scholarly journals Differential chronic social stress models in male and female mice

2021 ◽  
Author(s):  
Orit Furman ◽  
Michael Tsoory ◽  
Alon Chen
Keyword(s):  
Social Stress ◽  
Male And Female ◽  
Chronic Social Stress ◽  
Female Mice ◽  
Stress Models

A novel chronic social stress paradigm in female mice

2010 ◽  
Vol 57 (4-5) ◽  
pp. 415-420 ◽  
Author(s):  
M.V. Schmidt ◽  
S.H. Scharf ◽  
C. Liebl ◽  
D. Harbich ◽  
B. Mayer ◽  
...  
Keyword(s):  
Social Stress ◽  
Chronic Social Stress ◽  
Female Mice

scholarly journals History of winning and hierarchy landscape influence stress susceptibility in mice

2021 ◽  
Author(s):  
Katherine B LeClair ◽  
Kenny L Chan ◽  
Manuella P Kaster ◽  
Lyonna F Parise ◽  
Charles Joseph Burnett ◽  
...  
Keyword(s):  
Social Stress ◽  
Social Rank ◽  
High Mobility ◽  
Social Hierarchy ◽  
Social Stressors ◽  
Male And Female ◽  
Female Mice ◽  
Hierarchy Formation ◽  
History Of ◽  
Stress Susceptibility

Social hierarchy formation is strongly evolutionarily conserved. Across species, rank within social hierarchy has large effects on health and behavior. To investigate the relationship between social rank and stress susceptibility, we exposed ranked male and female mice to social and non-social stressors and manipulated social hierarchy position. We found that rank predicts same sex social stress outcomes: dominance in males and females confers resilience while subordination confers susceptibility. Pre-existing rank does not predict non-social stress outcomes in females and weakly does so in males, but rank emerging under stress conditions reveals social interaction deficits in male and female subordinates. Both history of winning and rank of cage mates affect stress susceptibility in males: rising to the top rank through high mobility confers resilience and mice that lose dominance lose stress resilience, though gaining dominance over a subordinate animal does not confer resilience. Overall, we have demonstrated a relationship between social status and stress susceptibility, particularly when taking into account individual history of winning and the overall hierarchy landscape in male and female mice.

scholarly journals Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
F. Quessy ◽  
T. Bittar ◽  
L. J. Blanchette ◽  
M. Lévesque ◽  
B. Labonté
Keyword(s):  
Molecular Interactions ◽  
Life Stress ◽  
Social Stress ◽  
Cognitive Strategies ◽  
Social Defeat ◽  
Social Defeat Stress ◽  
Male And Female ◽  
Female Mice ◽  
Males And Females ◽  
Dopaminergic Pathways

AbstractOur ability to develop the cognitive strategies required to deal with daily-life stress is regulated by region-specific neuronal networks. Experimental evidence suggests that prolonged stress in mice induces depressive-like behaviors via morphological, functional and molecular changes affecting the mesolimbic and mesocortical dopaminergic pathways. Yet, the molecular interactions underlying these changes are still poorly understood, and whether they affect males and females similarly is unknown. Here, we used chronic social defeat stress (CSDS) to induce depressive-like behaviors in male and female mice. Density of the mesolimbic and mesocortical projections was assessed via immuno-histochemistry combined with Sholl analysis along with the staining of activity-dependent markers pERK and c-fos in the ventral tegmental area (VTA), nucleus accumbens (NAc) and medial prefrontal cortex (mPFC). Our results show that social stress decreases the density of TH+ dopaminergic axonal projections in the deep layers of the mPFC in susceptible but not resilient male and female mice. Consistently, our analyses suggest that pERK expression is decreased in the mPFC but increased in the NAc following CSDS in males and females, with no change in c-fos expression in both sexes. Overall, our findings indicate that social defeat stress impacts the mesolimbic and mesocortical pathways by altering the molecular interactions regulating somatic and axonal plasticity in males and females.

scholarly journals History of winning and hierarchy landscape influence stress susceptibility in mice

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Katherine B LeClair ◽  
Kenny L Chan ◽  
Manuella P Kaster ◽  
Lyonna F Parise ◽  
Charles Joseph Burnett ◽  
...  
Keyword(s):  
Social Stress ◽  
Social Rank ◽  
High Mobility ◽  
Social Hierarchy ◽  
Social Stressors ◽  
Male And Female ◽  
Female Mice ◽  
Hierarchy Formation ◽  
History Of ◽  
Stress Susceptibility

Social hierarchy formation is strongly evolutionarily conserved. Across species, rank within social hierarchy has large effects on health and behavior. To investigate the relationship between social rank and stress susceptibility, we exposed ranked male and female mice to social and non-social stressors and manipulated social hierarchy position. We found that rank predicts same sex social stress outcomes: dominance in males and females confers resilience while subordination confers susceptibility. Pre-existing rank does not predict non-social stress outcomes in females and weakly does so in males, but rank emerging under stress conditions reveals social interaction deficits in male and female subordinates. Both history of winning and rank of cage mates affect stress susceptibility in males: rising to the top rank through high mobility confers resilience and mice that lose dominance lose stress resilience, though gaining dominance over a subordinate animal does not confer resilience. Overall, we have demonstrated a relationship between social status and stress susceptibility, particularly when taking into account individual history of winning and the overall hierarchy landscape in male and female mice.

scholarly journals Sex-specific retinal anomalies induced by chronic social stress in mice

2020 ◽  
Author(s):  
E Arsenault ◽  
AA Lavigne ◽  
S Mansouri ◽  
K Francis ◽  
TP Bittar ◽  
...  
Keyword(s):  
Stress Response ◽  
Social Stress ◽  
Social Defeat ◽  
Major Depressive ◽  
Male And Female ◽  
Retinal Activity ◽  
Female Mice ◽  
Chronic Social Defeat Stress ◽  
Before And After ◽  
The Brain

AbstractMajor depressive disorder (MDD) is one of the most common consequences of chronic stress. Still, there is currently no reliable biomarker to detect individuals at risk to develop MDD. Recently, the retina emerged as an effective way to approach the brain and investigate psychiatric disorders with the use of the electroretinogram (ERG). In this study, cones and rods ERGs were performed in male and female mice before and after chronic social defeat stress (CSDS). Mice were then divided as susceptible or resilient to stress. Significant results were only observed in rods ERGs. In males, susceptible mice showed prolonged a-wave implicit times at baseline that were shortened after CSDS. The a-wave was also decreased in both susceptible and resilient male mice after CSDS. In females, rod a-waves were shorter in susceptible than in control mice after CSDS resulting from the latter demonstrating delayed a-waves. Baseline ERGs were able to predict – to some extent – the expression of susceptibility and resilience before stress exposition in male and female mice. Overall, our findings suggest that retinal activity is a presumptive biomarker of stress response and that the ERG could potentially serve as a predicting tool of the stress response in mice.

Individual Differences in Response to Chronic Social Stress: Behavioral, Endocrine and Immune Profiles

2008 ◽  
Author(s):  
Eneritz Gomez ◽  
Amaia Arregi ◽  
Garikoitz Beitia ◽  
Oscar Vegas ◽  
Arantza Azpiroz ◽  
...  
Keyword(s):  
Individual Differences ◽  
Social Stress ◽  
Chronic Social Stress

Lasting effects of chronic social stress in mice: Impact of antidepressant treatment

2009 ◽  
Vol 42 (05) ◽  
Author(s):  
SH Scharf ◽  
V Sterlemann ◽  
C Liebl ◽  
K Ganea ◽  
P Weber ◽  
...  
Keyword(s):  
Social Stress ◽  
Antidepressant Treatment ◽  
Chronic Social Stress
Sign in / Sign up

Export Citation Format

Share Document