Is there a single beta oscillation band interfering with movement in Parkinson’s Disease?

2021 ◽  
Author(s):  
Elena M. Belova ◽  
Ulia Semenova ◽  
Anna A. Gamaleya ◽  
Alexey A. Tomskiy ◽  
Alexey Sedov
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Oscillation

scholarly journals Characteristics of Beta Waveform Shape in Parkinson’s Disease Detected with Scalp Electroencephalography

2019 ◽  
Author(s):  
Nicko Jackson ◽  
Scott R. Cole ◽  
Bradley Voytek ◽  
Nicole C. Swann
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Phase ◽  
Beta Oscillations ◽  
Non Invasive ◽  
Scalp Eeg ◽  
Phase Amplitude ◽  
Beta Frequency ◽  
Intracranial Recordings ◽  
Beta Oscillation

AbstractNeural activity in the beta frequency range (13-30 Hz) is excessively synchronized in Parkinson’s Disease (PD). Previous work using invasive intracranial recordings and non-invasive scalp electroencephalography (EEG) has shown that correlations between beta phase and broadband gamma amplitude (i.e., phase-amplitude coupling) are elevated in PD, perhaps a reflection of this synchrony. Recently, it has also been shown, in invasive human recordings, that nonsinusoidal features of beta oscillation shape also characterize PD. Here we show that these features of beta waveform shape also distinguish PD patients on and off medication using non-invasive recordings in a dataset of 15 PD patients with resting scalp EEG. Specifically, beta oscillations over sensorimotor electrodes in PD patients off medication had greater sharpness asymmetry and steepness asymmetry than on medication (sign rank, p=0.006, p=0.003 respectively). We also showed that beta oscillations over sensorimotor cortex most often had a canonical shape and that using this prototypical shape as an inclusion criterion increased the effect size of our findings. Together our findings suggest that novel ways of measuring beta synchrony that incorporate waveform shape could improve detection of PD pathophysiology in non-invasive recordings.

Analyses of conditions for generating beta oscillations in the Cortex–Subthalamic Nucleus–Globus Pallidus model

2020 ◽  
Vol 34 (13) ◽  
pp. 2050134 ◽  
Author(s):  
Jing-Yi Zhao ◽  
Quan-Sheng Liu ◽  
Yuan-Hong Bi ◽  
Zhuo-Qin Yang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Globus Pallidus ◽  
Subthalamic Nucleus ◽  
Stability Boundary ◽  
Inhibitory Neurons ◽  
Beta Oscillations ◽  
Connection Weight ◽  
The Stability ◽  
Beta Oscillation

Analyzing the conditions for generating beta oscillation in basal ganglia plays a key role in understanding the mechanism of Parkinson’s disease (PD). In this paper, we consider a Cortex–STN–GPe model, which consists of the external segment of globus pallidus (GPe), subthalamic nucleus (STN) and cortex including excitatory and inhibitory neurons. We obtain the stability boundary conditions for the model through theoretical analyses, and discuss the influence of two inputs to cortex and GPe on oscillations by numerical simulation. Our results reveal that the model can oscillate for large connection weight between STN and GPe, much larger input to the cortex, and most input values to the GPe. Furthermore, the effects of parameters in the cortical circuit on the amplitude and frequency of the beta oscillation are analyzed. We show that larger delay and larger firing rate of excitatory and inhibitory neurons in the cortex make the model oscillate easily. We hope that our results will be helpful for further understanding the mechanisms of beta oscillations in the treatment of Parkinson’s disease and may apply to some studies of neural oscillations.

Evaluation of Efferent Auditory System and Hearing Quality in Parkinson's Disease: Is the Difficulty in Speech Understanding in Complex Listening Conditions Related to Neural Degeneration or Aging?

2020 ◽  
pp. 1-9
Author(s):  
Nuriye Yıldırım Gökay ◽  
Bülent Gündüz ◽  
Fatih Söke ◽  
Recep Karamert
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Auditory System ◽  
Otoacoustic Emissions ◽  
Pure Tone ◽  
Pure Tone Audiometry ◽  
Auditory Pathway ◽  
Normal Hearing ◽  
System Function ◽  
Distortion Product

Purpose The effects of neurological diseases on the auditory system have been a notable issue for investigators because the auditory pathway is closely associated with neural systems. The purposes of this study are to evaluate the efferent auditory system function and hearing quality in Parkinson's disease (PD) and to compare the findings with age-matched individuals without PD to present a perspective on aging. Method The study included 35 individuals with PD (mean age of 48.50 ± 8.00 years) and 35 normal-hearing peers (mean age of 49 ± 10 years). The following tests were administered for all participants: the first section of the Speech, Spatial and Qualities of Hearing Scale; pure-tone audiometry, speech audiometry, tympanometry, and acoustic reflexes; and distortion product otoacoustic emissions (DPOAEs) and contralateral suppression of DPOAEs. SPSS Version 25 was used for statistical analyses, and values of p < .05 were considered statistically significant. Results There were no statistically significant differences in the pure-tone audiometry thresholds and DPOAE responses between the individuals with PD and their normal-hearing peers ( p = .732). However, statistically significant differences were found between the groups in suppression levels of DPOAEs and hearing quality ( p < .05). In addition, a statistically significant and positive correlation was found between the amount of suppression at some frequencies and the Speech, Spatial and Qualities of Hearing Scale scores. Conclusions This study indicates that medial olivocochlear efferent system function and the hearing quality of individuals with PD were affected adversely due to the results of PD pathophysiology on the hearing system. For optimal intervention and follow-up, tasks related to hearing quality in daily life can also be added to therapies for PD.

Accessible Internet Training for People With Aphasia and Parkinson's Disease

2004 ◽  
Vol 9 (2) ◽  
pp. 10-13
Author(s):  
Linda Worrall ◽  
Jennifer Egan ◽  
Dorothea Oxenham ◽  
Felicity Stewart
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease

Voice Treatment for Individuals With Parkinson's Disease

2007 ◽  
Vol 12 (1) ◽  
pp. 2-11
Author(s):  
Lorraine Ramig ◽  
Cynthia Fox
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Voice Treatment
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