Disorganized resting‐state functional connectivity between the dorsal attention network and intrinsic networks in Parkinson's disease with freezing of gait

2021 ◽  
Author(s):  
Qian Yu ◽  
Qun Li ◽  
Weidong Fang ◽  
Yuchan Wang ◽  
Yingcheng Zhu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Freezing Of Gait ◽  
Resting State Functional Connectivity ◽  
Attention Network ◽  
Dorsal Attention Network

Changes in Resting-State Functional Connectivity Related to Freezing of Gait in Parkinson's Disease

Neuroscience ◽  
2019 ◽  
Vol 418 ◽  
pp. 311-317 ◽  
Author(s):  
Alexandra Potvin-Desrochers ◽  
Trina Mitchell ◽  
Thomas Gisiger ◽  
Caroline Paquette
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Freezing Of Gait ◽  
Resting State Functional Connectivity

scholarly journals Thalamic morphology predicts the onset of freezing of gait in Parkinson’s disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Nicholas D’Cruz ◽  
Griet Vervoort ◽  
Sima Chalavi ◽  
Bauke W. Dijkstra ◽  
Moran Gilat ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Resting State ◽  
Freezing Of Gait ◽  
Study Entry ◽  
Resting State Functional Connectivity ◽  
Behavioral Correlates ◽  
Local Volume ◽  
Linear Evolution ◽  
Risk Of Falls

AbstractThe onset of freezing of gait (FOG) in Parkinson’s disease (PD) is a critical milestone, marked by a higher risk of falls and reduced quality of life. FOG is associated with alterations in subcortical neural circuits, yet no study has assessed whether subcortical morphology can predict the onset of clinical FOG. In this prospective multimodal neuroimaging cohort study, we performed vertex-based analysis of grey matter morphology in fifty-seven individuals with PD at study entry and two years later. We also explored the behavioral correlates and resting-state functional connectivity related to these local volume differences. At study entry, we found that freezers (N = 12) and persons who developed FOG during the course of the study (converters) (N = 9) showed local inflations in bilateral thalamus in contrast to persons who did not (non-converters) (N = 36). Longitudinally, converters (N = 7) also showed local inflation in the left thalamus, as compared to non-converters (N = 36). A model including sex, daily levodopa equivalent dose, and local thalamic inflation predicted conversion with good accuracy (AUC: 0.87, sensitivity: 88.9%, specificity: 77.8%). Exploratory analyses showed that local thalamic inflations were associated with larger medial thalamic sub-nuclei volumes and better cognitive performance. Resting-state analyses further revealed that converters had stronger thalamo-cortical coupling with limbic and cognitive regions pre-conversion, with a marked reduction in coupling over the two years. Finally, validation using the PPMI cohort suggested FOG-specific non-linear evolution of thalamic local volume. These findings provide markers of, and deeper insights into conversion to FOG, which may foster earlier intervention and better mobility for persons with PD.

scholarly journals Resting state functional connectivity of the striatum in Parkinson’s disease

Brain ◽  
2012 ◽  
Vol 135 (12) ◽  
pp. 3699-3711 ◽  
Author(s):  
Carl D. Hacker ◽  
Joel S. Perlmutter ◽  
Susan R. Criswell ◽  
Beau M. Ances ◽  
Abraham Z. Snyder
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity

Resting-state functional connectivity of dentate nucleus is associated with tremor in Parkinson’s disease

2015 ◽  
Vol 262 (10) ◽  
pp. 2247-2256 ◽  
Author(s):  
Huizi Ma ◽  
Huimin Chen ◽  
Jinping Fang ◽  
Liyan Gao ◽  
Lingyan Ma ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Dentate Nucleus ◽  
Resting State Functional Connectivity

scholarly journals Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease

2014 ◽  
Vol 35 (11) ◽  
pp. 5431-5441 ◽  
Author(s):  
KyoungWon Baik ◽  
Jungho Cha ◽  
Jee Hyun Ham ◽  
Gwang-Min Baek ◽  
Mun Kyung Sunwoo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
De Novo ◽  
Resting State Functional Connectivity ◽  
Dopaminergic Modulation

scholarly journals Olfactory performance and resting state functional connectivity in non-demented drug naïve patients with Parkinson's disease

2014 ◽  
Vol 36 (5) ◽  
pp. 1716-1727 ◽  
Author(s):  
Mun Kyung Sunwoo ◽  
Jungho Cha ◽  
Jee Hyun Ham ◽  
Sook K. Song ◽  
Jin Yong Hong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Drug Naïve
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