Revisiting the spectrum of lower motor neuron diseases with snake eyes appearance on magnetic resonance imaging

2014 ◽  
Vol 21 (9) ◽  
pp. 1233-1241 ◽  
Author(s):  
M.-V. Lebouteux ◽  
J. Franques ◽  
R. Guillevin ◽  
E. Delmont ◽  
T. Lenglet ◽  
...  
1990 ◽  
Vol 237 (8) ◽  
pp. 471-474 ◽  
Author(s):  
M. L. Sales Lu�s ◽  
A. Hormigo ◽  
C. Maur�cio ◽  
M. M. Alves ◽  
R. Serr�o

2012 ◽  
Vol 70 (7) ◽  
pp. 532-539 ◽  
Author(s):  
Antonio José da Rocha ◽  
Antonio Carlos Martins Maia Júnior

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects motor neurons in the cerebral cortex, brainstem, and spinal cord, brain regions in which conventional magnetic resonance imaging is often uninformative. Although the mean time from symptom onset to diagnosis is estimated to be about one year, the current criteria only prescribe magnetic resonance imaging to exclude "ALS mimic syndromes". Extensive application of non-conventional magnetic resonance imaging (MRI) to the study of ALS has improved our understanding of the in vivo pathological mechanisms involved in the disease. These modern imaging techniques have recently been added to the list of potential ALS biomarkers to aid in both diagnosis and monitoring of disease progression. This article provides a comprehensive review of the clinical applicability of the neuroimaging progress that has been made over the past two decades towards establishing suitable diagnostic tools for upper motor neuron (UMN) degeneration in ALS.


Author(s):  
Aziz Shaibani

Muscle atrophy is usually caused by interruption of axonal flow [axonal neuropathies, motor neuron diseases (MNDs), etc.]. If weakness is out of proportion to atrophy, demyelinating neuropathy should be suspected. Chronic myopathies and immobility also may cause atrophy, but no electromyography (EMG) evidence of denervation or myopathy is found. The pattern of atrophy is often helpful to localize the lesions. Atrophy of the interossi and preservation of the bulk of the thenar muscles suggest ulnar neuropathy, but atrophy of both would suggest a C8 or plexus pathology. Muscle enlargement may be due to fatty replacement, which can be confirmed by EMG and magnetic resonance imaging (MRI), or due to real muscle hypertrophy from excessive discharges (neuromyotonia).


2017 ◽  
Vol 7 (6) ◽  
pp. 727-731
Author(s):  
Lorenzo Ugga ◽  
Cinzia Coppola ◽  
Sirio Cocozza ◽  
Dario Saracino ◽  
Ferdinando Caranci ◽  
...  

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