First mutation in the nuclear localization signal sequence of spastin protein identified in a patient with hereditary spastic paraplegia

2012 ◽  
Vol 20 (1) ◽  
pp. e22-e23 ◽  
Author(s):  
A. Magariello ◽  
C. Tortorella ◽  
A. Patitucci ◽  
R. Tortelli ◽  
M. Liguori ◽  
...  
Keyword(s):  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Hereditary Spastic Paraplegia ◽  
Signal Sequence ◽  
Spastic Paraplegia ◽  
Nuclear Localization Signal Sequence ◽  
Localization Signal

scholarly journals Human Cytomegalovirus UL84 Protein Contains Two Nuclear Export Signals and Shuttles between the Nucleus and the Cytoplasm

2006 ◽  
Vol 80 (20) ◽  
pp. 10274-10280 ◽  
Author(s):  
Peter Lischka ◽  
Claudia Rauh ◽  
Regina Mueller ◽  
Thomas Stamminger
Keyword(s):  
Human Cytomegalovirus ◽  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Nuclear Export ◽  
Signal Sequence ◽  
Regulatory Protein ◽  
Nucleocytoplasmic Shuttling ◽  
Viral Dna ◽  
Nuclear Localization Signal Sequence ◽  
Localization Signal

ABSTRACT Previous studies defined pUL84 of human cytomegalovirus as an essential regulatory protein with nuclear localization that was proposed to act during initiation of viral-DNA synthesis. Recently, we demonstrated that a complex domain of 282 amino acids within pUL84 functions as a nonconventional nuclear localization signal. Sequence inspection of this domain revealed the presence of motifs with homology to leucine-rich nuclear export signals. Here, we report the identification of two functional, autonomous nuclear export signals and show that pUL84 acts as a CRM-1-dependent nucleocytoplasmic shuttling protein. This suggests an unexpected cytoplasmic role for this essential viral regulatory protein.

Nuclear localization signal sequence is required for VACM-1/CUL5-dependent regulation of cellular growth

2016 ◽  
Vol 368 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Angelica N. Willis ◽  
Shirley E. Bradley Dean ◽  
Joe A. Habbouche ◽  
Brian T. Kempers ◽  
Megan L. Ludwig ◽  
...  
Keyword(s):  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Signal Sequence ◽  
Cellular Growth ◽  
Nuclear Localization Signal Sequence ◽  
Localization Signal
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