Self‐referential processes and resting‐state connectivity in breast cancer patients before and one year after chemotherapy

2022 ◽  
Author(s):  
Joy Perrier ◽  
Gina Joue ◽  
Béatrice Desgranges ◽  
Djelila Allouache ◽  
Christelle Levy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Resting State ◽  
Breast Cancer Patients ◽  
One Year ◽  
Resting State Connectivity

Interleukin-10 Levels are Associated with Doxorubicin-Related Cardiotoxicity in Breast Cancer Patients in a One-Year Follow-Up Study

2021 ◽  
pp. 1-16
Author(s):  
Michelle Teodoro Alves ◽  
Ricardo Simões ◽  
Rodrigo Mendonça Cardoso Pestana ◽  
Angélica Navarro de Oliveira ◽  
Heloísa Helena Marques Oliveira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Interleukin 10 ◽  
Breast Cancer Patients ◽  
Follow Up Study ◽  
One Year

scholarly journals Arm lymphoedema and upper limb impairments in sentinel node-negative breast cancer patients: A one year follow-up study

The Breast ◽  
2016 ◽  
Vol 29 ◽  
pp. 102-108 ◽  
Author(s):  
An De Groef ◽  
Marijke Van Kampen ◽  
Elena Tieto ◽  
Petra Schönweger ◽  
Marie-Rose Christiaens ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Upper Limb ◽  
Breast Cancer Patients ◽  
Node Negative ◽  
Follow Up Study ◽  
Node Negative Breast Cancer ◽  
Arm Lymphoedema ◽  
One Year

scholarly journals Network-level functional connectivity alterations in chemotherapy treated breast cancer patients: a longitudinal resting state functional MRI study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yun Feng ◽  
Yun Fei Wang ◽  
Li Juan Zheng ◽  
Zhao Shi ◽  
Wei Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Functional Connectivity ◽  
Cancer Patients ◽  
Resting State ◽  
Cognitive Assessment ◽  
Breast Cancer Patients ◽  
Assessment Scores ◽  
Blood Biochemical ◽  
Treated Breast ◽  
Treated Breast Cancer

Abstract Background Previous studies have found abnormal structural and functional brain alterations in breast cancer survivors undergoing chemotherapy. However, the network-level brain changes following chemotherapy remain unknown. The purpose of this study was to investigate the dynamic changes of large-scale within- and between-network functional connectivity in chemotherapy-treated breast cancer patients. Methods Seventeen breast cancer patients were evaluated with resting state functional MRI (rs-fMRI), neuropsychological tests and blood examination before postoperative chemotherapy (t0), one week after completing chemotherapy (t1) and six months after completing chemotherapy (t2). Nineteen age- and education level-matched healthy controls (HC) were also recruited. Independent components analysis (ICA) was performed to assess network component using rs-fMRI data. The functional network changes were then correlated with cognitive assessment scores and blood biochemical indexes. Results One-way repeated measures ANOVA revealed significantly changed within-network functional connectivity in the anterior and posterior default mode network (ADMN and PDMN), left and right frontoparietal network (LFPN and RFPN), visual network and self-referential network. Post-hoc test showed that decreased within-network functional connectivity in ADMN, PDMN, LFPN, RFPN, SRN and central network one week after chemotherapy and increased six months after chemotherapy (all P < 0.05). As for the between-network functional connectivity, the PDMN- sensorimotor network connectivity showed the same tendency. Most of these within- and between-network functional connectivity changes were negatively associated with blood biochemical indexes and cognitive assessment scores (all P < 0.05). Conclusions These results indicated that chemotherapy may induce widespread abnormalities in resting state networks, which may serve as a potential biomarker of chemotherapy related cognitive impairment, providing insights for further functional recovery treatment.

Posttraumatic stress in breast cancer patients

2014 ◽  
Vol 21 (2) ◽  
pp. 43-50 ◽  
Author(s):  
Giedrė Bulotienė ◽  
Jurgita Matuizienė
Keyword(s):  
Breast Cancer ◽  
Posttraumatic Stress ◽  
Cancer Patients ◽  
Traumatic Experience ◽  
Newly Diagnosed ◽  
Breast Cancer Patients ◽  
Impact Of Event Scale ◽  
Event Scale ◽  
Early Evaluation ◽  
One Year

Background. Breast cancer diagnosis is a potential life-threatening event associated with significant distress. The present study aimed to identify the prevalence of posttraumatic stress and its association with clinical and social factors in early breast cancer patients and one year after surgery. Materials and methods. Four hundred twenty one newly diagnosed breast cancer patients completed three questionnaires: Impact of Event Scale – revised (IES-R), Beck Depression Inventory  II (BDI-II), Vrana & Lauterbach Traumatic Events Scale-Civilian (TEQ). Women were questioned before surgery and one year later. Patients were 18–80 years old resident Lithuanian women with histologically confirmed breast cancer and no history of other cancers. Additional requirements were as follows: ability to read Lithuanian and being capable of completing a questionnaire. Results. 51.5% of newly diagnosed breast cancer patients had from moderate to severe symptoms of PTSD (score average of IES-R ≥ 1.5). After one year it decreased and there were 33.5% of patients who had symptoms of PTSD. The scores of all subscales were decreased a bit as well. Immediately after statement of diagnosis, PTSD correlated with sadness, often cry and earlier traumatic experience. One year later, PTSD correlated with poor self perception, sadness and traumatic experience during this year. Pessimistic mood, lack of energy, difficulties to concentrate were significant to breast cancer patients. Conclusions. A significant number of breast cancer patients suffers from PTSD symptoms. After one year, the amount of patients suffering from PTSD decreased almost twice. Depression and traumatic experience are the predictors of PTSD. The findings show that early evaluation of psychoemotional needs of breast cancer patients is necessary and early interventions are meaningful.

Chronic adverse effects after axillary lymphadenectomy in breast cancer patients after weaker and stronger postoperative analgesia: Results of a prospective double-blind randomized study.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e23066-e23066
Author(s):  
Nikola Besic ◽  
Jaka Smrekar ◽  
Branka Strazisar
Keyword(s):  
Breast Cancer ◽  
Chronic Pain ◽  
Neuropathic Pain ◽  
Adverse Effects ◽  
Cancer Patients ◽  
Postoperative Analgesia ◽  
Randomized Study ◽  
Breast Cancer Patients ◽  
Axillary Lymphadenectomy ◽  
One Year

e23066 Background: Tramadol is commonly used for pain treatment, but it is not known if stronger postoperative analgesia has an effect on chronic adverse effects in breast cancer patients. The aim of this study was to compare the rate of chronic adverse effects after weaker and stronger postoperative analgesia. Methods: A prospective double-blind randomized study included 118 breast cancer patients receiving tramadol for pain relief after axillary lymphadenectomy from 2015 to 2018 (Study EUDRA CT: 2015-000992-28). All patients used one of two analgesic regimens for 4 weeks after lymphadenectomy. Patients with larger dose received 75/650 mg of tramadol with paracetamol every 8 hours and a group with lower dose received 37.5/325 mg of tramadol with paracetamol every 8 hours. All patients received for four weeks twice daily naproxen sodium 550 mg and once a day pantoprazole 20 mg. One year after surgery patients were evaluated for the presence of neuropathic pain, chronic pain, arm symptoms and lymphedema. The association between dose of tramadol and chronic postoperative adverse effects was evaluated using asymptotic z-test and chi-square test. Results: Neuropathic pain was more common one year in comparison to one month after lymphadenectomy (p = 0.0001). There was a trend for lower rate of neuropathic pain after stronger analgesia in comparison to weaker analgesia (p = 0.058). Chronic pain was present in 18% of patients one year after lymphadenectomy. There was no difference in rate of chronic pain after stronger and weaker postoperative analgesia. Patients had less arm symptoms after stronger analgesia than after weaker analgesia (p = 0.02). Furthermore, there was a trend for lower rate of lymphedema of forearm after stronger analgesia than after lower analgesia (p = 0.078). Conclusions: The patients who received stronger postoperative analgesia had a statistical trend for less often neuropathic pain in comparison to patients who received weaker analgesia. The patients who received stronger postoperative analgesia had less arm symptoms and better quality of life in comparison to patients who received weaker analgesia. Clinical trial information: EudraCT 2015-000992-28.

scholarly journals Preventive Effect of Cryotherapy on Persistent Chemotherapy-induced Peripheral Neuropathy After Completion of Weekly Paclitaxel Therapy for Breast Cancer

2021 ◽  
Author(s):  
Hideo Shigematsu ◽  
Yuri Kimura ◽  
Tomoko Itagaki ◽  
Daisuke Yasui
Keyword(s):  
Breast Cancer ◽  
Peripheral Neuropathy ◽  
Cancer Patients ◽  
Weekly Paclitaxel ◽  
Control Group ◽  
Lower Grade ◽  
Breast Cancer Patients ◽  
Preventive Effect ◽  
One Year ◽  
Paclitaxel Treatment

Abstract BackgroundChemotherapy-induced peripheral neuropathy (CIPN) is an important adverse event of taxane-based chemotherapy, which can persist in a substantial proportion of patients for years. Cryotherapy therapy is shown to be effective in prevention of CIPN during chemotherapy, but its protective effect on persistent CIPN has not been reported. MethodsCases enrolled in a randomized trial investigating the preventive effect of cryotherapy on weekly paclitaxel-induced CIPN in breast cancer patients (UMIN000034966) were evaluated for Functional Assessment of Cancer Therapy-Neurotoxicity (FACT-NTX) score and Patient Neurotoxicity Questionnaire (PNQ) at more than one year after completion of weekly paclitaxel. ResultsThirty-eight cases were evaluated for persistent CIPN with a median 2.3 (1.3-3.1) years after completion of weekly paclitaxel. The incidence of a significant decrease in FACT-NTX scores was numerically lower in the cryotherapy group compared with the control group (15.8% vs. 36.8%, p = 0.13). There was also a lower grade of PNQ sensory (p = 0.02) and motor (p = 0.17) in the cryotherapy group compared with the control group. ConclusionIn breast cancer patients treated with weekly paclitaxel, cryotherapy resulted in a numerical decrease in the incidence of persistent CIPN at more than one year after completion of weekly paclitaxel treatment.

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