Cholinergic transmission from the basal forebrain modulates social memory in male mice

2021 ◽  
Author(s):  
Ornela Kljakic ◽  
Mohammed Al‐Onaizi ◽  
Helena Janíčková ◽  
Kevin S. Chen ◽  
Monica S. Guzman ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Social Memory ◽  
Cholinergic Transmission ◽  
Male Mice

Endocrine stress responsivity and social memory in 3xTg-AD female and male mice: A tale of two experiments

2020 ◽  
Vol 126 ◽  
pp. 104852
Author(s):  
Elizabeth T. Nguyen ◽  
Din Selmanovic ◽  
Marissa Maltry ◽  
Rachel Morano ◽  
Ana Franco-Villanueva ◽  
...  
Keyword(s):  
Social Memory ◽  
Male Mice ◽  
Stress Responsivity

Interactions between the effects of basal forebrain lesions and chronic treatment with MDL 26,479 on learning and markers of cholinergic transmission

1993 ◽  
Vol 610 (2) ◽  
pp. 181-193 ◽  
Author(s):  
Lee Ann Holley ◽  
Jerry A. Miller ◽  
Paula A. Chmielewski ◽  
Paul Dudchenko ◽  
Martin Sarter
Keyword(s):  
Basal Forebrain ◽  
Chronic Treatment ◽  
Cholinergic Transmission

scholarly journals Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Joshua Obermayer ◽  
Antonio Luchicchi ◽  
Tim S. Heistek ◽  
Sybren F. de Kloet ◽  
Huub Terra ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Basal Forebrain ◽  
Pyramidal Neurons ◽  
Local Source ◽  
Cholinergic Transmission ◽  
Cortical Layers ◽  
Prefrontal Cortical ◽  
Cholinergic Synaptic Transmission ◽  
And Control ◽  
Behavioural Function

AbstractNeocortical choline acetyltransferase (ChAT)-expressing interneurons are a subclass of vasoactive intestinal peptide (ChAT-VIP) neurons of which circuit and behavioural function are unknown. Here, we show that ChAT-VIP neurons directly excite neighbouring neurons in several layers through fast synaptic transmission of acetylcholine (ACh) in rodent medial prefrontal cortex (mPFC). Both interneurons in layers (L)1–3 as well as pyramidal neurons in L2/3 and L6 receive direct inputs from ChAT-VIP neurons mediated by fast cholinergic transmission. A fraction (10–20%) of postsynaptic neurons that received cholinergic input from ChAT-VIP interneurons also received GABAergic input from these neurons. In contrast to regular VIP interneurons, ChAT-VIP neurons did not disinhibit pyramidal neurons. Finally, we show that activity of these neurons is relevant for behaviour and they control attention behaviour distinctly from basal forebrain ACh inputs. Thus, ChAT-VIP neurons are a local source of cortical ACh that directly excite neurons throughout cortical layers and contribute to attention.

scholarly journals Simplified behavioural tests for transient social memory in male mice and dams

2007 ◽  
Author(s):  
Olga Lopatina ◽  
Hong-Xiang Liu ◽  
Natalia A Shnayder ◽  
Haruhiro Higashida
Keyword(s):  
Social Memory ◽  
Male Mice ◽  
Behavioural Tests

scholarly journals Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics

2020 ◽  
Author(s):  
Csaba Vastagh ◽  
Imre Farkas ◽  
Michael M. Scott ◽  
Zsolt Liposits
Keyword(s):  
Basal Forebrain ◽  
Brain Slices ◽  
Low Frequency ◽  
Laser Pulses ◽  
Facilitatory Effect ◽  
Male Mice ◽  
Gnrh Neurons ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Patch Clamp Electrophysiology

Abstract Glucagon-like peptide-1 (GLP-1) regulates reproduction centrally, although, the neuroanatomical basis of the process is unknown. Therefore, the putative networking of the central GLP-1 and gonadotropin-releasing hormone (GnRH) systems was addressed in male mice using whole mount immunocytochemistry and optogenetics. Enhanced antibody penetration and optical clearing procedures applied to 500–1000 µm thick basal forebrain slices allowed the simultaneous visualization of the two distinct systems in the basal forebrain. Beaded GLP-1-IR axons innervated about a quarter of GnRH neurons (23.2 ± 1.4%) forming either single or multiple contacts. GnRH dendrites received a more intense GLP-1 innervation (64.6 ± 0.03%) than perikarya (35.4 ± 0.03%). The physiological significance of the innervation was examined by optogenetic activation of channelrhodopsin-2 (ChR2)-expressing axons of preproglucagon (GCG) neurons upon the firing of GnRH neurons by patch clamp electrophysiology in acute brain slices of triple transgenic mice (Gcg-cre/ChR2/GFP-GnRH). High-frequency laser beam stimulation (20 Hz, 10 ms pulse width, 3 mW laser power) of ChR2-expressing GCG axons in the mPOA increased the firing rate of GnRH neurons (by 75 ± 17.3%, p = 0.0007). Application of the GLP-1 receptor antagonist, Exendin-3-(9-39) (1 μM), prior to the photo-stimulation, abolished the facilitatory effect. In contrast, low-frequency trains of laser pulses (0.2 Hz, 60 pulses) had no effect on the spontaneous postsynaptic currents of GnRH neurons. The findings indicate a direct wiring of GLP-1 neurons with GnRH cells which route is excitatory for the GnRH system. The pathway may relay metabolic signals to GnRH neurons and synchronize metabolism with reproduction.

scholarly journals SK3-overexpression drives sex-dimorphic working and social memory impairment in mice

2020 ◽  
Author(s):  
Alline C Campos ◽  
Franciele F Scarante ◽  
Sabine Martin ◽  
Marcio Lazzarini ◽  
Doris Hermes ◽  
...  
Keyword(s):  
Social Memory ◽  
Hippocampal Formation ◽  
Memory Performance ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Estrogen Signaling ◽  
K Channel ◽  
Male Mice ◽  
Female Mice ◽  
Type 3

AbstractAlthough sex differences in memory tasks dependent on hippocampal function have been described in several species, including rodents and humans, the exact mechanisms involved remain debatable. The function of the small-conductance Ca2+-activated K+ channel type 3 has been associated with cognitive deficits, and its overexpression in male mice (T/T) induces shrinkage of the hippocampus. Here we describe that opposite to the observation in males, in female mice, SK3-induced-reduction in the volume of the hippocampal formation does not interfere with working and social memory performance. Male, but not female T/T mice showed decreased adult hippocampal neurogenesis and down-regulation of the expression of the genes related to Akt/mTOR and MAP kinase pathways. T/T male mice exhibit impaired estrogen and Neurogulin 1 signaling. An increased number of filopodia spines is observed in the dentate gyrus (DG). Our results suggest a fine-tune modulation of SK3 expression participates in the sex-dependent function of the hippocampus via estrogen signaling and neuroplasticity in the DG. Our results reinforce the importance of testing male and female mice while conducting experiments with transgenic mice.

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