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chinese Population ◽  
Small Vessel Disease ◽  
Population Based ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease
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