scholarly journals Dopamine D1 receptor‐expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine

2021 ◽  
Author(s):  
Yukari Nakamura ◽  
Sophie Longueville ◽  
Akinori Nishi ◽  
Denis Herve ◽  
Jean‐Antoine Girault ◽  
...  
Keyword(s):  
Single Injection ◽  
Dopamine D1 Receptor ◽  
D1 Receptor

Functional MHCI deficiency induces ADHD-like symptoms with increased dopamine D1 receptor expression

2021 ◽  
Author(s):  
Hong-Rui Meng ◽  
Toshiko Suenaga ◽  
Mitsuhiro Edamura ◽  
Atsuo Fukuda ◽  
Yasushi Ishida ◽  
...  
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Expression

scholarly journals Serine mutations in transmembrane V of the dopamine D1 receptor affect ligand interactions and receptor activation.

1992 ◽  
Vol 267 (25) ◽  
pp. 17780-17786
Author(s):  
N.J. Pollock ◽  
A.M. Manelli ◽  
C.W. Hutchins ◽  
M.E. Steffey ◽  
R.G. MacKenzie ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Ligand Interactions

scholarly journals Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D1 Receptor

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3799
Author(s):  
Tim J. Fyfe ◽  
Peter J. Scammells ◽  
J. Robert Lane ◽  
Ben Capuano
Keyword(s):  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Intrinsic Activity ◽  
Optical Isomers ◽  
Allosteric Modulators ◽  
Disease States ◽  
Starting Point ◽  
Significant Difference ◽  
Optically Pure ◽  
Allosteric Properties

(1) Background: Two first-in-class racemic dopamine D1 receptor (D1R) positive allosteric modulator (PAM) chemotypes (1 and 2) were identified from a high-throughput screen. In particular, due to its selectivity for the D1R and reported lack of intrinsic activity, compound 2 shows promise as a starting point toward the development of small molecule allosteric modulators to ameliorate the cognitive deficits associated with some neuropsychiatric disease states; (2) Methods: Herein, we describe the enantioenrichment of optical isomers of 2 using chiral auxiliaries derived from (R)- and (S)-3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-one (d- and l-pantolactone, respectively); (3) Results: We confirm both the racemate and enantiomers of 2 are active and selective for the D1R, but that the respective stereoisomers show a significant difference in their affinity and magnitude of positive allosteric cooperativity with dopamine; (4) Conclusions: These data warrant further investigation of asymmetric syntheses of optically pure analogues of 2 for the development of D1R PAMs with superior allosteric properties.

Dopamine D1 receptor alleviates doxorubicin-induced cardiac injury by inhibiting NLRP3 inflammasome

2021 ◽  
Vol 561 ◽  
pp. 7-13
Author(s):  
Jiao Liu ◽  
Yuxuan Jin ◽  
Bei Wang ◽  
Yiran Wang ◽  
Shengkai Zuo ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Cardiac Injury ◽  
Dopamine D1 Receptor ◽  
D1 Receptor

In vivo andin vitro ethanol exposure in prenatal rat brain: GABAB receptor modulation on dopamine D1 receptor and protein kinase A

Synapse ◽  
2008 ◽  
Vol 62 (7) ◽  
pp. 534-543 ◽  
Author(s):  
H.Y. Lee ◽  
N. Naha ◽  
S.P. Li ◽  
M.J. Jo ◽  
M.L. Naseer ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Rat Brain ◽  
Gabab Receptor ◽  
Ethanol Exposure ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Modulation ◽  
Kinase A

Analysis of genetic variations in the dopamine D1 receptor (DRD1) gene and antipsychotics-induced tardive dyskinesia in schizophrenia

2010 ◽  
Vol 67 (4) ◽  
pp. 383-388 ◽  
Author(s):  
I-Ching Lai ◽  
Geng-Han Mo ◽  
Mao-Liang Chen ◽  
Ying-Chieh Wang ◽  
Jen-Yeu Chen ◽  
...  
Keyword(s):  
Tardive Dyskinesia ◽  
Genetic Variations ◽  
Dopamine D1 Receptor ◽  
D1 Receptor
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